Abstract
Epidemiological investigations of the past 15 to 20 years leave little doubt that tobacco smoke is the most important single factor in the etiology of lung cancer. Nevertheless, many questions concerning the pathogenesis of this neoplastic disease — the role of predisposing host and environmental factors and the possibility of synergistic or potentiating effects from combinations of various biological, chemical, and physical agents — are still unanswered (Roe and Walters, 1965; Saffiotti, 1969). Some evidence for the interaction of etiological factors has been obtained in humans exposed to radon daughters and cigarette smoke (Saccomanno et al., 1971) and to asbestos and cigarette smoke (Selikoff et al., 1968).
Research jointly sponsored by the National Cancer Institute, and by the Atomic Energy Commission under contract with the Union Carbide Corporation.
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Nettesheim, P., Schreiber, H., Creasia, D.A., Richter, C.B. (1973). Respiratory Infections and the Pathogenesis of Lung Cancer. In: Grundmann, E. (eds) Special Topics in Carcinogenesis. Recent Results in Cancer Research, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80786-2_21
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