Carcinogen-induced Cellular Thesaurismoses and Neoplastic Cell Transformation

  • P. Bannasch
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 44)


It has been known for a long time from human pathology that many tumors contain cells which store polysaccharides or lipids. So far such pathological storage phenomena have been interpreted as a consequence of the neoplastic cell transformation and to be related to the general disturbance of tumor cell metabolism. Experimental investigations of the genesis of epithelial liver and kidney tumors have shown, however, that cellular thesaurismoses are mainly characteristic of the preneoplastic phase (Bannasch et al. 1964–1972). In the development of certain tumors they seem to be an inevitable step, indicating a basic alteration of cell metabolism. During cellular transformation there is usually a gradual reduction in the amount of the stored substances. Therefore, thesaurismoses in tumors can be considered as relicts of the preneoplastic phase. Four examples will be used to illustrate this concept.


Glycogen Storage Kidney Tumor Storage Cell Acid Mucopolysaccharide Bile Duct Epithelium 
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  1. Aleu, F. P., Terry, R. D., Zellweger, H.: J. Neuropath. exp. Neurol. 24, 304 (1965).PubMedCrossRefGoogle Scholar
  2. Apitz, K.: Virchows Arch. path. Anat. 311, 360 (1944).Google Scholar
  3. Bannasch, P.: Verh. dtsch. Ges. Path. 51, 343 (1967).Google Scholar
  4. Bannasch, P.: Recent Results in Cancer Research, Vol. 19. Berlin-Heidelberg-New York: Springer 1968.Google Scholar
  5. Bannasch, P., Klinge, O.: Virchows Arch. Abt. A path. Anat. 352, 157 (1971).CrossRefGoogle Scholar
  6. Bannasch, P., Müller, H.-A.: Arzneimittel-Forsch. 14, 805 (1964).Google Scholar
  7. Bannasch, P., Papenburg, J., Ross, W.: Z. Krebsforsch. 77, 108 (1972).CrossRefGoogle Scholar
  8. Bannasch, P., Reiss, W.: Naturwissenschaften 57, 46 (1970).PubMedCrossRefGoogle Scholar
  9. Bannasch, P., Reiss, W.: Z. Krebsforsch. 76, 193 (1971).CrossRefGoogle Scholar
  10. Bannasch, P., Schacht, U.: Virchows Arch. Abt. B Zellpath. 1, 95 (1968).Google Scholar
  11. Bannasch, P., Schacht, U.: Verh. dtsch. Ges. Path. 54, 464 (1970).Google Scholar
  12. Bannasch, P., Schacht, U., Weidner, R., Storch, E.: Verh. dtsch. path. Ges. 55,665 (1971).Google Scholar
  13. Epstein, Sh., Ito, N., Merkow, L., Farber, E.: Cancer Res. 27, 1702 (1967).PubMedGoogle Scholar
  14. Farber, E.: Advanc. Cancer Res. 7, 383 (1963).CrossRefGoogle Scholar
  15. Forget, A., Daoust, R.: Int. J. Cancer 5, 404 (1970).PubMedCrossRefGoogle Scholar
  16. Friedrich-Freksa, H., Gössner W., Börner, P.: Z. Krebsforsch. 72, 226 (1969).PubMedCrossRefGoogle Scholar
  17. Hard, G. C., Butler, W. H.: Cancer Res. 30, 2796 (1970).PubMedGoogle Scholar
  18. Hard, G. C., Butler, W. H.: Cancer Res. 31, 1496 (1971).PubMedGoogle Scholar
  19. Hobik, H. P., Grundmann, E.: Beitr. path. Anat. 127, 25 (1962).Google Scholar
  20. Hruban, Z., Morris, H. P., Mochizuki, Y., Meranze, D. R., Slesers, A.: Cancer Res. 31, 752 (1971).PubMedGoogle Scholar
  21. Ito, N., Johuo, I., Marugami, M., Konishi, Y., Hiasa, Y.: Gann 57, 595 (1966).PubMedGoogle Scholar
  22. Newberne, P. M., Wogan, G. N.: Cancer Res. 28, 770 (1968).PubMedGoogle Scholar
  23. Oehlert, W., Hartje, J.: Beitr. path. Anat. 128, 376 (1963).Google Scholar
  24. Porter, K. R., Bruni, C.: Cancer Res. 19, 997 (1959).PubMedGoogle Scholar
  25. Resibois, A., Tondeur, M., Mockel, S., Dustin, P.: Int. Rev. exp. Path. 9, 93 (1970).PubMedGoogle Scholar
  26. Reuber, M. D.: Gann Monograph 1, 43 (1966).Google Scholar
  27. Romen, W., Bannasch, P.: Virchows Arch. Abt. B. Zellpath. 10, 51 (1972).Google Scholar
  28. Schauer, A., Kunze, E.: Z. Krebsforsch. 70, 252 (1968).PubMedCrossRefGoogle Scholar
  29. Spycher, M. A., Gitzelmann, R.: Virchows Arch. Abt. B Zellpath. 8, 133 (1971).Google Scholar
  30. Suschke, J., Kunze, D.: Dtsch. med. Wschr. 96, 1941 (1971).PubMedCrossRefGoogle Scholar
  31. Weber, G.: Naturwissenschaften 55, 418 (1968).PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin · Heidelberg 1973

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  • P. Bannasch

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