Abstract
During the last two decades we have induced a large number of hepatomas and other types of tumors in inbred strains of rats at sites distant from the site of administration. The chemical carcinogens used have been incorporated at different dosage levels into adequate diets of natural food stuffs. Many of the primary hepatomas have been transplanted to new hosts of the strain of origin. Most, but not all, of these primary tumors grew in the new hosts. The tumors that grew have been maintained by serial transfer. These transplantable tumors are characterized by different rates of growth as measured by time between transfers. The size of the tumors at time of transfer is also highly correlated with growth rate.
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Morris, H.P., Meranze, D.R. (1973). Induction and Some Characteristics of “Minimal Deviation” and Other Transplantable Rat Hepatomas. In: Grundmann, E. (eds) Special Topics in Carcinogenesis. Recent Results in Cancer Research, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80786-2_17
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DOI: https://doi.org/10.1007/978-3-642-80786-2_17
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