Abstract
As a rule, acute leukemias are diagnosed and classified on the basis of Wright or Giemsa-stained blood and bone marrow smears. When a good marrow sample is obtained, histologic study of the tissue sections only rarely contributes to the diagnosis or classification. There are certain circumstances, however, under which histologic study of tissue sections may be essential to the diagnosis of acute leukemia. This is usually the case in the aleukemic patient when the marrow smear is poor in cells and some of these cells appear immature without being readily classifiable, or when a biopsy from an extramedullary lesion precedes a bone marrow study or is taken at a time when clear-cut leukemic changes in the bone marrow are not evident.
Supported, in part, by Grant No. CA-05838, from the National Cancer Institute, National Institutes of Health.
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References
Forkner, C. E.: Clinical and pathologic differentiation of the acute leukemias. With special reference to acute monocytic leukemia. Arch, intern. Med. 53, 1 (1934).
Leder, L. D.: Der Nachweis der Naphthol-AS-D-Chloracetat-Esterase und seine Bedeutung für die histologische Diagnostik. Verh. dtsch. path. Ges. 48, 317 (1964).
Mathé, G., Pouillart, P., Sterescu, M., Amiel, J. L., Schwarzenberg, L., Schneider, M., Hayat, M., De Vassal, F., Jasmin, C, Lafleur, M.: Subdivision of classical varieties of acute leukemia. Correlation with prognosis and cure expectancy. Europ. J. clin. biol. Res. 16, 554 (1971).
Rappaport, H.: Tumors of the hematopoietic system, p. 22. Washington, D. C., 1966, Armed Forces Institute of Pathology.
Rowley, J., Blaisdell, R. K., Jacobson, L. O.: Chromosome studies in preleukemia. Blood 27, 782 (1966)
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© 1973 Springer-Verlag Berlin · Heidelberg
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Rappaport, H. (1973). Histologic Criteria for Diagnosis and Classification of Acute Leukemias. In: Mathé, G., Pouillart, P., Schwarzenberg, L. (eds) Nomenclature, Methodology and Results of Clinical Trials in Acute Leukemias. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80776-3_7
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DOI: https://doi.org/10.1007/978-3-642-80776-3_7
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