A New Agent Active in the Treatment of Acute Myeloblastic Leukemia 22 050 RP

  • Cl. Jacquillat
  • M. Weil
  • M-F. Gemon
  • V. Izrael
  • M. Boiron
  • J. Bernard
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 43)

Abstract

This report concerns our preliminary clinical experience in 44 cases of acute myeloblastic leukemia with 22 050 RP (Fig. 1), the benzoyl-hydrazone chlorhydrate of daunorubicin (DNR). Among the semi-synthetic derivatives of DNR, 22 050 RP in L 1210 leukemia has a better therapeutic index than DNR (10 to 15 for 22 050 RP, 5 to 10 for DNR). Moreover, it is 50% less toxic than DNR and 75% less toxic than adriamycin [3].

Keywords

Toxicity Leukemia Diarrhea Purine Cytosine 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1973

Authors and Affiliations

  • Cl. Jacquillat
    • 1
  • M. Weil
    • 1
  • M-F. Gemon
    • 1
  • V. Izrael
    • 1
  • M. Boiron
    • 1
  • J. Bernard
    • 1
  1. 1.Hôpital Saint-LouisParisFrance

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