Abstract
Three related questions which have been discussed at this meeting fall within the fields of epidemiology and medical statistics. These questions are:
-
1.
Why does the “same” protocol produce different results at different centres?
-
2.
How should the results of clinical trials be presented (published)?
-
3.
What statistical methods should be used in the analysis of trial results?
It has always appeared to me that to make one’s point in discussing such questions a certain amount of exaggeration is desirable. I will follow this rule.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adelstein, A. M., Donovan, J. W.: Malignant disease in children whose mothers suffered chickenpox, mumps or rubella in pregnancy. Brit. med. J. 4, 629 (1972).
Bithell, J. F., Draper, G. J., Gorbach, P. D.: The association between malignant disease in children and maternal virus infections. Brit. med. J. 1, 706 (1972).
Cox, D. R.: Regression models and life tables. J. roy. statist. Soc. B 34, 187 (1972).
Fedrick, J., Alberman, E. D.: Reported influenza in pregnancy and subsequent cancer in the child. Brit. med. J. 2, 485 (1972).
Mantel, N.: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother. Rep. 50, 163 (1966).
Medical Research Council: Treatment of acute lymphoblastic leukaemia. Brit. med. J. 4, 189 (1971).
Medical Research Council: 1st MRC myelomatosis trial. I. Analysis of presenting features of prognostic importance. Brit. J. Haemat. 24, 123 (1972).
Peto, R., Peto, J.: Asymptotically efficient rank invariant test procedures. J. roy. statist. Soc. A 135, 185 (1972).
Peto, R., Pike, M. C.: Leukaemia trials. In: Medical surveys and clinical trials. 3rd Edition. Edited by S. C. Truelove. TO be published by Oxford University Press (1973).
Stewart, A., Barber, R.: The epidemiological importance of childhood cancers. Brit. med. Bull. 27, 64 (1971).
Walters, T. R., Bushore, M., Simone, J.: Poor prognosis in negro children with acute lymphocytic leukaemia. Cancer (Philad.) 29, 210 (1972).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1973 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Pike, M.C. (1973). The Analysis of Clinical Trials in Leukaemia. In: Mathé, G., Pouillart, P., Schwarzenberg, L. (eds) Nomenclature, Methodology and Results of Clinical Trials in Acute Leukemias. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80776-3_22
Download citation
DOI: https://doi.org/10.1007/978-3-642-80776-3_22
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80778-7
Online ISBN: 978-3-642-80776-3
eBook Packages: Springer Book Archive