Abstract
The availability of a colony-forming culture assay that detects early progenitors of granulopoiesis (colony forming units in culture; CFU-C) in human bone marrow cells [1, 2, 4, 5, 8, 9, 10] makes it possible to study cellular events in leukemia. Although the CFU-C culture method does not assay directly for the pluripotent myeloid stem cell, there is ample evidence that cells giving rise to colonies in culture are progeny of the pluripotent stem cell and may provide information about early cellular events (for review, see [7]). Marrow suspensions from adult patients with untreated acute myeloblastic leukemia were examined. The results indicate that there are at least several subtypes; this supports the view that the disease we call acute myeloblastic leukemia (AML) is mechanistically heterogeneous.
Supported by research grants from the Ontario Cancer Treatment and Research Foundation and Medical Research Council of Canada
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Cowan, D.H., Messner, H.A., Senn, J.S., McCulloch, E.A. (1973). The Heterogeneity of Cell Culture Findings in Patients with Acute Myeloblastic Leukemia. In: Mathé, G., Pouillart, P., Schwarzenberg, L. (eds) Nomenclature, Methodology and Results of Clinical Trials in Acute Leukemias. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80776-3_15
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DOI: https://doi.org/10.1007/978-3-642-80776-3_15
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