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The Secretin Test

  • Maurice J. Zimmerman
  • David A. Dreiling
  • Henry D. Janowitz
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 34)

Abstract

Secretin and pancreozymin are two hormones extractable from the mucosa of the upper small intestine which cause the pancreas to secrete water and bicarbonate and enzymes respectively.

Keywords

Chronic Pancreatitis Pancreatic Juice Pancreatic Disease Pancreatic Secretion Pancreatic Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ågren, G., Lagerlöf, H.: The pancreatic secretion in man after intravenous administration of secretin. Acta med. scand. 90, 1–29 (1936).CrossRefGoogle Scholar
  2. Bank, S., Marks, I. N., Moshal, M. G., Efron, G., Silber, R.: The pancreatic function test method and normal values. S. Afr. med. J. 37, 1061–1066 (1963).PubMedGoogle Scholar
  3. Banwell, J. G., Northam, B. E., Cooke, W. T.: Secretory response of the human pancreas to continuous intravenous infusion of secretin. Gut 8, 50–57 (1967).PubMedCrossRefGoogle Scholar
  4. Baron, J. H., Perrier, C. V., Janowitz, H. D., Dreiling, D. A.: Maximum alkaline (bicarbonate) output of the dog pancreas. Amer. J. Physiol. 204, 251–256 (1963).PubMedGoogle Scholar
  5. Baxter, S. G.: Parallel concentration of enzymes in pancreatic secretion. Amer. J. dig. Dis. 2, 108–111 (1935).Google Scholar
  6. Bayliss, W. M., Starling, E. H.: The mechanism of pancreatic secretion. J. Physiol. (Lond.) 28, 325–353 (1902).Google Scholar
  7. Bodanszky, A., Ondetti, M. A., Mutt, V., Bodanszky, M.: Synthesis of secretin. IV. Secondary structure in a miniature protein. J. Amer. chem. Soc. 91, 944–949 (1969).CrossRefGoogle Scholar
  8. Burton, P., Evans, D. G., Harper, A. A., Howat, H. T., Oleesky, S., Scott, J. E., Varley, H.: A test of pancreatic function in man based on the analysis of duodenal contents after administration of secretin and pancreozymin. Gut 1, 111–124 (1960a).PubMedCrossRefGoogle Scholar
  9. Burton, P., Hammond, E. M., Harper, A. A., Howat, H. T., Scott, J. E., Varley, H.: Serum amylase and serum lipase levels in man after administration of secretin and pancreozymin. Gut 1, 125–139 (1960b).PubMedCrossRefGoogle Scholar
  10. Chiray, M., Salmon, A. R., Mercier, A.: Action de la sécrétine purifiée; sur la sécrétion externe du pancréas de l’homme. Bull. Soc. Méd. Hôp. Paris. 3 ser. 50, 1417–1426 (1926).Google Scholar
  11. Choi, H. J., Goldstein, P., Wirts, C. W., Menduke, H.: Normal duodenal trypsin values in response to secretin. Pancreozymin stimulation with preliminary data in patients with pancreatic disease. Gastroenterology 53, 397–402 (1967).PubMedGoogle Scholar
  12. Comfort, M. W., Osterberg, A. E.: Pancreatic secretion in man after stimulation with secretin and acetylbeta methylcholine chloride. A comparative study. Arch. intern. Med. 66, 688–706 (1940).CrossRefGoogle Scholar
  13. Debray, C., Tour, J. de la, Vaille, C., Roze, C., Souchard, M.: Contribution a l’étude de la sécrétion biliaire et pancréatique externe chez le Rat. J. Physiol. (Paris) 54, 459–499 (1962).Google Scholar
  14. Diamond, J. S., Siegel, S. A., Gall, M. B., Karlen, S.: The use of secretin as a clinical test of pancreatic function. Amer. J. dig. Dis. 6, 366–372 (1939).CrossRefGoogle Scholar
  15. Diamond, J. S., Siegel, S. A.: The secretin test in the diagnosis of pancreatic diseases with a report of one hundred thirty tests. Amer. J. dig. Dis. 7, 435–442 (1940).CrossRefGoogle Scholar
  16. Dreiling, D. A.: The technique of the secretin test. Normal ranges. J. Mt Sinai Hosp. 21, 363–372 (1955).Google Scholar
  17. Dreiling, D. A.: Discussion. In Ciba Foundation Symposium: The Exocrine Pancreas (A.V.S. de Reuck, Ed.). Boston: Little, Brown 1962, pp. 253–254.Google Scholar
  18. Dreiling, D. A., Hollander, F.: Studies in pancreatic function, preliminary series of clinical studies with secretin test. Gastroenterology 11, 714–729 (1948).PubMedGoogle Scholar
  19. Dreiling, D. A., Hollander, F.: Studies in pancreatic function: II. A statistical study of pancreatic secretion following secretin in patients without pancreatic disease. Gastroenterology 15, 620–627 (1950).PubMedGoogle Scholar
  20. Dreiling, D. A., Nieburgs, H. E., Janowitz, H. D.: Combined secretin and cytology test in the diagnosis of pancreatic and biliary tract cancer. Med. Clin. N. Amer. 44, 801–815 (1960).PubMedGoogle Scholar
  21. Dreiling, D. A., Janowitz, H. D.: The secretion of electrolytes by the human pancreas. Gastroenterology 30, 382–390 (1956).PubMedGoogle Scholar
  22. Dreiling, D. A., Janowitz, H. D.: The laboratory diagnosis of pancreatic disease: Secretin test. Amer. J. Gastroent. 28, 268–275 (1957).PubMedGoogle Scholar
  23. Dreiling, D. A., Janowitz, H. D.: The secretion of electrolytes by the human pancreas. The effect of Diamox, ACTH, and disease. Amer. J. dig. Dis. 4, 137–144 (1959).CrossRefGoogle Scholar
  24. Dreiling, D. A., Janowitz, H. D.: The measurement of pancreatic secretory function. In Ciba Foundation Symposium: The Exocrine Pancreas (A.V.S. de Reuck, Ed.). Boston: Little, Brown 1962, pp. 225–252.Google Scholar
  25. Dreiling, D. A., Richman, A.: Evaluation of provocative blood enzyme tests employed in diagnosis of pancreatic disease. Arch. intern. Med. 94, 197–212 (1954).CrossRefGoogle Scholar
  26. Dreiling, D. A., Janowitz, H. D., Perrier, C. V.: Pancreatic Inflammatory Disease. A Physiologic Approach. New York: Harper & Row 1964.Google Scholar
  27. Duncan, P. R., Harper, A. A., Howat, H. T., Oleesky, S., Varley, H.: The effect of pancreozymin in human subjects. J. Physiol. (Lond.) 111, 63P (1950).Google Scholar
  28. Go, V. L. W., Hoffman, A. F., Summerskill, W. H. J.: Pancreozymin: Sites of secretion and effects on pancreatic enzyme output in man. J. clin. Invest. 48, 29a–30a (1969). (Abstract 94)Google Scholar
  29. Goldstein, F., Wirts, C. W., Cozzolino, H. J., Menduke, H.: Secretin tests of pancreatic and biliary tract disease. Arch. intern. Med. 114, 124–131 (1964).PubMedCrossRefGoogle Scholar
  30. Greenlee, H. B., Longhi, E H., Guerrero, J. D., Nelson, T. S., El-Bedri, A. L., Dragstedt, L. R.: Inhibitory effect of pancreatic secretin on gastric secretion. Amer. J. Physiol. 190, 396–402 (1957).PubMedGoogle Scholar
  31. Hanscom, D. H., Littman,A.: Dose-response relationships to pancreozymin in normal subjects and patients with chronic pancreatitis. Gastroenterology 45, 209–214 (1963).PubMedGoogle Scholar
  32. Hansky, J., Tiscornia, O. M., Dreiling, D. A., Janowitz, H. D.: Maximal secretory capacity of the canine pancreas in response to pancreozymin and secretin. Amer. J. Physiol. 206, 351–356 (1964).PubMedGoogle Scholar
  33. Grossman, M. I., Stability of secretin. Gastroenterology 57, 767 (1969).PubMedGoogle Scholar
  34. Harper, A. A., Raper, H. S.: Pancreozymin, a stimulant of the secretion of pancreatic enzymes in extracts of the small intestine. J. Physiol. (Lond.) 102, 115–125 (1943).Google Scholar
  35. Hartley, R. C., Gambill, E. E., Summerskill, W. H. J.: Pancreatic volume and bicarbonate output with augmented doses of secretin. Gastroenterology 48, 312–317 (1965).PubMedGoogle Scholar
  36. Howat, H. T.: Editorial. Usefulness of gastrointestinal hormones in diagnosis. Gastroenterology 42, 72–76 (1962).PubMedGoogle Scholar
  37. Howat, H. T.: Discussion. In Ciba Foundation Symposium: The Exocrine Pancreas (A.Y.S. de Reuck, Ed.). Boston: Little, Brown 1962, p. 253.Google Scholar
  38. Howat, H. T.: Evocative serum enzyme tests. In Pathogenese, Diagnostik, Klinik und Therapie der Erkrankungen des Exokreinen Pankreas (Henning, N., Heinkel, K., Schön, H., Eds.). Europäisches Pankreas-Symposion, 24. 5. bis 26. 5. 1963 in Erlangen. Stuttgart: F. K. Schattauer 1964, p. 163.Google Scholar
  39. Isenberg, J. I., Grossman, M. I.: Comparison of subcutaneous and intravenous secretin in man. Gastroenterology 56, 88–91 (1969).PubMedGoogle Scholar
  40. Janowitz, H. D., Dreiling, D. A.: The pancreatic secretion of fluid and electrolytes. In Ciba Foundation Symposium: The Exocrine Pancreas (A.V.S. de Reuck, Ed.). Boston: Little, Brown 1962, pp. 115–133.Google Scholar
  41. Janowitz, H. D.: Pancreatic secretion of fluid and electrolytes. In Handbook of Physiology Section 6: Alimentary Canal. Vol. II, Secretion (C. F. Code, Ed.). Washington, D. C.: American Physiological Society 1967, pp. 925–933.Google Scholar
  42. Johnston, C. G., Ball, E. G.: Variations in inorganic constituents of the pancreatic juice during constant drainage of the pancreatic ducts. J. biol. Chem. 86, 643–653 (1930).Google Scholar
  43. Jorpes, J. E.: The isolation and chemistry of secretin and cholecystokinin. Gastroenterology 55, 157–164 (1968).PubMedGoogle Scholar
  44. Jorpes, J. E., Mutt, V.: On the biological activity and amino acid composition of secretin. Acta chem. scand. 15, 1790–1791 (1961).CrossRefGoogle Scholar
  45. Jorpes, J. E., Mutt, V.: The gastrointestinal hormones secretin and cholecystokinin. Ciba Foundation Symposium on The exocrine pancreas. London: Churchill Ltd. 1962, pp. 150–164.Google Scholar
  46. Jorpes, J. E., Mutt, V., Magnusson, S., Steele, B. B.: Amino acid composition and N-terminal amino acid sequence of porcine secretin. Biochem. biophys. Res. Commun. 9, 275–279 (1962).CrossRefGoogle Scholar
  47. Kay, A. W.: Effect of large doses of histamine on gastric secretion of HCl; an augmented histamine test. Brit. med. J. 1953II, 77–80.CrossRefGoogle Scholar
  48. Konturek, S. J.: Comparison of pancreatic responses to natural and synthetic secretins in conscious cats. Amer. J. dig. Dis. 14, 557–565 (1969).PubMedCrossRefGoogle Scholar
  49. Lagerlöf, H. O.: Pancreatic secretion: Pathophysiology. In Handbook of Physiology Section 6: Alimentary Canal. Vol. II, Secretion (C. F. Code, Ed.). Washington, D.C.: American Physiological Society 1967, pp. 1027–1042.Google Scholar
  50. Lagerlöf, H. O.: Pancreatic function and pancreatic disease studied by means of secretin. Acta med. scand. Suppl. 128, 1–289 (1942).Google Scholar
  51. Lagerlöf, H. O., Schütz, H. B., Holmer, S.: A secretin test with high doses of secretin and correction for incomplete recovery of duodenal juice. Gastroenterology 52, 67–77 (1967).PubMedGoogle Scholar
  52. Lake, M.: Diagnostic value of secretin test, including report of 19 operated or autopsied cases with anatomical studies of pancreas. Amer. J. Med. 3, 18–30 (1947).PubMedCrossRefGoogle Scholar
  53. Lemon, H. M., Byenes, W. W.: Cancer of the biliary tract and pancreas: Diagnosis from cytology of duodenal aspiration. J. Amer. med. Ass. 141, 254–257 (1949).CrossRefGoogle Scholar
  54. Lim, R. K. S., Matheson, A. R., Schlapp, W.: An improved method for investigating the secretory function of the stomach and duodenum in the human subject. Quart. J. exp. Physiol. 13, 333–345 (1923).Google Scholar
  55. McNeer, G., Ewing, J. H.: Exfoliated pancreatic cancer cells in duodenal drainage: A case report. Cancer 2, 643–645 (1949).PubMedCrossRefGoogle Scholar
  56. Marks, I. N., Tompsett, S. L.: The diagnosis of pancreatic disease with special reference to a test of pancreatic secretion utilizing both secretin and pancreozymin stimulation. Quart. J. Med. 27, 431–461 (1958).PubMedGoogle Scholar
  57. Mellanby, J.: The isolation of secretin — its chemical and physiological properties. J. Physiol. (Lond.) 66, 1–18 (1928).Google Scholar
  58. Mutt, V., Joepes, J. E.: Secretin, isolation and determination of structure. IUPAC Internat. Congress on Chemistry of Natural Products, Stockholm, June 26–July 2, 1966. Section 2C–I. p. 119.Google Scholar
  59. Mutt, V., Joepes, J. E.: Isolation of aspartyl-phenylalanine amide from cholecystokinin-pancreozymin. Biochem. biophys. Res. Com. 26, 392–397 (1967).PubMedCrossRefGoogle Scholar
  60. Mutt, V., Joepes, J. E.: Secretin, Cholecystokinin. Communicated at the International Symposium on the “Pharmacology of Hormonal Polypeptides and Proteins” at the University of Milan, Sept. 14–16, 1967, Plenum Press 1968a, pp. 569–580.Google Scholar
  61. Mutt, V., Joepes, J. E.: Structure of porcine cholecystokinin-pancreozymin. 1. Cleavage with thrombin and with trypsin. Europ. J. Biochem. 6, 156–162 (1968c).PubMedCrossRefGoogle Scholar
  62. Mutt, V., Joepes, J. E.: Chemistry and physiology of cholecystokinin-pancreozymin. Proc. Internat. Un. Physiol. Sciences Vol. VI, 14 Internat. Congr. Washington 1968b, p. 193.Google Scholar
  63. Nieburgs, H. E., Dreiling, D. A., Rubio, C., Reisman, H.: The morphology of cells in duodenal drainage smears: Histologic origin and pathologic significance. Ainer. J. dig. Dis. 7, 489–505 (1962).CrossRefGoogle Scholar
  64. Ondetti, M. A., Rubin, B., Engel, S. L., Pluščec, J., Sheehan, J. T.: Cholecystokinin-pancreozymin: Recent developments. Amer. J. dig. Dis. 15, 149–156 (1970).PubMedCrossRefGoogle Scholar
  65. Pascal, J. P., Sannou, N., Ribet, A.: Exploration of pancreatic exocrine function by continuous infusion of secretin. Amer. J. dig. Dis. 13, 213–221 (1968).PubMedCrossRefGoogle Scholar
  66. Perrier, C. V.: La sécrétion hydrobicarbonatée du pancréas. Clinique. Stimulation maximale. Acta Gastroent. Belg. 29, 163–172 (1966).Google Scholar
  67. Perrier, C. V., Dreiling, D. A., Janowitz, H. D.: A stop flow analysis of pancreatic secretion. The effect of transient occlusion on the electrolyte composition of pancreatic juice. Gastroenterology 46, 700–705 (1964).PubMedGoogle Scholar
  68. Petersen, H.: The effect of pure natural secretin on the bicarbonate secretion into the duodenum in man. Scand. J. Gastroent. 5, 105–111 (1970).PubMedGoogle Scholar
  69. Popper, H. L., Necheles, H.: A new test for pancreatic function: Experimental observations. Gastroenterology 1, 490–499 (1943).Google Scholar
  70. Preshaw, R M., Grossman, M. I.: Comparison of subcutaneous and intravenous administration of pancreatic stimulants. Amer. J. Physiol. 209, 803–810 (1965).PubMedGoogle Scholar
  71. Raskin, H. F., Wenger, J., Sklar, M., Pleticka, S., Yarema, W.: Diagnosis of cancer of the pancreas, biliary tract and duodenum by combined cytologic and secretory methods. I. Exfoliative cytology and a description of a rapid method of duodenal intubation. Gastroenterology 34, 996–1008 (1958).PubMedGoogle Scholar
  72. Rosenberg, I. R., Friedland, N., Janowitz, H. D., Dreiling, D. A.: The effect of age and sex upon human pancreatic secretion of fluid and bicarbonate. Gastroenterology 50, 191–194 (1966).Google Scholar
  73. Rubin, C. E., Massey, B. W., Kirsner, J. B., Palmer, W. L., Stonecypher, D. D.: The clinical value of gastrointestinal cytologic diagnosis. Gastroenterology 25, 119–138 (1953).PubMedGoogle Scholar
  74. Sarles, H.: Editor. Pancreatitis. Symposium, Marseilles, April 25 and 26, 1963. Basel: S. Karger 1965.Google Scholar
  75. Solomon, A. K.: Electrolyte secretion in the pancreas. Fed. Proc. 11, 722–731 (1952).PubMedGoogle Scholar
  76. Somogyi, M.: Diastatic activity of human blood. Arch. intern. Med. 51, 665–679 (1941).CrossRefGoogle Scholar
  77. Stening, G. F., Vagne, M., Grossman, M. I.: Relative potency of commercial secretins. Gastroenterology 55, 687–689 (1968).PubMedGoogle Scholar
  78. Sun, D. C. H.: The use of pancreozymin-secretin test in the diagnosis of pancreatitis and tumors of the pancreas. Gastroenterology 45, 203–208 (1963).PubMedGoogle Scholar
  79. Sun, D. C. H.: Normal values for pancreozymin-secretin test. Gastroenterology 44, 602–606 (1963).PubMedGoogle Scholar
  80. Sun, D. C. H., Shay, H.: Pancreozymin-secretin test. The combined study of serum enzymes and duodenal contents in the diagnosis of pancreatic disease. Gastroenterology 38, 570–581 (1960).PubMedGoogle Scholar
  81. Vagne, M., Grossman, M. I.: Comparison of intravenous and subcutaneous secretin in dogs. Gastroenterology 54, 907–912 (1968).PubMedGoogle Scholar
  82. Vagne, M., Stening, G. F., Brooks, F. P., Grossman, M. I.: Synthetic secretin: Comparison with natural secretin for potency and spectrum of physiological actions. Gastroenterology 55, 260–267 (1968).PubMedGoogle Scholar
  83. Wenger, J., Raskin, H. F.: The diagnosis of cancer of the pancreas, biliary tract and duodenum by combined cytologic and secretory methods. II. The secretin test. Gastroenterology 34, 1009–1017 (1958).PubMedGoogle Scholar
  84. Werner, B., Mutt, V.: The pancreatic response in man to the injection of highly purified secretin and of pancreozymin. Scand. J. Clin. Lab. Invest. 6, 228–236 (1954).PubMedCrossRefGoogle Scholar
  85. Wormsley, K. G.: Response to secretin in man. Gastroenterology 54, 197–209 (1968).PubMedGoogle Scholar
  86. Wormsley, K. G.: The response to infusion of a combination of secretin and pancreozymin in health and disease. Scand. J. Gastroent. 4, 623–632 (1969).PubMedGoogle Scholar
  87. Zimmerman, M. J., Dreiling, D. A., Rosenberg, I. R., Janowitz, H. D.: Secretion of calcium by the canine pancreas. Gastroenterology 52, 865–870 (1967).PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1973

Authors and Affiliations

  • Maurice J. Zimmerman
  • David A. Dreiling
  • Henry D. Janowitz

There are no affiliations available

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