Secretin and Cholecystokinin (CCK)

  • J. Erik Jorpes
  • Viktor Mutt
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 34)

Abstract

In the history of our knowledge about the pancreas and its function, two names are particularly outstanding: those of Claude Bernard and Ivan Pavlov. But even Bernard, working in the middle of the 19th century, had his forerunners. About two hundred years earlier, Wirsungius had demonstrated that the pancreas has an excretory duct, and is by no means only a cushion of flesh (παν = all, ϰϱεασ = flesh) on which the stomach rests. The Russian name for the pancreas, Π ∏∂ℳℯπ𝑦∂о͞ϰαя ℳℯπℯзá, means the gland under the stomach. In the 1660’s Regnier de Graaf had cannulated the duct with a goose quill, and ascribed some importance for digestion to the juice collected from it. He found the name pancreas “minime conveniens” because “panereatis substantia tota glandulo sa est”. In 1828 Leuret and Lassaigne in France made a fundamental discovery. Upon finding that acetic acid, introduced into the duodenum, led to the secretion of pancreatic juice and bile, with dilation of the orifices of the pancreatic and bile ducts in the duodenum, they came to the following conclusion: “Since a weak acid is able to elicit secretion to the duodenum and to dilate the secretory ducts from the liver and the pancreas, the acid chyme ought to have the same property. It is acidic and it is emptied into the intestine when the digestive juices are needed.”

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