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Lactose Synthetase: Structure and Function

  • Conference paper
Metabolic Interconversion of Enzymes

  • 25 Accesses

Abstract

In many respects, lactose is a unique disaccharide in living things. It is synthesized only in an adult, female mammal and has not been found as such in plants or lower animal forms. The ability of animals to synthesize lactose appears to be, therefore, a rather recent event in animal evolution and may have occurred some 200 million years ago as mammals evolved. Lactose synthesis is also a tissue specific reaction since it occurs only in the mammary gland, and then but for the short periods of lactation during adult life. Although it should be evident from these considerations that the synthesis of lactose must be strictly controlled, it is only recently that some insight has been obtained into its regulation. It is the purpose of this report to discuss recent developments in our knowledge of the regulation of lactose synthesis and to consider the properties of the components of the regulatory system.

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References

  1. BREW, K., VANAMAN, T.C., and HILL, R.L., Proc. Natl. Acad. Sci., U.S., 59, 491 (1967).

    Article  Google Scholar 

  2. BROADBECK, U., and EBNER, K.E., J. Biol. Chem., 241, 762 (1966).

    Google Scholar 

  3. McGUIRE, E.J., JOURDIAN, G.W., CARLSON, D.M., and ROSEMAN, S., J. Biol. Chem., 240, PC4113 (1965).

    Google Scholar 

  4. Unpublished observations. Fluid in the embryonic chicken brain is a rich source of the transferase.

    Google Scholar 

  5. KLEE, W.A., and KLEE, C.B., Biochem. Biophys. Research Comm., 39, 833 (1970).

    Article  CAS  Google Scholar 

  6. MORRISON, J.F., and EBNER, K.E., J. Biol. Chem., 246, 3977 (1971).

    CAS  Google Scholar 

  7. MORRISON, J.F., and EBNER, K.E., J. Biol. Chem., 246, 3985 (1971).

    CAS  Google Scholar 

  8. MORRISON, J.F., and EBNER, K.E., J. Biol. Chem., 246, 3992 (1971).

    CAS  Google Scholar 

  9. JUERGENS, E.G., STOCKDALE, T.G., TOPPER, Y.J., and ELIAS, J.J., Proc. Natl. Acad. Sci., U.S., 54, 629 (1965).

    Article  CAS  Google Scholar 

  10. BREW, K., VANAMAN, T.C., and HILL, R.L., J. Biol. Chem., 242, 3747 (1967).

    CAS  Google Scholar 

  11. HILL, R.L., BREW, K., VANAMAN, T.C., TRAYER, I.P., and MATTOCK, P., Brookhaven Symp. in Biology, 21, 139 (1968).

    CAS  Google Scholar 

  12. BREW, K., “Essays in Biochemistry” edited by P. M. Campbell and F. Dickens, 6, 91 (1970). Academic Press.

    Google Scholar 

  13. TURKINGTON, R.W., BREW, K., VANAMAN, T.C., and HILL, R.L., J. Biol. Chem., 243, 3382 (1968).

    CAS  Google Scholar 

  14. TURKINGTON, R.W., and HILL, R.L., Science, 163, 1458 (1969).

    Article  CAS  Google Scholar 

  15. BREW, K., and HILL, R.L., J. Biol. Chem., 245, 4559 (1970).

    CAS  Google Scholar 

  16. BREW, K., CASTELLINO, F.J., VANAMAN, T.C., and HILL, R.L., J. Biol. Chem., 245, 4570 (1970).

    CAS  Google Scholar 

  17. VANAMAN, T.C., BREW, K., and HILL, R.L., J. Biol. Chem., 245, 4583 (1970).

    CAS  Google Scholar 

  18. CANFIELD, R.E., KAMMERMAN, S., GOBEL, J.H., and MORGAN, T.J., Nature New Biology, 232, 16 (1971).

    CAS  Google Scholar 

  19. BREW, K., personal communication.

    Google Scholar 

  20. BROWNE, W.J., NORTH, A.C.T., PHILLIPS, D.C., BREW, K., VANAMAN, T.C., and HILL, R.L., J. Mol. Biol., 42, 65 (1969).

    Article  CAS  Google Scholar 

  21. ROBBINS, F.M., and HOLMES, L.G., Biochem. Biophys. Acta. 221, 234 (1970).

    CAS  Google Scholar 

  22. COWBURN, D.A., BRADBURY, E.M., CRANE-ROBINSON, C., and GRATZER, W.B., Europ. J. Biochem., 14, 93 (1970).

    Article  Google Scholar 

  23. KIRGBAUM, W.R., and KUGLER, F.R., Biochemistry, 9 1216 (1970).

    Article  Google Scholar 

  24. PESSEN, H., KUMOSINSKI, T.F., and TIMASHEFF, S.N., J. Agric. Food Chem., 19. 698 (1971) .

    Article  CAS  Google Scholar 

  25. ATASSI, M.Z., HABEEB, A.F.S.A., and RYDSTEDT, L., Biochem. Biophys. Acta. 200. 184 (1970).

    CAS  Google Scholar 

  26. ARNON, R., and MARON, E., J. Mol. Biol., 51, 703 (1970).

    Article  CAS  Google Scholar 

  27. CASTELLINO, F.J., and HILL, R.L., J. Biol. Chem., 245, 417 (1970).

    CAS  Google Scholar 

  28. CASTELLINO, F.J., and HILL, R.L., Fed. Proc., 28, 405 (1969).

    Google Scholar 

  29. BARMAN, T.E., J. Biol. Biol., 52, 391 (1970).

    Article  CAS  Google Scholar 

  30. LIN, T.Y., Biochemistry, 9, 984 (1970).

    Article  CAS  Google Scholar 

  31. DENTON, W.L., and EBNER, K.E., J. Biol. Chem. 246, 4053 (1971).

    CAS  Google Scholar 

  32. LYSTER, R.L.J., JENNESS, R., PHILLIPS, N.I., and SLOAN, R.E., Comp. Biochem. Physiol., 17, 987 (1966).

    Google Scholar 

  33. SCHACHTER, H., JABBAL, I., HUDGIN, R.-L., PINTERIC, L., McGUIRE, E.J., and ROSEMAN, S., J. Biol. Chem., 245, 1090 (1970).

    CAS  Google Scholar 

  34. BREW, K., Nature, 223, 671 (1969).

    Article  Google Scholar 

  35. RAYER, I.P., and HILL, R.L., J. Biol. Chem., 246, 6666 (1971).

    Google Scholar 

  36. NDREWS, P., Fed. Eur. Biochem. Soc. Lett., 9, 297 (1970).

    Article  Google Scholar 

  37. AXEN, R., PORATH, J., and ERNBACK, S., Nature, 214, 1302 (1967).

    Article  CAS  Google Scholar 

  38. SHAPER, J.H., HILL, R.L., and BARKER, R., Fed. Proc., 30, 1265 (1971).

    Google Scholar 

  39. BARKER, R., OLSEN, K.W., SHAPER, J.H., and HILL, R.L., unpublished observations.

    Google Scholar 

  40. SCHWARTZ, M.L., PIZZO, S.V., HILL, R.L., and McKEE, P.A., J. Biol. Chem., 246, 5851 (1971).

    CAS  Google Scholar 

  41. REYNOLDS, J.A., and TANFORD, C., Proc. Natl. Acad. Sci., U.S., 66, 1002 (1970).

    Article  CAS  Google Scholar 

  42. NATHENSON, S.G., SHIMADA, A., YAMANE, K., MURAMATSU, T., CULLEN, S., MANN, D.L., FAHEY, J.L., and GRAFF, R., Fed. Proc., 29, 2026 (1970).

    CAS  Google Scholar 

  43. CLELAND, W.W., Biochem. Biophys. Acta, 67, 104 (1963).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, USA

    Robert L. Hill, Robert Barker, Kenneth W. Olsen, Joel H. Shaper & Ian P. Trayer

Authors
  1. Robert L. Hill
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  2. Robert Barker
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  3. Kenneth W. Olsen
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  4. Joel H. Shaper
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  5. Ian P. Trayer
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Editor information

Editors and Affiliations

  1. Institut für Diabetesforschung, 8000, Kölner Platz 1, München 23, GFR

    O. Wieland

  2. Physiologisch-chemisches Institut, Universität Würzburg, 8700, Koellikerstrasse 2, Würzburg, GFR

    E. Helmreich

  3. Biochemisches Institut, Universität Freiburg, 7800, Hermann-Herder-Strasse 7, Freiburg i.Br., GFR

    H. Holzer

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© 1972 Springer-Verlag Berlin · Heidelberg

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Hill, R.L., Barker, R., Olsen, K.W., Shaper, J.H., Trayer, I.P. (1972). Lactose Synthetase: Structure and Function. In: Wieland, O., Helmreich, E., Holzer, H. (eds) Metabolic Interconversion of Enzymes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80698-8_23

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  • DOI: https://doi.org/10.1007/978-3-642-80698-8_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-05919-6

  • Online ISBN: 978-3-642-80698-8

  • eBook Packages: Springer Book Archive

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