Diphtheria Toxin-catalyzed Adenosine Diphosphoribosylation of Aminoacyl Transferase II from Rat Liver
Diphtheria toxin is a simple protein consisting of a single polypeptide chain of 62,000 daltons. It is lethal for certain species of laboratory animals such as guinea pigs and rabbits in doses as low as 0.1 μg per kg body weight. The biochemical basis for this extremely high toxicity has been the subject of intensive investigation in a number of laboratories but has not been clearly understood for many years.
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