Detection and Assessment of Case Clustering in Burkitt’s Lymphoma and Hodgkin’s Disease
Any joint consideration of Burkitt’s Lymphoma (BL) and Hodgkin’s Disease (HD) may, at first glance, seem unwarranted. HD was first described in 1832 and is of world-wide distribution; BL was first described only in the late 1950’s and its occurrence is geographically very restricted. BL occurs in children and has distinctive clinical features; HD occurs at all ages and its diagnosis depends on histological features which themselves may be the subject of debate. BL is a neoplasm of lymphocytes, while in HD the role of lymphocytes is uncertain and complex. Despite these differences the 2 neoplasms may be considered in parallel because of the increasing circumstantial evidence for viral aetiology in both. If they are caused by viruses they may show some of the epidemiological features of infectious diseases. Recognition of these features may not only help to identify the viruses responsible but is essential to understanding the diseases themselves. Case clustering is one of the features of infectious diseases, and it is this which is the subject of this paper.
KeywordsMalignant Lymphoma Clinical Onset Diagnostic Error Sickle Cell Trait Time Cluster
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