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Primary Carcinomas of the Liver in Hong Kong: Some Possible Aetiological Factors

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Current Problems in the Epidemiology of Cancer and Lymphomas

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 39))

Abstract

The incidence of primary liver-cell cancer differs greatly from one part of the world to another. On the basis of the incidence rates published by U.I.C.C. (Doll, Payne and Waterhouse, 1966), Hutt (1971) defined three main groups of territories. The first group includes areas in Africa south of the Sahara and in southeast Asia where a rate of 5 or more per 100,000 of the population per year for males was recorded. In the second group, which includes Japan and Denmark, incidence rates from 5 to 3.1 were listed. The third group of low-incidence areas includes northern India, Australia, the Americas and most of Europe for which rates of 3 or less were given. Although strictly comparable rates are not available for Hong Kong, BELA-MARIC (1969) worked out a minimum rate of 5.9 there. Primary carcinoma of the liver is also a common tumour in China generally (Chinese Medical Association, 1958). In Chinese in Singapore the incidence rate is 31 per 100,000 per year for males (Simons et al., 1971).

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References

  • ALPERT, M. E., DAVIDSON, C. S.: Mycotoxins: a possible cause of primary carcinoma of the liver. Amer. J. Med. 46, 325–329 (1969).

    Article  PubMed  CAS  Google Scholar 

  • ALPERT, M. E., HUTT, M. S. R., WOGAN, G. N., DAVIDSON, C. S.: Association between aflatoxin content of food and hepatoma frequency in Uganda. Cancer 28, 253–260 (1971).

    Article  PubMed  CAS  Google Scholar 

  • BELAMARIC, J.: Malignant tumours in Chinese. Int. J. Cancer 4, 560–573 (1969).

    Article  PubMed  CAS  Google Scholar 

  • BHAMARAPRAVATI, N., VIRRANUVATTI, V.: Liver diseases in Thailand: an analysis of liver biopsies. Amer. J. Gastroent. 45, 267–275 (1966).

    PubMed  CAS  Google Scholar 

  • BLUMBERG, B. S.: Polymorphisms of serum proteins and the development of isoprecipitins in transfused patients. Bull. Acad. Med. (N.Y.) 40, 377 (1964).

    CAS  Google Scholar 

  • BONNE, C.: Cancer and human races. Amer. J. Cancer 30, 435–454 (1937).

    Google Scholar 

  • BRAS, G., JELLIFFE, D. B., STUART, K. L.: Veno-occlusive disease of the liver with nonportal type of cirrhosis, occurring in Jamaica. Arch. Path. (Chicago) 57, 285–300 (1954).

    CAS  Google Scholar 

  • Chinese Medical Association: Society of Pathology and Departments of Pathology of 38 Medical

    Google Scholar 

  • Colleges and Hospitals: statistical analysis of 1,979 autopsies of malignant diesase. Chin. J. Path. 4, 174–181 (1958), (in Chinese).

    Google Scholar 

  • CHOU, S. T., GIBSON, J. B.: The histochemistry of biliary mucins and the changes caused by infestation with Clonorchis sinensis J. Path. 101, 185–197 (1970).

    Article  CAS  Google Scholar 

  • CHOU, S. T., GIBSON, J. B.: A comparative histochemical study of rat livers in alpha-naphthyl-isothiocyanate (ANIT) and DL-Ethionine intoxication. In press. DOLL, R., PAYNE, P., WATERHOUSE, J.: Cancer Incidence in Five Continents. U.I.C.C. publication.Berlin-Heidelberg-New York: Springer 1966. Fifth Pan-American Congress of Gastroenterology: La Habana, Cuba, January 20–27, 1956.

    Google Scholar 

  • Report of the Board for classification and nomenclature of cirrhosis of the liver. Gastroenterology 31, 213–216 (1956).

    Google Scholar 

  • FARBER, E.: Carcinoma of the liver in rats fed ethionine. Arch. Path. 62, 445–454 (1956).

    CAS  Google Scholar 

  • GIBSON, J. B., SUN, T.: Clonorchiasis. In: Pathology of Protozoal and Helminthic Diseases. Ed. R. A. MARCIAL-ROJAS. Baltimore: Williams and Wilkins 1970, pp. 546–566.

    Google Scholar 

  • GIBSON, J. B.: Parasites, liver disease and liver cancer. In: Liver Cancer. I.A.R.C. Scientific Publi-cations, No. 1. Lyon: International Agency for Research on Cancer 1971, pp. 42–50.

    Google Scholar 

  • GUPTA, D. N.: Nodular cirrhosis and metastasising tumours produced in the liver of rats by prolonged feeding with thioacetamide. J. Path. Bact. 72, 415–426 (1956).

    Article  CAS  Google Scholar 

  • HART, J., MODAN, B., SHANI, M.: Cholelithiasis in the aetiology of gall bladder neoplasms. Lancet 19711, 1151–1153.

    Google Scholar 

  • HULL, E. W., CARBONE, P. P., GITLIN, D., O’GARA, R. W., KELLY, M. G.: Alpha-foetoprotein in monkeys with hepatoma. J. nat. Cancer Inst. 42, 1035 (1969).

    PubMed  CAS  Google Scholar 

  • HUTT, M. S. R.: Epidemiology of human primary liver cancer. In: Liver Cancer. I.A.R.C. Scientific Publications, No. 1. Lyon: International Agency for Research on Cancer 1971, pp. 21–29.

    Google Scholar 

  • KENNAWAY, E. L.: Cancer of the liver in the negro in Africa and in America. Cancer Res. 4, 571–577 (1944).

    Google Scholar 

  • LIANG, P. C, TUNG, C.: Morphologic study and etiology of primary liver carcinoma and its in-cidence in China. Chin. med. J. 79, 336–347 (1959).

    PubMed  CAS  Google Scholar 

  • MA, LILY: Personal communication, 1971.

    Google Scholar 

  • MCGLASHAN, N. D., WALTERS, C. L., MCLEAN, A.E.M.: Nitrosamines in African spirits and oeso-phageal cancer. Lancet 1968II, 1017.

    Article  Google Scholar 

  • MAGEE, P. N.: Toxicity of nitrosamines: their possible human health hazard. Fd. Cosmet. Toxicol. 9, 207–218 (1970).

    Article  Google Scholar 

  • MIYAKE, M., SAITO, M., ENOMOTO, M., SHIKATA, T., ISHIKO, T., URAGUCHI, K., SAKAI, F., TAT-SUNO, T., TSUKIOKA, M., SAKAI, Y.: Toxic liver injuries and liver cirrhosis induced in mice and rats through long-term feeding with Penicillium Islandicum, Sopp growing rice. Acta path. jap. 10, 75–123 (1960).

    PubMed  CAS  Google Scholar 

  • NAFTALIN, J. M.: Interactions between environment and diet in the production of acute liver necrosis in the rat. J. Path. Bact. 63, 649–666 (1951).

    Article  PubMed  CAS  Google Scholar 

  • OPIE, E. L.: The pathogenesis of tumors of the liver produced by butter yellow. J. exp. Med. 80, 231–246 (1944).

    Article  PubMed  CAS  Google Scholar 

  • PEACOCK, P. R.: Carcinogenesis. In: Cancer; ed. R. W. RAVEN, Vol. I. London: Butterworth & Co. 1957, p. 65.

    Google Scholar 

  • PETROV, N., KROTKINA, N.: Experimentelles Gallenblasen-und Lebercarcinom. Z. Krebsforsch. 38, 249–263 (1933).

    Article  Google Scholar 

  • PRINCE, A. F.: Role of viruses in chronic liver disease in man an animals. In: Liver Cancer. I.A.R.C. Scientific Publications, No. 1. Lyon: International Agency for Research on Cancer 1971, pp. 51 to 57.

    Google Scholar 

  • SCHOENTAL, R.: Liver lesions in young rats suckled by mothers treated with the pyrrolidine (senecio) alkaloids, lasiocarpine and retrorsine. J. Path. Bact. 77, 485–496 (1959).

    Article  PubMed  CAS  Google Scholar 

  • SCHOENTAL, R., HEAD, M. A., PEACOCK, P. R.: Senecio alkaloids; primary liver tumours in rats as a result of treatment with (1) a mixture of alkaloids from S. Jacobea, lin.: (2) Retrorsine: (3) Isatidine. Brit. J. Cancer 8, 458–465 (1954).

    Article  PubMed  CAS  Google Scholar 

  • SCHOENTAL, R., HEAD, M. A.: Progression of liver lesions produced in rats by temporary treatment with pyrrolizidine (senecio) alkaloids and the effects of betaine and high casein diet. Brit. J. Cancer 11, 535–544 (1957).

    Article  PubMed  CAS  Google Scholar 

  • SCHOENTAL, R., MAGEE, P. N.: Chronic liver changes in rats after a single dose of lasiocarpine, a pyrrolizidine (senecio) alkaloid. J. Path. Bact. 74, 305–319 (1957).

    Article  CAS  Google Scholar 

  • SCHOENTAL, R., MAGEE, P. N.: Further observations on the subacute and chronic liver changes in rats after a single dose of various pyrrolizidine (senecio) alkaloids. J. Path. Bact, 78, 471–482 (1959).

    Article  PubMed  CAS  Google Scholar 

  • SHANK, R. C, WOGAN, G. N., GIBSON, J. B.: Dietary aflatoxins and human liver cancer. I. Toxigenic molds in foods and foodstuffs of tropical Southeast Asia. Fd. Cosmet. Toxicol., (in press).

    Google Scholar 

  • SHANK, R. C, WOGAN, G. N., GIBSON, J. B., NONDASUTA, A.: Dietary aflatoxins and human liver cancer. II. Aflatoxins in market foods and foodstuffs of Thailand and Hong Kong. Fd. Cosmet. Toxicol., (in press).

    Google Scholar 

  • SHANK, R. C, GORDON, J. E., WOGAN, G. N., NONDASUTA, A., Subhamani, B.: Dietary aflatoxins and human liver cancer. III. Field survey of rural Thai families for ingested aflatoxins. Fd. Cosmet. Toxicol., (in press).

    Google Scholar 

  • SHANK, R. C, GORDON, J.E., WOGAN, G. N., BHAMARAPRAVATI, N.: Dietary aflatoxins and human liver cancer. IV. Incidence of primary liver cancer in two municipal populations of Thailand. Fd. Cosmet. Toxicol., (in press).

    Google Scholar 

  • SHANK, R. C, GORDON, J. E., WOGAN, G. N., SIDDHICHAI, P., SUBHAMANI, B., BHAMARAPRAVATI, N.: Dietary aflatoxins and human liver cancer. V. Duration of primary liver cancer and prevalence of hepatomegaly in Thailand. Fd. Cosmet. Toxicol., (in press).

    Google Scholar 

  • SIMONS, M. J., YAP, E. H., YU, M., SEAH, C. S., CHEW, B. K., FUNG, W. P., TAM, A. Y. O., SHAMU-GARATNAM, K.: Australia antigen in Singapore Chinese patients with hepatocellular carcinoma. Lancet 19711, 1149–1151.

    Google Scholar 

  • SMITH, J. B., BLUMBERG, B. S.: Viral Hepatitis, Postnecrotic Cirrhosis and Hepatocellular Carcinoma. Lancet 1969 II, 953.

    Article  Google Scholar 

  • SUN, T., GIBSON, J. B.: Antigens of Clonorchis sinensis in experimental and human infections: an analysis by gel-diffusion technique. Amer. J. trop. Med. Hyg. 18, 241–252 (1968).

    Google Scholar 

  • SUN, T., GIBSON, J. B.: Metabolic products of adult Clonorchis sinensis: their composition and antigenic potential. J. Helminth. 43, 395–402 (1969).

    Article  PubMed  CAS  Google Scholar 

  • STEWART, M. J.: Precancerous lesions of the alimentary tract. Lancet 1931 II, 565–572, 617–622, 669–674.

    Article  Google Scholar 

  • VOGEL, C. L., ANTHONY, P. P., MODY, N., BARKER, L. F.: Hepatitis associated Antigen in Ugandan patients with hepatocellular carcinoma. Lancet 1970 II, 622–624.

    Google Scholar 

  • YEH, S.: Some geographic pathology aspects of common diseases in Taiwan. Part I and II. Int. Pathology 6, 81–85 (1965); 7, 24–28 (1965 and 1966).

    Google Scholar 

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Gibson, J.B., Chan, W.C. (1972). Primary Carcinomas of the Liver in Hong Kong: Some Possible Aetiological Factors. In: Grundmann, E., Tulinius, H. (eds) Current Problems in the Epidemiology of Cancer and Lymphomas. Recent Results in Cancer Research, vol 39. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80686-5_10

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  • DOI: https://doi.org/10.1007/978-3-642-80686-5_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80688-9

  • Online ISBN: 978-3-642-80686-5

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