Abstract
The incidence of primary liver-cell cancer differs greatly from one part of the world to another. On the basis of the incidence rates published by U.I.C.C. (Doll, Payne and Waterhouse, 1966), Hutt (1971) defined three main groups of territories. The first group includes areas in Africa south of the Sahara and in southeast Asia where a rate of 5 or more per 100,000 of the population per year for males was recorded. In the second group, which includes Japan and Denmark, incidence rates from 5 to 3.1 were listed. The third group of low-incidence areas includes northern India, Australia, the Americas and most of Europe for which rates of 3 or less were given. Although strictly comparable rates are not available for Hong Kong, BELA-MARIC (1969) worked out a minimum rate of 5.9 there. Primary carcinoma of the liver is also a common tumour in China generally (Chinese Medical Association, 1958). In Chinese in Singapore the incidence rate is 31 per 100,000 per year for males (Simons et al., 1971).
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References
ALPERT, M. E., DAVIDSON, C. S.: Mycotoxins: a possible cause of primary carcinoma of the liver. Amer. J. Med. 46, 325–329 (1969).
ALPERT, M. E., HUTT, M. S. R., WOGAN, G. N., DAVIDSON, C. S.: Association between aflatoxin content of food and hepatoma frequency in Uganda. Cancer 28, 253–260 (1971).
BELAMARIC, J.: Malignant tumours in Chinese. Int. J. Cancer 4, 560–573 (1969).
BHAMARAPRAVATI, N., VIRRANUVATTI, V.: Liver diseases in Thailand: an analysis of liver biopsies. Amer. J. Gastroent. 45, 267–275 (1966).
BLUMBERG, B. S.: Polymorphisms of serum proteins and the development of isoprecipitins in transfused patients. Bull. Acad. Med. (N.Y.) 40, 377 (1964).
BONNE, C.: Cancer and human races. Amer. J. Cancer 30, 435–454 (1937).
BRAS, G., JELLIFFE, D. B., STUART, K. L.: Veno-occlusive disease of the liver with nonportal type of cirrhosis, occurring in Jamaica. Arch. Path. (Chicago) 57, 285–300 (1954).
Chinese Medical Association: Society of Pathology and Departments of Pathology of 38 Medical
Colleges and Hospitals: statistical analysis of 1,979 autopsies of malignant diesase. Chin. J. Path. 4, 174–181 (1958), (in Chinese).
CHOU, S. T., GIBSON, J. B.: The histochemistry of biliary mucins and the changes caused by infestation with Clonorchis sinensis J. Path. 101, 185–197 (1970).
CHOU, S. T., GIBSON, J. B.: A comparative histochemical study of rat livers in alpha-naphthyl-isothiocyanate (ANIT) and DL-Ethionine intoxication. In press. DOLL, R., PAYNE, P., WATERHOUSE, J.: Cancer Incidence in Five Continents. U.I.C.C. publication.Berlin-Heidelberg-New York: Springer 1966. Fifth Pan-American Congress of Gastroenterology: La Habana, Cuba, January 20–27, 1956.
Report of the Board for classification and nomenclature of cirrhosis of the liver. Gastroenterology 31, 213–216 (1956).
FARBER, E.: Carcinoma of the liver in rats fed ethionine. Arch. Path. 62, 445–454 (1956).
GIBSON, J. B., SUN, T.: Clonorchiasis. In: Pathology of Protozoal and Helminthic Diseases. Ed. R. A. MARCIAL-ROJAS. Baltimore: Williams and Wilkins 1970, pp. 546–566.
GIBSON, J. B.: Parasites, liver disease and liver cancer. In: Liver Cancer. I.A.R.C. Scientific Publi-cations, No. 1. Lyon: International Agency for Research on Cancer 1971, pp. 42–50.
GUPTA, D. N.: Nodular cirrhosis and metastasising tumours produced in the liver of rats by prolonged feeding with thioacetamide. J. Path. Bact. 72, 415–426 (1956).
HART, J., MODAN, B., SHANI, M.: Cholelithiasis in the aetiology of gall bladder neoplasms. Lancet 19711, 1151–1153.
HULL, E. W., CARBONE, P. P., GITLIN, D., O’GARA, R. W., KELLY, M. G.: Alpha-foetoprotein in monkeys with hepatoma. J. nat. Cancer Inst. 42, 1035 (1969).
HUTT, M. S. R.: Epidemiology of human primary liver cancer. In: Liver Cancer. I.A.R.C. Scientific Publications, No. 1. Lyon: International Agency for Research on Cancer 1971, pp. 21–29.
KENNAWAY, E. L.: Cancer of the liver in the negro in Africa and in America. Cancer Res. 4, 571–577 (1944).
LIANG, P. C, TUNG, C.: Morphologic study and etiology of primary liver carcinoma and its in-cidence in China. Chin. med. J. 79, 336–347 (1959).
MA, LILY: Personal communication, 1971.
MCGLASHAN, N. D., WALTERS, C. L., MCLEAN, A.E.M.: Nitrosamines in African spirits and oeso-phageal cancer. Lancet 1968II, 1017.
MAGEE, P. N.: Toxicity of nitrosamines: their possible human health hazard. Fd. Cosmet. Toxicol. 9, 207–218 (1970).
MIYAKE, M., SAITO, M., ENOMOTO, M., SHIKATA, T., ISHIKO, T., URAGUCHI, K., SAKAI, F., TAT-SUNO, T., TSUKIOKA, M., SAKAI, Y.: Toxic liver injuries and liver cirrhosis induced in mice and rats through long-term feeding with Penicillium Islandicum, Sopp growing rice. Acta path. jap. 10, 75–123 (1960).
NAFTALIN, J. M.: Interactions between environment and diet in the production of acute liver necrosis in the rat. J. Path. Bact. 63, 649–666 (1951).
OPIE, E. L.: The pathogenesis of tumors of the liver produced by butter yellow. J. exp. Med. 80, 231–246 (1944).
PEACOCK, P. R.: Carcinogenesis. In: Cancer; ed. R. W. RAVEN, Vol. I. London: Butterworth & Co. 1957, p. 65.
PETROV, N., KROTKINA, N.: Experimentelles Gallenblasen-und Lebercarcinom. Z. Krebsforsch. 38, 249–263 (1933).
PRINCE, A. F.: Role of viruses in chronic liver disease in man an animals. In: Liver Cancer. I.A.R.C. Scientific Publications, No. 1. Lyon: International Agency for Research on Cancer 1971, pp. 51 to 57.
SCHOENTAL, R.: Liver lesions in young rats suckled by mothers treated with the pyrrolidine (senecio) alkaloids, lasiocarpine and retrorsine. J. Path. Bact. 77, 485–496 (1959).
SCHOENTAL, R., HEAD, M. A., PEACOCK, P. R.: Senecio alkaloids; primary liver tumours in rats as a result of treatment with (1) a mixture of alkaloids from S. Jacobea, lin.: (2) Retrorsine: (3) Isatidine. Brit. J. Cancer 8, 458–465 (1954).
SCHOENTAL, R., HEAD, M. A.: Progression of liver lesions produced in rats by temporary treatment with pyrrolizidine (senecio) alkaloids and the effects of betaine and high casein diet. Brit. J. Cancer 11, 535–544 (1957).
SCHOENTAL, R., MAGEE, P. N.: Chronic liver changes in rats after a single dose of lasiocarpine, a pyrrolizidine (senecio) alkaloid. J. Path. Bact. 74, 305–319 (1957).
SCHOENTAL, R., MAGEE, P. N.: Further observations on the subacute and chronic liver changes in rats after a single dose of various pyrrolizidine (senecio) alkaloids. J. Path. Bact, 78, 471–482 (1959).
SHANK, R. C, WOGAN, G. N., GIBSON, J. B.: Dietary aflatoxins and human liver cancer. I. Toxigenic molds in foods and foodstuffs of tropical Southeast Asia. Fd. Cosmet. Toxicol., (in press).
SHANK, R. C, WOGAN, G. N., GIBSON, J. B., NONDASUTA, A.: Dietary aflatoxins and human liver cancer. II. Aflatoxins in market foods and foodstuffs of Thailand and Hong Kong. Fd. Cosmet. Toxicol., (in press).
SHANK, R. C, GORDON, J. E., WOGAN, G. N., NONDASUTA, A., Subhamani, B.: Dietary aflatoxins and human liver cancer. III. Field survey of rural Thai families for ingested aflatoxins. Fd. Cosmet. Toxicol., (in press).
SHANK, R. C, GORDON, J.E., WOGAN, G. N., BHAMARAPRAVATI, N.: Dietary aflatoxins and human liver cancer. IV. Incidence of primary liver cancer in two municipal populations of Thailand. Fd. Cosmet. Toxicol., (in press).
SHANK, R. C, GORDON, J. E., WOGAN, G. N., SIDDHICHAI, P., SUBHAMANI, B., BHAMARAPRAVATI, N.: Dietary aflatoxins and human liver cancer. V. Duration of primary liver cancer and prevalence of hepatomegaly in Thailand. Fd. Cosmet. Toxicol., (in press).
SIMONS, M. J., YAP, E. H., YU, M., SEAH, C. S., CHEW, B. K., FUNG, W. P., TAM, A. Y. O., SHAMU-GARATNAM, K.: Australia antigen in Singapore Chinese patients with hepatocellular carcinoma. Lancet 19711, 1149–1151.
SMITH, J. B., BLUMBERG, B. S.: Viral Hepatitis, Postnecrotic Cirrhosis and Hepatocellular Carcinoma. Lancet 1969 II, 953.
SUN, T., GIBSON, J. B.: Antigens of Clonorchis sinensis in experimental and human infections: an analysis by gel-diffusion technique. Amer. J. trop. Med. Hyg. 18, 241–252 (1968).
SUN, T., GIBSON, J. B.: Metabolic products of adult Clonorchis sinensis: their composition and antigenic potential. J. Helminth. 43, 395–402 (1969).
STEWART, M. J.: Precancerous lesions of the alimentary tract. Lancet 1931 II, 565–572, 617–622, 669–674.
VOGEL, C. L., ANTHONY, P. P., MODY, N., BARKER, L. F.: Hepatitis associated Antigen in Ugandan patients with hepatocellular carcinoma. Lancet 1970 II, 622–624.
YEH, S.: Some geographic pathology aspects of common diseases in Taiwan. Part I and II. Int. Pathology 6, 81–85 (1965); 7, 24–28 (1965 and 1966).
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Gibson, J.B., Chan, W.C. (1972). Primary Carcinomas of the Liver in Hong Kong: Some Possible Aetiological Factors. In: Grundmann, E., Tulinius, H. (eds) Current Problems in the Epidemiology of Cancer and Lymphomas. Recent Results in Cancer Research, vol 39. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80686-5_10
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