Chromosome Aneuploidy in Human Malignancies: Solid Tumours
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Chromosome studies of malignant cell populations in “solid” tumours of man are more difficult than those of the free cells in effusions, due to technical difficulties and the scarcity of dividing cells in biopsy material. Before 1956 a few observations had been made concerning abnormal chromosome constitution and behaviour in tumours, but no comparative cytological analysis of groups of human malignancies had been carried out. In a report considered to be “the earliest karyological characterization of human neoplasms” (Hsu, 1961) the present author described chromosome behaviour in a hypo-diploid adeno-carcinoma. The chromosome number in this particular tumour showed a great variation, cells with 36, 32, 24 and 16 chromosomes being the most numerous. Synchronous division of groups of adjacent cells was frequent. Chromosomes and occasionally whole chromosome sets were found to fragment, as shown in Fig. 26.
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