Mitotic Anomalies in Tumours and Boveri’s Theory

  • Peo C. Koller
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 38)


The growth of cancerous tissue depends on cell multiplication, and the process by which cancer cells multiply had already drawn the attention of pathologists in the last century. Arnold (1879) was the first to describe cell division in human tumours, and cells which he saw containing several nuclei suggested to him that they were produced by “multiple” division of the nucleus. The term “chromosome” was only a year old when Klebs (1889) described aberrant mitosis in tumour tissue, and noted that in some cells the number of “chromosome bodies” was very large.


Daughter Nucleus Chromosome Constitution Ascites Tumour Cellular Heterogeneity Dicentric Chromosome 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1972

Authors and Affiliations

  • Peo C. Koller
    • 1
  1. 1.University of LondonUK

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