The increase in water permeability of the toad bladder produced by vasopressin is inhibited by PGE1 (Orloff, Handler and Bergström, 1965). Similar anti-vasopressin actions of PGE1 have been observed on the rabbit collecting tubule (Orloff and Grantham, 1967). Since these effects of vasopressin are known to be mediated by cyclic AMP, which is not inhibited by PGE1, it is likely that PGE1 acts by inhibiting adenyl cyclase.
KeywordsFree Water Clearance Toad Bladder Renal Prostaglandin Natriuretic Hormone Renal Cortical Slice
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