Prostaglandins pp 154-156 | Cite as

Urinary System

  • Eric William Horton
Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 7)


The increase in water permeability of the toad bladder produced by vasopressin is inhibited by PGE1 (Orloff, Handler and Bergström, 1965). Similar anti-vasopressin actions of PGE1 have been observed on the rabbit collecting tubule (Orloff and Grantham, 1967). Since these effects of vasopressin are known to be mediated by cyclic AMP, which is not inhibited by PGE1, it is likely that PGE1 acts by inhibiting adenyl cyclase.


Free Water Clearance Toad Bladder Renal Prostaglandin Natriuretic Hormone Renal Cortical Slice 
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  1. Herzog, J. P., Johnston, H. H., Lauler, D. P.: Effects of prostaglandins E1, E2 and A1 on renal hemodynamics, sodium and water excretion in the dog. Prostaglandin Symposium of the Worcester Foundation for Exp. Biol. Eds.: P. W. Ramwell and J. E. Shaw. New York: Inter-science 1968, pp. 147–161.Google Scholar
  2. Horton, E. W., Jones, R. L.: Prostaglandins A1, A2 and 19-hydroxy A1; their actions on smooth muscle and their inactivation on passage through the pulmonary and hepatic portal vascular beds. Brit. J. Pharmac. 37, 705–722 (1969).Google Scholar
  3. Lee, J. B.: Hypertension, natriuresis, and the renal prostaglandins (Editorial). Ann. intern. Med. 70, 1033–1038 (1969).PubMedGoogle Scholar
  4. Lee, J. B., Crowshaw, K., Takman, B. H., Attrep, K. A., Gougoutas, J. Z.: The identification of prostaglandins E2, F and A2 from rabbit kidney medulla. Biochem. J. 105, 1251–1260 (1967).PubMedGoogle Scholar
  5. Lee, J. B., Ferguson, J. F.: Prostaglandins and natriuresis: the effect of renal prostaglandins on PAH uptake by kidney cortex. Nature (Lond.) 222, 1185–1186 (1969).CrossRefGoogle Scholar
  6. McGiff, J. C., Terragno, N. A., Strand, J. C., Lee, J. B., Lonigro, A. J., Ng, K. K. F.: Selective passage of prostaglandins across the lung. Nature (Lond.) 223, 742–745 (1969).CrossRefGoogle Scholar
  7. Orloff, J., Grantham, J.: The effect of prostaglandin (PGE1) on the permeability response of rabbit collecting tubules to vasopressin. Nobel Symposium 2, Prostaglandins. Eds.: S. Bergström and B. Samuelsson. Stockholm: Almqvist and Wiksell 1967, pp. 143–146.Google Scholar
  8. Orloff, J., Handler, J. S., Bergström, S.: Effect of prostaglandin (PGE1) on the permeability response of the toad bladder to vasopressin, theophylline and adenosine 3′,5′-monophosphate. Nature (Lond.) 205, 397–398 (1965).CrossRefGoogle Scholar
  9. Vander, A. J.: Direct effects of prostaglandin on renal function and renin release in anesthetized dog. Amer. J. Physiol. 214, 218–221 (1968).PubMedGoogle Scholar

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© Springer-Verlag Berlin · Heidelberg 1972

Authors and Affiliations

  • Eric William Horton
    • 1
  1. 1.Department of PharmacologyUniversity of EdinburghEdinburghGreat Britain

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