The increase in water permeability of the toad bladder produced by vasopressin is inhibited by PGE1 (Orloff, Handler and Bergström, 1965). Similar anti-vasopressin actions of PGE1 have been observed on the rabbit collecting tubule (Orloff and Grantham, 1967). Since these effects of vasopressin are known to be mediated by cyclic AMP, which is not inhibited by PGE1, it is likely that PGE1 acts by inhibiting adenyl cyclase.
KeywordsPermeability Filtration Adenosine Prostaglandin PGE1
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- Herzog, J. P., Johnston, H. H., Lauler, D. P.: Effects of prostaglandins E1, E2 and A1 on renal hemodynamics, sodium and water excretion in the dog. Prostaglandin Symposium of the Worcester Foundation for Exp. Biol. Eds.: P. W. Ramwell and J. E. Shaw. New York: Inter-science 1968, pp. 147–161.Google Scholar
- Horton, E. W., Jones, R. L.: Prostaglandins A1, A2 and 19-hydroxy A1; their actions on smooth muscle and their inactivation on passage through the pulmonary and hepatic portal vascular beds. Brit. J. Pharmac. 37, 705–722 (1969).Google Scholar
- Orloff, J., Grantham, J.: The effect of prostaglandin (PGE1) on the permeability response of rabbit collecting tubules to vasopressin. Nobel Symposium 2, Prostaglandins. Eds.: S. Bergström and B. Samuelsson. Stockholm: Almqvist and Wiksell 1967, pp. 143–146.Google Scholar