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Brief Review of the Immunology of Insulin

  • Konrad Federlin
Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 6)

Abstract

For a long time, no antigenic properties were attributed to insulin. Up to the present, it remains controversial whether insulin is a weak or a strong antigen. On the one hand, hormones were not regarded as antigens due to their species-unspecific biological activity, while on the other hand, insulin is a very small molecule in comparison with other proteins. Indeed, Lewis (1937) was able to demonstrate that guinea-pig uterus, immunized with bovine or porcine insulin, reacted by contracting in the presence of the antigen (Schultz-Dale technique). Haurowitz (1950), however, still considered the antigenic property of insulin quite improbable.

Keywords

Human Insulin Bovine Insulin Insulin Antibody Porcine Insulin Insulin Allergy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1971

Authors and Affiliations

  • Konrad Federlin
    • 1
  1. 1.Medizinisch-Naturwissenschaftliche Hochschule, Zentrum für Innere Medizin und KinderheilkundeUniversität UlmUlm/DonauGermany

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