Skip to main content
SpringerLink
Log in

Irradiation with open (incorporated) radio-isotopes

  • Chapter
Allgemeine Strahlentherapeutische Methodik / Methods and Procedures of Radiation Therapy

Part of the book series: Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology ((1527,volume 16 / 2))

  • 32 Accesses

Abstract

In the early 1930’s, the discovery of artificial radioactivity was universally greeted by a burst of enthusiasm as a possible solution to many therapeutic radiological problems. Even more realistically, especially from an economic viewpoint, the availability of the products of the chain reactor in the middle 1940’s seemed to open up much wider vistas in the field of radiation therapy. Now one was offered an assortment of isotopes of practically all the existing elements as a means of combatting malignant disease by means of application of newly existent radioactive elements as well as nuclide containing compounds which could be tailor-made according to the desires of the investigator. However, real progress has been exasperatingly slow. Attempts to find the reason why by questioning of competent investigators in the field on two continents have failed to reveal a definitive answer. With such a large potential armamentarium available there should be suggested a question of lack of ingenuity and interest. In spite of the tremendous amounts of money which have been expended to develop chemotherapeutic agents for control of malignant processes the results have been very disappointing. Therefore, radiation alone and as an adjuvant to surgery still holds tremendous possibilities in the management of cancer until such a time as a major “break-through” in cancer therapy may be effected by other means. The situation is not dissimilar to that which existed fifteen years ago when the reactor products were first made available and there may well be another equal or longer period of time during which such nuclides could be advantageously used in the treatment of cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • A. M. A. Council on Pharmacy and Chemistry. New and non-official remedies. J. Amer. med. Ass. 159, 1294 (1955).

    Google Scholar 

  • Andrews, G. A.: Therapeutic use of artificial radioisotopes, edit. P. F. Hahn. New York: John Wiley & Sons 1956.

    Google Scholar 

  • Beierwaltes, W. H., P. C. Johnson and A. J. Solari: Clinical use of radioisotopes. Philadelphia: W. B. Saunders Company 1957.

    Google Scholar 

  • Chevalier, A., and C. Burg: Personal communication to author.

    Google Scholar 

  • Dameshek, W. : Physiopathology and course of polycythemia vera as related to therapy. J. Amer. med. Ass. 142, 700–797 (1950).

    Article  Google Scholar 

  • Dickson, K. J., and E. K. Lang: Treatment of papillomata of the bladder with radioactive colloidal gold Au 198. Amer. J. Roentgenol. 83, 116–122 (1960).

    PubMed  CAS  Google Scholar 

  • Duffy, B. J.: Can radiation cause thyroid cancer? J. clin. Endocr. 17, 1383–1388 (1957).

    Article  PubMed  Google Scholar 

  • Ellis, F., and R. Oliver: Treatment of papilloma of bladder with radioactive colloidal gold Au 198. Brit. med. J. 1955 I, 136–139.

    Article  Google Scholar 

  • Fellinger, K., u. H. Vetter: Radioaktive Isotope in Klinik und Forschung. Strahlentherapie Sonderbd. 33, 175–182 (1955).

    Google Scholar 

  • Flocks, R. H., D. A. Culp, H. B. Elkins and T.C. Evans : Therapeutic use of artificial radioisotopes, edit. P. F. Hahn. New York: John Wiley & Sons 1956.

    Google Scholar 

  • Freedberg, A. S., G.S.Kurland and H.L. Blumgart: The pathologic effects of I 131 on the normal thyroid gland of man. J. clin. Endocr. 12, 1315–1348 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Goldie, H., and P. F. Hahn: Effects of radioactive iodine on free sarcoma 37 cells in peritoneal fluid of mouse. Proc. Soc. exp. Biol. (N.Y.) 74, 634–638 (1950).

    CAS  Google Scholar 

  • Hahn, P. F.: Artificial radioisotope therapy. New York: Academic Press 1951.

    Google Scholar 

  • — Therapeutic use of artificial radioisotopes, edit. P. F. Hahn. New York: John Wiley & Sons 1956.

    Google Scholar 

  • — Treatment of cancer and allied diseases. I. Principals of treatment, edit. G. T. Pack and I. M. Ariel. New York: Paul B. Hoeber 1958.

    Google Scholar 

  • — The adjuvant therapy of bronchogenic carcinoma following pneumonectomy or lobectomy with the intrathroracic introduction of silver-coated radioactive colloidal gold. Stuttgart: F. K. Schattauer 1960.

    Google Scholar 

  • —, and E. L. Carothers: Radioactive metallic gold colloids coated with silver and their distribution in lung and its lymphatics following intra-pulmonary administration; therapeutic implications in primary lung and bronchogenic tumors. Brit. J. Cancer 5, 400–404 (1951).

    Article  PubMed  CAS  Google Scholar 

  • — —and H.Brummitt: Synergistic effect of internal irradiation and phlebotomy on production of cirrhosis and ascites in dogs. Amer. J. Physiol. 175, 162–166 (1953).

    PubMed  CAS  Google Scholar 

  • Hahn, P. F., E. L. Carothers, G. W. Hilliard, L. Bernard and M. A. Jackson: Therapeutic use of artificial radioisotopes. New York: John Wiley & Sons 1956.

    Google Scholar 

  • — J. P. B. Goodell, C. W. Sheppard, R. O. Cannon and H. C. Francis: Direct infiltration of radioactive isotopes as means of delivering ionizing radiation to discrete tissues. J. Lab. clin. Med. 32, 1442—1453 (1947).

    PubMed  CAS  Google Scholar 

  • — D.G. Lareau, B. L. Feaster, E.L.Caro thers, F. Gollan, G. R. Meneely and D. Sherman : Intravenous radioactive gold in the treatment of chronic leukemia. Comparison of results with conventional roentgen therapy to the splenic area. Acta radiol. (Stockh.) 50, 565–572 (1958).

    Article  CAS  Google Scholar 

  • — G. R. Meneely and E. L. Carothers: The use of gold and silver-coated radioactive gold colloids in the palliation of ascites and pleural effusions. Brit. J. Radiol. 31, 240–245 (1958).

    Article  PubMed  CAS  Google Scholar 

  • — E. B. Wells and G. R. Meneely : Circulating red cell mass in polycythemia vera as determined by red blood cells tagged with radioactive isotope of iron. Sth. med. J. (Bgham, Ala.) 43, 947–950 (1950).

    Article  Google Scholar 

  • —, and G.H.Whipple: Iron metabolism; its absorption, storage utilization in experimental anemia. Amer. J. med. Sci. 191, 24–42 (1936).

    Article  CAS  Google Scholar 

  • Hamilton, J. G., M. H. Soley and K. B. Eichhorn : Deposition of radioactive iodine in human thyroid tissue. Univ. Calif. Publ Pharmacol. 1, 339–367 (1940).

    CAS  Google Scholar 

  • Hertz, S., and A. Roberts: Radioactive iodine as indicator in thyroid physiology; use of radioactive iodine in differential diagnosis of 2 types of Grave’s disease. J. clin. Invest. 21, 31–32 (1942).

    Article  PubMed  CAS  Google Scholar 

  • Hursh, J. B., and J. W. Karr: Manual of artificial radioisotope therapy. New York: Academic Press 1951.

    Google Scholar 

  • Jacobs, M.L. : Radioactive colloidal chromic phosphate to control pleural effusion and ascites. J. Amer. med. Ass. 166, 597–599 (1958).

    Article  CAS  Google Scholar 

  • Jaffe, H.L.: Treatment of malignant serous effusions with radioactive colloidal chromic phosphate. Amer. J. Roentgenol. 74, 657–666 (1955).

    PubMed  CAS  Google Scholar 

  • Keetel, W. C, and H. B. Elkins : Experience with radioactive colloidal gold in treatment of ovarian carcinoma. Amer. J. Obstet. 71, 553–568 (1956).

    Google Scholar 

  • Kent, E. M., and C. J. Moses: Radioactive isotopes in palliative management of carcinomatosis of pleura. J. thorac. Surg. 22, 503–516 (1951).

    PubMed  CAS  Google Scholar 

  • Keston, A. S., R.-P. Ball, Z. K. Frantz and W. W. Palmer: Storage of radioactive iodine in metastasis from thyroid carcinoma. Science 95, 362–363 (1942).

    Article  PubMed  CAS  Google Scholar 

  • Kottmeier, H. L., and G. Moberger: Experience with radioactive colloidal gold as additional treatment in radiotherapy of uterine cancer. Acta obstet, gynec. scand. 34, 1–29 (1955).

    Article  CAS  Google Scholar 

  • Lange, K. H., J. L. Shields and H. M. Rozen-DAAL : Colloidal radioactive chromic phosphate in control of malignant effusions. N.Y. St. J. Med. 56, 1928–1931 (1956).

    CAS  Google Scholar 

  • Lawrence, J. H.: Polycythemia. New York: Grune & Stratton 1955.

    Google Scholar 

  • — N.I.Berlin and E. L. Huff: Nature and treatment of polycythemia; studies on 263 patients. Medicine (Baltimore) 32, 323–388 (1953).

    CAS  Google Scholar 

  • — K.G.Scott and J. W. Tuttle: Studies on leukemia with aid of radioactive phosphorus. New int. Clin. 3, 33–58 (1939).

    Google Scholar 

  • Matuska, E. A., P. F. Hahn, E. I. Carlson, S. H. Auerbach and G. E. Meneely: Lymphatic drainage of silvercoated radioactive gold colloid following intrathoracic administration to pneumonectomized dogs. J. thorac. Surg. 30, 525–530 (1955).

    PubMed  CAS  Google Scholar 

  • ————— Further observations on the

    PubMed  CAS  Google Scholar 

  • Meneely, G. E., S. H. Auerbach, C. C. Woodcock, E. C. KoRY and P. F. Hahn: Transbronchial instillation of radioactive gold colloid in the lung of the dog. Distribution studies, survival and pathology. Amer. J. med. Sci. 225, 172 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Moore, E.V., D.Gamble and E.L. Libby: Experiences with radioactive chromic phosphate in urologicai tumors. A.M.A. Arch. Surg. 72, 464–468 (1956).

    Article  CAS  Google Scholar 

  • Müller, J. H. : Über die Verwendung von künstlichen radioaktiven Isotopen zur Erzielung von lokalisierten biologischen Strahlenwirkungen. Experientia (Basel) 1, 199–200 (1945).

    Article  Google Scholar 

  • — Über die multiplen Anwendungsmöglichkeiten eines langlebigen künstlichen radioaktiven Isotops (Co-60) in flüssiger Form für die Strahlentherapie maligner Tumoren. Schweiz. med. Wschr. 79, 547–551 (1949).

    PubMed  Google Scholar 

  • — Therapeutic use of artificial radioisotopes, edit. P.F. Hahn. New York: John Wiley & Sons 1956.

    Google Scholar 

  • Myant, N.B.: Therapeutic use of artificial radioisotopes, edit. P. F. Hahn. New York: John Wiley & Sons 1956.

    Google Scholar 

  • Nylander, P. E. A., E. Laustela, T. M. Scheinin and M. Turunen : Observations on the use of radioactive gold (Au 198) in the treatment of malignant tumours of the lungs and pleura. Ann. Med. exp. Fenn. 34, 352–361 (1956).

    PubMed  CAS  Google Scholar 

  • Osgood, E.E.: Therapeutic use of artificial radioisotopes, edit. P. F. Hahn. New York: John Wiley & Sons 1956.

    Google Scholar 

  • Pochin, E.E.: Therapeutic use of artificial radioisotopes, edit. P. F. Hahn. New York: John Wiley & Sons 1956.

    Google Scholar 

  • — N. B. Myant and B. D. Corbett: Leukaemia following radioiodine treatment of hyperthyroidism. Brit. J. Radiol. 29, 31–35 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Quimby, E.B.: Artificial radioisotope therapy, edit. P. F. Hahn. New York: Academic Press 1951.

    Google Scholar 

  • Quimby, E.H., S. Feitelberg and S. Silver: Radioactive isotopes in clinical practice. Philadelphia: Lea and Febiger 1958.

    Google Scholar 

  • Rawson, R. W., L. D. Marinelli, B. N. Skanse, J. B. Trunnell and R. G. Fluharty: Effect of total thyroidectomy on function of metastatic thyroid cancer. J. clin. Endocr. 8, 826–841 (1948).

    Article  PubMed  CAS  Google Scholar 

  • —, and J. B. Trunnell: Artificial radioisotope therapy, edit. P. F. Hahn. New York: Academic Press 1951.

    Google Scholar 

  • Rusche, C, and H.L. Jaffe: Palliative treatment of prostatic cancer with radioactive colloidal chromic phosphate; 3 years experience and results. J. Urol. (Baltimore) 74, 393–401 (1955).

    CAS  Google Scholar 

  • Seidlin, S. M., L. D. Marinelli and E. Oshry: Radioactive iodine therapy: effect on functioning metastases of adenocarcinoma of thyroid. J. Amer. med. Ass. 132, 838–847 (1946).

    Article  CAS  Google Scholar 

  • Shelley, H., and P.F.Hahn: Unpublished data.

    Google Scholar 

  • Sherman, A. I.: Therapeutic use of artificial radioisotopes, edit. P. F. Hahn. New York: John Wiley & Sons 1956.

    Google Scholar 

  • Simon, N.: Radioactive gold treatment; results in 85 effusions due to cancer. J. Mt Sinai Hosp. 22, 96–98 (1955).

    CAS  Google Scholar 

  • Smithers, D. W., D. M. Wallace and N. G. Trott: Therapeutic use of artificial radioisotopes, edit. P. F. Hahn. New York: John Wiley & Sons 1956.

    Google Scholar 

  • Stroebel, C.S., and B.E.Hall: Artificial radioisotope therapy, edit. P. F. Hahn. New York: Academic Press 1951.

    Google Scholar 

  • Walton, R. J., and W. K. Sinclair: Intracavitary irradiation with radioactive colloidal gold in palliative treatment of malignant pleural and peritoneal effusions. Brit. med. Bull. 8, 165–172 (1952).

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. P. F. Hahn
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Düsseldorf, Deutschland

    H. Vieten

  2. München, Deutschland

    F. Wachsmann

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hahn, P.F. (1971). Irradiation with open (incorporated) radio-isotopes. In: Vieten, H., Wachsmann, F. (eds) Allgemeine Strahlentherapeutische Methodik / Methods and Procedures of Radiation Therapy. Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology, vol 16 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80605-6_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80605-6_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80606-3

  • Online ISBN: 978-3-642-80605-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation