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Anterior Pituitary Function in Human Fetal Life

  • P. Franchimont
  • J. J. Legros
  • B. Deconinck
  • P. Demeyts
  • M. Goulart
  • J. M. Ketelslegers
  • C. Schaub
Part of the Symposion der Deutschen Gesellschaft für Endokrinologie in Ulm vom 26.—28. Februar 1970 book series (ENDOKRINOLOGIE, volume 16)

Summary

Anterior pituitary hormones appear very early in the human fetal hypophysis: HGH at 9 weeks, FSH at 14 weeks, LH at 18 weeks, TSH at 14–l6 weeks and ACTH at 16–22 weeks of gestation. These hypophyseal stimulins do not induce organ genesis but are necessary for further development of the already formed organs. Some mechanisms of secretion of these hormones are already identical to those operative in adults: increase in HGH in response to insulin-induced hypoglycemia; decrease in HGH in response to hyperglycemia produced by oral glucose load; negative feedback of the corticosteroids on ACTH secretion.

The levels of HGH, FSH, LH, TSH and ACTH in the serum of premature neonates are very high. The elevated HGH concentrations must be linked to the fall in blood sugar. With regard to serum FSH levels, which are higher in female than in male premature infants, these are elevated in comparison to maternal serum levels and the serum levels of normal one year-old children. Serum LH is probably of pituitary and placental origin. Serum TSH concentrations are high but are of the same order of magnitude as in normal full term neonates. Lastly, ACTH levels are often extremely high and may be correlated with the stress of delivery.

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References

  1. Apostolakis, M.: Acta endocr. (Kbh.) 49, 1 (1965).Google Scholar
  2. Atwell, W. J.: Amer. J. Anat. 31, 159 (1926).CrossRefGoogle Scholar
  3. Ben-David, M., Dikstein, S., Sulman, F. G.: Proc. Soc. exp. Biol. 117, 511 (1964).PubMedGoogle Scholar
  4. Benirshke, K., McKay, D. G.: Obstet. and Gynec. 1, 638 (1953).Google Scholar
  5. Blissard, R. M., Albert, M..: J. Pediat. 48, 782 (1956).CrossRefGoogle Scholar
  6. Brewer, D. B.: J. Path. Bact. 73, 59 (1957).CrossRefGoogle Scholar
  7. Chadwick, A., Folley, S. J., Gemzell, C. A.: Lancet 2, 241 (1961).PubMedCrossRefGoogle Scholar
  8. Cornblath, M., Parker, M., Reisner, S., Forbes, A., Daughaday, W. H.: J. clin. Endocr. 25, 209 (1965).PubMedCrossRefGoogle Scholar
  9. Courrier, R., Colonge, A., Baclesse, M.: C. R. Acad. Sci. (Paris) 233, 336 (1951).Google Scholar
  10. Davis, E., Plötz, E.: Endocrinology 54, 384 (1954).PubMedCrossRefGoogle Scholar
  11. Edmonds, H. W.: Arch. Path. 50, 727 (1950).Google Scholar
  12. Falin, L. I.: Acta anat. (Basel) 44, 196 (1961).CrossRefGoogle Scholar
  13. Ferguson, K. A., Wallace, A. L.: Nature (Lond.) 190, 632 (1961).CrossRefGoogle Scholar
  14. Fisher, J. A., Odell, W. D.: J. clin. Invest. 48, 1670 (1969).PubMedCrossRefGoogle Scholar
  15. Franchimont, P.: Le Dosage des Hormones Somatotrope et Gonadotropes et son Application en Clinique, Brussels: Arscia; Paris: Maloine 1966.Google Scholar
  16. Gala, R. R., Reece, R. P.: Proc. Soc. exp. Biol. 115, 1030 (1964).PubMedGoogle Scholar
  17. Geiger et al., this volume, 1970.Google Scholar
  18. Gemzell, C.: Acta endocr. (Kbh.) 17, 100 (1954).Google Scholar
  19. Ghilain, A., Sehers, J.: C. R. Soc. Biol. (Paris) 151, 1606 (1957).Google Scholar
  20. Gitlin, D., Biasucci, A.: J. clin. Endocr. 29, 849 (1969a).PubMedCrossRefGoogle Scholar
  21. ——: J. clin. Endocr. 29, 926 (1969b).PubMedCrossRefGoogle Scholar
  22. Grumbach, M. M., Kaplan, S. L., Sciarra, J. J., Burr, I. M.: Ann N.Y. Acad. Sci. 148, 501 (1968).PubMedCrossRefGoogle Scholar
  23. Hennen, G. H., Pierce, J. G., Freichet, P.: J. clin. Endocr. 29, 581 (1969).PubMedCrossRefGoogle Scholar
  24. Herlant, M., Pasteels, J. L.: In: Bajusz, E., and G. Jasmin (eds.). Methods and Achievements in Experimental Pathology, vol. 3, p. 250, New York: Karger, 1967.Google Scholar
  25. Hermanus, J. P., Pasteels, J. L., Herlant, M.: C. R. Acad. Sci. (Paris) 259 6530 (1964).Google Scholar
  26. Ivanova, E. A., Levina, S. E.: Dokl. Akad. Nauk SSSR, Otd. Biokh. 167, 1423 (1966).Google Scholar
  27. Jost, A.: In G. W. Morris, and B. T. Donovan (eds.): The Pituitary Gland, vol. 2, p. 299, London: Butterworths, 1966.Google Scholar
  28. Jost, A., Jacquot, R., Cohen, A.: C. R. Soc. Biol. (Paris) 149, 1319 (1955).Google Scholar
  29. Kaplan, S. L., Grumbach, M. M.: J. clin. Endocr. 22, 1153 (1962).CrossRefGoogle Scholar
  30. Kawahara, H.: J. clin. Endocr. 18, 325 (1958).PubMedCrossRefGoogle Scholar
  31. Keene, M. F. L., Hewer, E. E.: Lancet 2, 111 (1924).CrossRefGoogle Scholar
  32. Lemarchand, T., this volume, 1970.Google Scholar
  33. Levina, S. E., Ivanova, E. A.: Dokl. Akad. Nauk. SSSR, Otd. Biokh. 153, 493 (1963). - Dokl. Akad. Nauk SSSR, Otd. Biokh. 155, 988 (1964). - Dokl. Akad. Nauk SSSR, Otd. Biokh. 167, 717 (1966).Google Scholar
  34. Leznoff, A. L., Fishman, J., Goodfriend, L., McGarry, E., Beck, J., Rose, B.: Proc. Soc. exp. Biol. 104, 232 (1960).PubMedGoogle Scholar
  35. Milkovic, K., Milkovic, S, In Martini, L., and W. Ganong (eds.): Neuroendocrinology, vol. 1, p. 371, New York: Academic Press, 1966.Google Scholar
  36. Mitskevich, M. S.: Dokl. Akad. Nauk SSSR, Otd. Biokh. 70, 165 (1950).Google Scholar
  37. Nicoll, C. S., Meites, J.: Endocrinology 70, 272 (1962a) - Endocrinology 70, 927 (1962b). - Proc. Soc. exp. Biol. 117, 579 (1964).PubMedCrossRefGoogle Scholar
  38. Novak, M., Melichar, V. Hahn, P., Koldovsky, O.: Physiol. bohemoslov. 10, 451 (1961).Google Scholar
  39. Pasteels, J. L.: Arch. Biol. (Liège) 74, 439 (1963). - C. R. Acad. Roy. Med. Belg. (2nd series) 7, 1 (1968).Google Scholar
  40. Pasteels, J. L., Bossaert, Y., Brauman, H., Brauman, J.: J. Microsc. (Paris) 4, 158 (1965).Google Scholar
  41. Pasteels, J. L.: Brauman, H., Brauman, J.: C. R. Acad. Sci. (Paris) 256, 2031 (1963).Google Scholar
  42. Pasteels, J. L., Ectors, F.: C. R. Acad. Sci. (Paris) 264, 106 (1967).Google Scholar
  43. Pavlova, E. B., Pronina, T. S., Skebeskaya, Y. B.: Gen. Comp. Endocr. 10, 269 (1968).PubMedCrossRefGoogle Scholar
  44. Raïhä, N., Hjelt, L.: Acta paediat. scand. 72, 610 (1957).CrossRefGoogle Scholar
  45. Reid, J. R.: J. Pediat. 56, 658 (1960).PubMedCrossRefGoogle Scholar
  46. Schmidt, I., Hoffmann, R. A.: Endocrinology 55, 125 (1954).PubMedCrossRefGoogle Scholar
  47. Shepard, T. H.: J. clin. Endocr. 27, 945 (1967). - In: Gardner, L. I. (ed.). Endocrine and Genetic Diseases of Childhood, p. 204, Philadelphia: W. Saunders, 1969.PubMedCrossRefGoogle Scholar
  48. Simkin, B., Goodart, D.: J. clin. Endocr. 20, 1095 (1960).PubMedCrossRefGoogle Scholar
  49. Talwalker, P. K., Ratner, A., Meites, J.: Amer. J. Physiol. 205, 213 (1963).PubMedGoogle Scholar
  50. Taylor, N. R., Loraine, J. A., Robertson, H. A.: J. Endocr. 9, 23 (1953).CrossRefGoogle Scholar
  51. Thompson, K. W., Vincent, M. M., Jensen, F. C., Price, R. T., Shapiro, E.: Proc. Soc. exp. Biol. 102, 403 (1959).PubMedGoogle Scholar
  52. Walaas, W., Waalas, O.: Acta Path. microbiol. scand. 21, 640 (1944).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg New York 1970

Authors and Affiliations

  • P. Franchimont
    • 1
    • 2
  • J. J. Legros
    • 1
    • 3
  • B. Deconinck
    • 1
    • 4
  • P. Demeyts
    • 1
    • 5
  • M. Goulart
    • 1
    • 6
  • J. M. Ketelslegers
    • 1
    • 7
  • C. Schaub
    • 1
    • 8
  1. 1.Department of Internal Medicine and Medical PathologyUniversity of LiègeBelgium
  2. 2.Radioimmunoassay Laboratory, Department of Internal Medicine and Medical Pathology (Prof. Van Cauwenberge)Hôpital de BavièreLiègeBelgium
  3. 3.Department of Internal Medicine and Medical Pathology (Prof. Van Cauwenberge)Hôpital de BavièreLiègeBelgium
  4. 4.Hôtal Calmette (Prof. Gaudier)University >Department of Pediatrics, Hôpiof LilleFrance
  5. 5.Department of Internal Medicine and Medical Pathology (Prof. Van Cauwenberge)Hôpital de BavièreLiègeBelgium
  6. 6.Department of Medical ChemistrySecretaria SaudeRio de JaneiroBrazil
  7. 7.Department of Internal Medicine and Semiology (Prof. Nizet)Hôpital de BavièreLiègeBelgium
  8. 8.Department of Neurosurgery and Laboratory of PsychophysiologyUniversity of ParisFrance

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