Produktion und Stoffwechsel der übrigen Steroidhormone während der Präpubertät und Pubertät

  • W. Blunck
Part of the Symposion der Deutschen Gesellschaft für Endokrinologie in Ulm vom 26.—28. Februar 1970 book series (ENDOKRINOLOGIE, volume 16)

Production and Metabolism of the Other Steroid Hormones during Prepuberty and Puberty

Summary

In both sexes production of progesterone, 17-OH-progesterone and estrogens predominantly depends on gonadotrophic stimulation and is directly related to sexual maturation. Little is known about the physiological significance of these steroids for sexual development of the male.

The production of Cortisol, corticosterone and aldosterone is apparently independent of sexual maturation. There are, however, changes of metabolism and excretion. These concern the increased conversion to 11-hydroxylated 17-ketosteroids and an increased rate of sulfatation of C19-steroids. The apparently high corticosterone excretion rates in early childhood must be corroborated by the determination of production-rates.

The comparatively low excretion of the 5α-reduced cortisolmetabolite allo- THF and the shift of the allo-THF/THF-ratio during sexual maturation is not satisfactorily explained by an introduction of the 5α-reduction pathway (“puberty of the rat liver”).

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Copyright information

© Springer-Verlag Berlin Heidelberg New York 1970

Authors and Affiliations

  • W. Blunck
    • 1
  1. 1.Universitäts-Kinderklinik Hamburg-EppendorfDeutschland

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