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Testosteron und Pubertät bei Knaben

  • D. Knorr
Part of the Symposion der Deutschen Gesellschaft für Endokrinologie in Ulm vom 26.—28. Februar 1970 book series (ENDOKRINOLOGIE, volume 16)

Testosterone and Puberty in Males

Summary

Modern methods like gas liquid chromatography (GLC) and protein binding technique provided the opportunity to measure testosteron (T) in urine, plasma and testicular tissue.

T. glucoronide is found in urine in very low levels just before the onset of puberty [less than 5μg/d]. Urinary T. glucoronide in children and in females derives primarily from dehydroepiandrosterone.

Starting at the age of 9–10 years urinary T. excretion increases up to the mean value of 70 μg/d in the adult male. In the age group 17 and I8 years, the mean T. excretion is below the mean of adult males.

Plasma T in prepuberty is <5 ng/100 ml. Plasma T of the adult male is 470–1050 ng/100 ml. The significant rise of T during puberty occurs normally after the age of 12 years.

T production rates during puberty are not investigated very well. The T production rate in the adult male is about 6 mg/d, in females 0,3 mg/d. Testicular tissue T. during puberty is investigated in rats.

Testosterone secretion can be stimulated by chorionic gonadotrophin (HCG) also before puberty. Plasma testosterone in boys rises to the adult level within two weeks stimulated by 15OO U. HCG every other day independent from age. (Between the age of 3–15 years).

Testosterone secretion before puberty is limited not only by the deficiency of enzymes needed for testosterone synthesis but also by enzymes reducing testosterone to andròstandiole.

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Copyright information

© Springer-Verlag Berlin Heidelberg New York 1970

Authors and Affiliations

  • D. Knorr
    • 1
  1. 1.Universitäts-KinderklinikMünchenDeutschland

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