Enzyme des Steroidhormonstoffwechsels bei Hemmung der sexuellen Entwicklung
The Influence of Disturbed Sexual Development on the Activity of Enzymes of the steroid Metabolism
Decisive enzymes of the metabolism of steroid hormones in the rat liver are sex-dependent. Treatment of male rats with the anti-androgen cyproterone-acetate during the first sixty days of life lowers the activity of 3β-hydroxysteroid dehydrogenase and 20-keto reductase but leaves the activity of Δ4-5α-hydrogenase unchanged. From this one can conclude that in the cases of 3β-hydroxy-steroid dehydrogenase and 20-keto reductase androgens function as enzyme inductors. The low Δ4-5α-hydrogenase activity, typical for the male sex, is not due to a repressive action of androgens. Interference vith sexual differentiation by giving testosterone propionate to female and oestradiol benzoate to male rats on day 5 of life leads to an inversion of the activity pattern of the above cited enzymes, inasmuch as male animals exhibit a female-type activity pattern and female animals a male one.