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General Pharmacology pp 96–105Cite as

Kinetics of Drug Action

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Part of the book series: Handbuch der Experimentellen Pharmakologie ((HEP,volume 4))

Abstract

It is very easy to make fairly accurate measurements of the rate of action on a cell population of a parti­cular concentration of drug (time-action curve) and from a series of such curves, which cover an adequate range of concentrations, the relation between con­centration and the time until a selected action appears (time-concentration curve) can be determined.

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References

  1. Bayliss, W. M.: Proc. roy. Soc. B. 84, 81 (1911).

    Article  Google Scholar 

  2. Noyes, A. A., and W. R. Whitney: Z. physik. Chem. 23, 689 (1897); 35, 283 (1900).

    Google Scholar 

  3. Brunner, E.: Z. anorg. u. allg. Chem. 28, 314 (1901); 35, 23; 37, 455 (1903)

    Google Scholar 

  4. Brunner, E.: Z. physik. Chem. 47, 56 (1906).

    Google Scholar 

  5. Penman: Chem. Soc. Trans. 73, 511 (1898).

    Article  Google Scholar 

  6. Clark, A. J.: The Mode of Action of Drugs and Cells. London: Arnold and Co. 1933.

    Google Scholar 

  7. Gann, J. A.: Kolloid-Beih. 8, 64 (1916).

    Google Scholar 

  8. Arrhenius, S.: Quantitative Laws in Biological Chemistry. London: Bell and Sons 1915.

    Book  Google Scholar 

  9. Gasser, IL S.: Physiologic. Rev. 10, 35 (1930).

    Google Scholar 

  10. Brunner, E.: Z. physik. Chem. 47, 56 (1906).

    Google Scholar 

  11. Davis, H. S., and G. S. Crandall: J. amer. chem. Soc. 52, 3757 (1930).

    Article  CAS  Google Scholar 

  12. Bernheim, F., and A. Gorfain: Pharmacol. Baltimore 52, 338 (1934).

    CAS  Google Scholar 

  13. Webster, M. D.: J. Pharmacol. Baltimore 53, 340 (1935).

    CAS  Google Scholar 

  14. Brown, G. L., and J. C. Eccles: J. of Physiol. 82, 211, 242 (1934).

    CAS  Google Scholar 

  15. Ing, H. R., and W. M. Wright: Proc. roy. Soc. B. 109, 337 (1932).

    Article  Google Scholar 

  16. Cooper, E. A.: Biochemie. J. 6, 362 (1912).

    CAS  Google Scholar 

  17. Hartridge, H., and F. J. W. Houghton: J. of Physiol. 62, 232 (1927).

    CAS  Google Scholar 

  18. Osterlmout, W. J. V.: Erg. Physiol. 35, 967 (1933).

    Google Scholar 

  19. BrooksM. M.: Protoplasma 1, 305 (1926).

    Article  Google Scholar 

  20. Irwin, M.: J. gen. Physiol. 8, 147 (1925/26).

    Article  Google Scholar 

  21. Hoagland, D. R., P. L. Hibbard and A. R. Davis: J. gen. Physiol. 10, 121 (1926/27).

    Article  PubMed  CAS  Google Scholar 

  22. Jacques, A. G., and W. J. V. Ostereout: J. gen. Physiol. 13, 695 (1929/30).

    Article  PubMed  CAS  Google Scholar 

  23. Brooks, M. M.: Amer. J. Physiol. 76, 360 (1926).

    CAS  Google Scholar 

  24. Field, J., and S. M. Field: Proc. Soc. exper. Biol. a. Med. 29, 733 (1931).

    Google Scholar 

  25. Lundsoaard, E.: Biochem. Z. 220, 1 (1930).

    Google Scholar 

  26. Liindsgaard, E.: Biochem. Z. 217, 162 (1930).

    Google Scholar 

  27. Ghaffar, A.: Quart. J. exper. Physiol. 25, 61 (1935).

    CAS  Google Scholar 

  28. Lohmann, K.: Biochem. Z. 230, 444 (1931).

    Google Scholar 

  29. Clark, A. J., M. G. Eggleton and P. Eggletox: J. of Physiol. 75, 332 (1932).

    CAS  Google Scholar 

  30. Porongo, T. M.: Ber. dtsch. Bot. Ges. 44, 71 (1926).

    Google Scholar 

  31. Hill, A. V.: J. of Physiol. 39, 361 (1909).

    CAS  Google Scholar 

  32. Boehm, R.: Heffters Handb exper. Pharmakol. 2, 187 (1920).

    Google Scholar 

  33. Boehm, R.: Arch. f. exper. Path. 63, 219 (1910).

    Google Scholar 

  34. Hartridge, H. and F. J. W. Rouoaton: J. of Physiol. 62, 232 (1927).

    CAS  Google Scholar 

  35. Langenbeck, W.: Erg. Physiol. 35, 470 (1933).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Edinburgh, Scotland

    A. J. Clark

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  1. A. J. Clark
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© 1937 Verlag von Julius Springer

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Clark, A.J. (1937). Kinetics of Drug Action. In: General Pharmacology. Handbuch der Experimentellen Pharmakologie, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80555-4_12

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  • DOI: https://doi.org/10.1007/978-3-642-80555-4_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80557-8

  • Online ISBN: 978-3-642-80555-4

  • eBook Packages: Springer Book Archive

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