Perspectives of Glaucoma Treatment by Potentiation of a Beta-Agonist

  • L. Bonomi
  • S. Perfetti
  • R. Bellucci
  • F. Massa
  • G. C. Gamba
Conference paper
Part of the Symposion der Deutschen Ophthalmologischen Gesellschaft vom 22. bis 24. April 1982 in Würzburg book series (OPH.GES.)

Summary

Terbutaline, a selective adrenergic agonist for beta2-receptors, significantly reduces IOP both in the rabbit and in man without producing unwanted side effects. Its efficacy, however, is insufficient for use in glaucoma therapy.

The association of the drug with low-dose guanethidine produces a manifold potentiation of its IOP-lowering effect.

In patients suffering from open-angle glaucoma, the association of 0.5–0.3% guanethidine and 0.3–0.1% terbutaline produces a 21-23% pressure reduction without affecting pupil, accomodation, blood pressure or heart rate.

Its local tolerance is very good.

The potentiation of a beta2-agonist by means of association with low-dose guanethidine would therefore appear to offer sound prospects in terms of future clinical use in glaucoma therapy.

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Copyright information

© J.F. Bergmann Verlag, München 1982

Authors and Affiliations

  • L. Bonomi
    • 1
  • S. Perfetti
    • 1
  • R. Bellucci
    • 1
  • F. Massa
    • 1
  • G. C. Gamba
    • 1
  1. 1.VeronaItaly

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