Skip to main content

The Clinical Use of Acyclovir in the Treatment of Herpes Simplex Corneal Ulceration

  • Conference paper

Summary

Thirtyeight patients with herpes corneal ulceration were treated on a randomized double-blind basis with Acyclovir or Vidarabine ointment respectively. The results of this study indicate that Acyclovir is at least as good as Ara-A, and is effective in the treatment of IDU and Ara-A resistant ulcers.

Zusammenfassung

Achtunddreißig Patienten mit virologisch bestätigtem epithelialen Herpes corneae wurden in einer randomisierten Doppelblindstudie entweder mit Acyclovir- oder Vidarabin-Salbe behandelt Die vorliegenden Ergebnisse zeigen, daß Acyclovir mindestens so gut wie Vidarabin ist und darüber hinaus auch bei IDU- und Vidarabin-resistenten Keratitiden wirkt.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bauer DJ, Collins P (1978) Activity of 9-(2-Hydroxyethoxymethyl)guanine against herpes virus infections in animal models. Antimicrob Agents Chemother Abstr 73

    Google Scholar 

  2. Bauer DJ, Collins P, Tucker WE, Macklin AW (1979) Treatment of experimental herpes simplex keratitis with acycloguanosine. Br J Ophthalmol 63: 429–435

    Article  PubMed  CAS  Google Scholar 

  3. Collins P, Tisdale SM, Furman PA (1979) Electron microscopic study of the effect of Acyclovir on the In Vitro replication of herpes simplex virus. International Congress of Chemotherapy, Boston, Abstr 253

    Google Scholar 

  4. Coster DJ, McKinnon JR, McGill JI, Jones BR, Fraunfelder FT (1976) Clinical evaluation of adenine arabinoside and trifluorothymidine in the treatment of corneal ulcers caused by herpes simplex virus. J Infect Dis Suppl 133: A173–A177

    Article  PubMed  Google Scholar 

  5. Elion GB, Furman PA, Fyfe JA, Miranda P de, Beauchamp L, Schaeffer HJ (1977) Selectivity or Trifluorothymidine resistance. Side effects such as topical toxicity or clinical resistance can occur, so it is of interest to see how Acyclovir compares with it. of action of an antiherpetic agent 9-(2-hydroxyethoxymethyl)guanine. Proc Natl Acad Sci USA 74: 5716–5720

    Article  PubMed  CAS  Google Scholar 

  6. Falcon MG, Jones BR (1979) Acycloguanosine: antiviral activity in the rabbit cornea. Br J Ophthalmol 63: 422–424

    Article  PubMed  CAS  Google Scholar 

  7. Field HJ, Darby GK, Wildy P (1979) Pathogenicity for mice of acycloguanosine-resistant mutants of herpes simplex virus. Interscience Congress of Chemotherapy, Boston, Abstr 257

    Google Scholar 

  8. Furman PA, Collins P, McGuirt P (1979) The effect of Acyclovir on viral polypeptide synthesis in herpes simplex virus type I infected cells. International Congress of Chemotherapy, Boston, Abstr 252

    Google Scholar 

  9. Furman PA, St Clair MH, Fyfe JA, Rideout JL, Keller PM, Elion GB (1979) Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate. J Virol 32: 72–77

    PubMed  CAS  Google Scholar 

  10. Jones BR, Fison PR, Cobo LM, Coster DJ, Thompson CM, Falcon MC (1979) Efficacy of acycloguanosine (Wellcome 248U) against herpes corneal ulcers. Lancet 1: 241–242

    Google Scholar 

  11. Kaufman HE, Varnell ED, Centifanto YM, Rheinstrom SD (1978) Effect of 9-(2-hydroxy- ethoxymethyl)guanine on herpesvirus- induced keratitis and iritis in rabbits. Antimicrob Agents Chemother 14: 842–845

    PubMed  CAS  Google Scholar 

  12. Klein RJ, Friedman-Kien AE, Destefano E (1979) Latent herpes simplex virus infections in sensory ganglia of hairless mice prevented by Acycloguanosine. Antimicrob Agents Chemother 15: 723–729

    PubMed  CAS  Google Scholar 

  13. McGill J, Fraunfelder FT, Jones BR (1976) Current and proposed management of ocular herpes simplex. Surv Ophthalmol: 358–365

    Google Scholar 

  14. O’Meara A, Deasy PF, Hillaiy IB, Brigden WD (1979) Acyclovir for treatment of mucocutaneous herpes infection in a child with leu-kaemia. Lancet 2: 1196

    Article  PubMed  Google Scholar 

  15. Pavan-Langston D, Dohlman CH (1972) A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis. Am J Ophthalmol 74: 81–88

    PubMed  CAS  Google Scholar 

  16. Schaeffer HJ, Beauchamp L, Miranda P de, Elion GB, Bauer DJ, Collins P (1978) 9-(2-hydroxyethoxymethyl)guanine activity against viruses of the herpes group. Nature 272: 583–585

    Article  PubMed  CAS  Google Scholar 

  17. Selby RJ, Jameson B, Watson JG, Morgenstern G, Powles RL, Kay HEM, Thornton R, Clink HM, McElwain TJ, Prentice HG, Ross MG, Corringham R, Hofíbrand AV, Brigden D (1979) Parenteral acyclovir therapy for herpesvirus infections in man. Lancet 2: 1267–1269

    Article  PubMed  CAS  Google Scholar 

  18. Shiota H, Inoue S, Yamane S (1979) Efficacy of acycloguanosine against herpetic ulcers in rabbit cornea. Br J Ophthalmol 63: 425–428

    Article  PubMed  CAS  Google Scholar 

  19. Schnipper LE, Crumpacker CS (1979) Mechanism of action of the anti-herpes viral agent, acycloguanosine; requirement of viral thymidine kinase and DNA polymerase activities. Clin Res 27: 356A

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 J.F. Bergmann Verlag, München

About this paper

Cite this paper

McGill, J., Tormey, P., Walker, C. (1981). The Clinical Use of Acyclovir in the Treatment of Herpes Simplex Corneal Ulceration. In: Sundmacher, R. (eds) Herpetische Augenerkrankungen. Internationales Symposion der Deutschen Ophthalmologischen Gesellschaft vom 12. bis 14. April 1980 in Freiburg. J.F. Bergmann-Verlag. https://doi.org/10.1007/978-3-642-80499-1_51

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80499-1_51

  • Publisher Name: J.F. Bergmann-Verlag

  • Print ISBN: 978-3-8070-0324-5

  • Online ISBN: 978-3-642-80499-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics