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The Clinical Use of Acyclovir in the Treatment of Herpes Simplex Corneal Ulceration

  • J. McGill
  • P. Tormey
  • C. Walker
Conference paper
Part of the Internationales Symposion der Deutschen Ophthalmologischen Gesellschaft vom 12. bis 14. April 1980 in Freiburg book series (OPH.GES.)

Summary

Thirtyeight patients with herpes corneal ulceration were treated on a randomized double-blind basis with Acyclovir or Vidarabine ointment respectively. The results of this study indicate that Acyclovir is at least as good as Ara-A, and is effective in the treatment of IDU and Ara-A resistant ulcers.

Key words

Dendritic keratitis acyclovir ara-A resistant ulcers IDU 

Zusammenfassung

Achtunddreißig Patienten mit virologisch bestätigtem epithelialen Herpes corneae wurden in einer randomisierten Doppelblindstudie entweder mit Acyclovir- oder Vidarabin-Salbe behandelt Die vorliegenden Ergebnisse zeigen, daß Acyclovir mindestens so gut wie Vidarabin ist und darüber hinaus auch bei IDU- und Vidarabin-resistenten Keratitiden wirkt.

Schlüsselwörter

Keratitis dendritica Acyclovir ara-A IDU therapieresistenter Oberflächenherpes 

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References

  1. 1.
    Bauer DJ, Collins P (1978) Activity of 9-(2-Hydroxyethoxymethyl)guanine against herpes virus infections in animal models. Antimicrob Agents Chemother Abstr 73Google Scholar
  2. 2.
    Bauer DJ, Collins P, Tucker WE, Macklin AW (1979) Treatment of experimental herpes simplex keratitis with acycloguanosine. Br J Ophthalmol 63: 429–435PubMedCrossRefGoogle Scholar
  3. 3.
    Collins P, Tisdale SM, Furman PA (1979) Electron microscopic study of the effect of Acyclovir on the In Vitro replication of herpes simplex virus. International Congress of Chemotherapy, Boston, Abstr 253Google Scholar
  4. 4.
    Coster DJ, McKinnon JR, McGill JI, Jones BR, Fraunfelder FT (1976) Clinical evaluation of adenine arabinoside and trifluorothymidine in the treatment of corneal ulcers caused by herpes simplex virus. J Infect Dis Suppl 133: A173–A177PubMedCrossRefGoogle Scholar
  5. 5.
    Elion GB, Furman PA, Fyfe JA, Miranda P de, Beauchamp L, Schaeffer HJ (1977) Selectivity or Trifluorothymidine resistance. Side effects such as topical toxicity or clinical resistance can occur, so it is of interest to see how Acyclovir compares with it. of action of an antiherpetic agent 9-(2-hydroxyethoxymethyl)guanine. Proc Natl Acad Sci USA 74: 5716–5720PubMedCrossRefGoogle Scholar
  6. 6.
    Falcon MG, Jones BR (1979) Acycloguanosine: antiviral activity in the rabbit cornea. Br J Ophthalmol 63: 422–424PubMedCrossRefGoogle Scholar
  7. 7.
    Field HJ, Darby GK, Wildy P (1979) Pathogenicity for mice of acycloguanosine-resistant mutants of herpes simplex virus. Interscience Congress of Chemotherapy, Boston, Abstr 257Google Scholar
  8. 8.
    Furman PA, Collins P, McGuirt P (1979) The effect of Acyclovir on viral polypeptide synthesis in herpes simplex virus type I infected cells. International Congress of Chemotherapy, Boston, Abstr 252Google Scholar
  9. 9.
    Furman PA, St Clair MH, Fyfe JA, Rideout JL, Keller PM, Elion GB (1979) Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate. J Virol 32: 72–77PubMedGoogle Scholar
  10. 10.
    Jones BR, Fison PR, Cobo LM, Coster DJ, Thompson CM, Falcon MC (1979) Efficacy of acycloguanosine (Wellcome 248U) against herpes corneal ulcers. Lancet 1: 241–242Google Scholar
  11. 11.
    Kaufman HE, Varnell ED, Centifanto YM, Rheinstrom SD (1978) Effect of 9-(2-hydroxy- ethoxymethyl)guanine on herpesvirus- induced keratitis and iritis in rabbits. Antimicrob Agents Chemother 14: 842–845PubMedGoogle Scholar
  12. 12.
    Klein RJ, Friedman-Kien AE, Destefano E (1979) Latent herpes simplex virus infections in sensory ganglia of hairless mice prevented by Acycloguanosine. Antimicrob Agents Chemother 15: 723–729PubMedGoogle Scholar
  13. 13.
    McGill J, Fraunfelder FT, Jones BR (1976) Current and proposed management of ocular herpes simplex. Surv Ophthalmol: 358–365Google Scholar
  14. 14.
    O’Meara A, Deasy PF, Hillaiy IB, Brigden WD (1979) Acyclovir for treatment of mucocutaneous herpes infection in a child with leu-kaemia. Lancet 2: 1196PubMedCrossRefGoogle Scholar
  15. 15.
    Pavan-Langston D, Dohlman CH (1972) A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis. Am J Ophthalmol 74: 81–88PubMedGoogle Scholar
  16. 16.
    Schaeffer HJ, Beauchamp L, Miranda P de, Elion GB, Bauer DJ, Collins P (1978) 9-(2-hydroxyethoxymethyl)guanine activity against viruses of the herpes group. Nature 272: 583–585PubMedCrossRefGoogle Scholar
  17. 17.
    Selby RJ, Jameson B, Watson JG, Morgenstern G, Powles RL, Kay HEM, Thornton R, Clink HM, McElwain TJ, Prentice HG, Ross MG, Corringham R, Hofíbrand AV, Brigden D (1979) Parenteral acyclovir therapy for herpesvirus infections in man. Lancet 2: 1267–1269PubMedCrossRefGoogle Scholar
  18. 18.
    Shiota H, Inoue S, Yamane S (1979) Efficacy of acycloguanosine against herpetic ulcers in rabbit cornea. Br J Ophthalmol 63: 425–428PubMedCrossRefGoogle Scholar
  19. 19.
    Schnipper LE, Crumpacker CS (1979) Mechanism of action of the anti-herpes viral agent, acycloguanosine; requirement of viral thymidine kinase and DNA polymerase activities. Clin Res 27: 356AGoogle Scholar

Copyright information

© J.F. Bergmann Verlag, München 1981

Authors and Affiliations

  • J. McGill
    • 1
  • P. Tormey
    • 1
  • C. Walker
    • 1
  1. 1.SouthamptonUK

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