Summary
Changes in levels of immune globulins IgA and IgG in human tears were investigated in 22 patients suffering from herpetic dendritic keratitis, in 6 patients with herpetic disciform keratitis, in 3 patients with herpetic iridocyclitis, in 62 patients with adenovirus conjunctivitis and in 100 healthy persons. It appeared that in the case of herpetic dendritic keratitis, the level of IgA decreased and that of IgG increased in human tears. In herpetic disciform keratitis, IgA increased and IgG slightly increased. In herpetic iridocyclitis, IgA slightly increased while IgG increased considerably. Adenovirus conjunctivitis caused a high increase in both IgA and IgG levels of human tears. It is inferred that in herpetic diseases of the eye the levels of immune globulins in human tears increase only if the herpetic disease spreads over tissues with good blood supply while in diseases of the cornea, there is little change in the levels of immune globulins.
Zusammenfassung
Schwankungen des Immunglobulin-A und Immunglobulin-G-Gehalts in der Tränenflüssigkeit wurden bei 22 Patienten mit Keratitis dendritica, 6 Patienten mit Keratitis disciformis, 3 Patienten mit herpetischer Iridocyclitis, 62 Patienten mit Adenoviruskonjunktivitis und 100 gesunden Kontrollpersonen untersucht. Dabei zeigte sich, daß bei der Keratitis dendritica der Ig- A-Spiegel erniedrigt und der Ig-G Spiegel in der Tränenflüssigkeit erhöht war. Bei der Keratitis disciforms fanden wir Ig-A erhöht und Ig-G leicht erhöht. Bei der herpetischen Iridocyclitis war Ig-A leicht erhöht, während Ig-G beträchtlich erhöht war. Eine Adenoviruskonjunktivitis führte sowohl zu einem hohen Anstieg des Ig-A als auch des Ig- G-Spiegels in der Tränenflüssigkeit. Wir schließen hieraus, daß bei herpetischen Augenerkrankungen die Immunglobulinspiegel in den Tränen nur dann ansteigen, wenn Gewebe mit guter Blutversorgung erkrankt sind, während es bei Hornhauterkrankungen nur geringe Schwankungen im Immunoglobulinspiegel gibt.
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© 1981 J.F. Bergmann Verlag, München
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Tapasztó, I. (1981). Changes of Immune Globulins in Different Herpetic Diseases. In: Sundmacher, R. (eds) Herpetische Augenerkrankungen. Internationales Symposion der Deutschen Ophthalmologischen Gesellschaft vom 12. bis 14. April 1980 in Freiburg. J.F. Bergmann-Verlag. https://doi.org/10.1007/978-3-642-80499-1_25
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DOI: https://doi.org/10.1007/978-3-642-80499-1_25
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