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Herpesviruses — Common Properties and Heterogeneity

  • D. Neumann-Haefelin
  • R. Sundmacher
Conference paper
Part of the Internationales Symposion der Deutschen Ophthalmologischen Gesellschaft vom 12. bis 14. April 1980 in Freiburg book series (OPH.GES.)

Summary

The natural occurrence of herpes viruses has been demonstrated within a broad range of animal species. All herpes viruses share typical properties of the group, such as common morphology and the ability to establish persistent infections. Nevertheless, the different herpes viruses of man (HSV 1 and 2, VZV, CMV and EBV) as well as those of animals are quite distinct from each other. Immunological cross-reactivity and molecular DNA studies have shown that there is more affinity between biologically similar herpes viruses of different host species than between different herpes viruses of one individual species (except HSV 1 and HSV 2). All members of the herpes virus group studied so far display an extensive heterogeneity of strains. Sixty-three corneal HSV 1 isolates were compared for intratypic strain differences. Studies of biological properties (neurovirulence in mice) and biochemical analysis (DNA cleavage with restriction endonucleases) revealed considerable differences between individual strains. Attempts to correlate biological and biochemical strain characteristics with clinical features failed. One explanation for this outcome may be that many other pathophysiological factors are involved in the pathogenesis of herpetic diseases. Nevertheless, further studies on the heterogeneity of viral strains are considered necessary for elucidation of the pathogenesis of herpetic diseases.

Key words

Herpes viruses — physical and biological properties HSV-1 strain specificity and heterogeneity dendritic keratitis 

Zusammenfassung

Herpesviren kommen im gesamten Bereich der Wirbeltiere vor und besitzen ohne Unterschied die Strukturmerkmale der Herpesvirusgruppe:

Das komplette Virus besteht aus dem von einer lipidhaltigen Membran umschlossenen Ikosaederformigen Nucleocapsid (ca. 100 nm Durchmesser; 162 Capsomere) und enthält als Virus-Genom einen DNS-Doppelstrang mit einem Molekulargewicht von ca. 100 Millionen. Die allen Herpesviren gemeinsame wichtigste biologische Eigenschaft ist ihre Fähigkeit, persistierende Infektionen hervorzurufen. Abgesehen von diesen Gemeinsamkeiten sind die menschlichen Herpesviren, Herpes simplex Virus Typ 1 und Typ 2 (HSV 1 und 2), Varizellen-Zoster Virus (VZV), Zytomegalievirus (CMV), Epstein-Barr Virus (EBV) ebenso wie die tierischen Herpesviren sehr verschieden.

Schlüsselwörter

Herpesviren — physikalische und biologische Eigenschaften HSV-Stammeigenschaften und Heterogenität Keratitis dendritica 

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Copyright information

© J.F. Bergmann Verlag, München 1981

Authors and Affiliations

  • D. Neumann-Haefelin
    • 1
  • R. Sundmacher
    • 1
  1. 1.FreiburgGermany

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