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PDZ Domains and the Formation of Protein Networks at the Plasma Membrane

  • Chapter
Protein Modules in Signal Transduction

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 228))

Abstract

Protein-protein associations are the basis of much of the macromolecular organization underlying cellular structure and function. Two general mechanisms exist to achieve binding specificity: “surface-surface” and “modular domain-peptide” associations. The former is based on interacting surface chemistry unique to each pair of binding partners, e.g., oligomerization of hemoglobin monomers. Surface-surface interactions provide for highly specific binding, but the complex nature of these associations has not provided evolution with the opportunity to generate binding diversity. In contrast, “modular domain-peptide” associations are based on conserved domains which recognize variations of simple peptide motifs. Both the modular domains and peptide targets are found as motifs within multidomain proteins of diverse function, e.g., enzymes, receptors, cytoskeletal proteins. Examples of these domains include the well characterized SH3, SH2 and PTB domains.

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References

  • Ahn AH, Yoshida M, Anderson MS, Feener CA, Selig S, Hagiwara Y, Ozawa E, Kunkel LM (1994) Cloning of human basic Al, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23–24. Proc Natl Acad Sci USA 91:4446–4450

    Article  PubMed  CAS  Google Scholar 

  • Ahn AH, Freener CA, Gussoni E, Yoshida M, Oxawa E, Kunkel LM (1996) The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. J Biol Chem 271:2724–2730

    Article  PubMed  CAS  Google Scholar 

  • Anbudurai PR, Mor TS, Ohad I, Shestakov SV, Pakrasi HB (1994) The ctpA gene encodes the C-terminal processing protease for the D1 protein of the photosystem II reaction center complex. Proc Natl Acad Sci USA 91:8082–8086

    Article  PubMed  CAS  Google Scholar 

  • Anderson JM (1996) MAGUK magic. Curr Biol 6:326–329

    Article  Google Scholar 

  • Anderson B, Sims K, Regnery R, Robinson L, Schmidt MJ, Goral S, Hager C, Edwards K (1994) Detection of Rochalimaea henselae DNA in specimens from cat scratch disease patients by PCR. J Clin Microbiol 32:942–948

    PubMed  CAS  Google Scholar 

  • Apperson ML, Moon IS, Kennedy MB (1996) Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family. J Neurosci 16:6839–6852

    PubMed  CAS  Google Scholar 

  • Bannert N, Baier M, Werner A, Kurth R (1996) Interleukin-16 or not? Nature 381:30

    Article  PubMed  CAS  Google Scholar 

  • Bass S, Gu Q, Christen A (1996) Multicopy suppressors of pre mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated RlpA. J Bacteriol 178:1154–1161

    PubMed  CAS  Google Scholar 

  • Baumler AJ, Kusters JG, Stojiljkovic I, Heffron F (1994) Salmonella typhimurium loci involved in survival within macrophages. Infect Immun 62:1623–1630

    PubMed  CAS  Google Scholar 

  • Bhanot P, Brink M, Samos CH, Hsieh J, Wang Y, Macke JP, Andrew D, Nathans J, Nüsse R (1996) A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382:225–230

    Article  PubMed  CAS  Google Scholar 

  • Boucher JC, Martinez-Salazar J, Schurr MJ, Mudd MH, Yu H, Deretic V (1996) Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA. J Bacteriol 178:511–523

    PubMed  CAS  Google Scholar 

  • Brand SN, Tan X, Widger WR (1992) Cloning and sequencing of the petBD operon from the cyanbo- bacterium Synechococcus sp. PCC 7002. Plan Mol Biol 20:481–491

    Article  CAS  Google Scholar 

  • Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF et al (1996) Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and al-syntrophin mediated by PDZ domains. Cell 84:757–767

    Article  PubMed  CAS  Google Scholar 

  • Cho K, Hunt CA, Kennedy MB (1992) The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9:929–942

    Article  PubMed  CAS  Google Scholar 

  • Cohen NA, Brenman JE, Snyder SH, Bredt DS (1996) Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. Neuron 17:759–767

    Article  PubMed  CAS  Google Scholar 

  • Cruikshank WW, Center DM, Nisar N, Wu M, Natke BC, Theodore AC, Kornfeld H (1994) Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression. Proc Natl Acad Sci USA 91:5109–5113

    Article  PubMed  CAS  Google Scholar 

  • Devereux J, Haeberli P, Smithies O (1984) A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res 12:387–395

    Article  PubMed  CAS  Google Scholar 

  • Dimitratos Sd, Woods DF, Bryant PJ (1997) Camguk, Lin-2 and CASK: novel membrane-associated guanylate kinase homologs that also contain CaM kinase domains. Mech Dev (in press)

    Google Scholar 

  • Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R (1996) Crystal structure of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 85:1067–1076

    Article  PubMed  CAS  Google Scholar 

  • Duclos F, Boschert U, Sirugo G, Mandel JL, Hen R, Koenig M (1993) Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system. Proc Natl Acad Sci USA 90:109–113

    Article  PubMed  CAS  Google Scholar 

  • Duclos F, Rodius F, Wrogemann K, Mandel JL, Koenig M (1994) The Friedreich Ataxia region: characterization of two novel genes and reduction of the critical region to 300kb. Hum Mol Genet 3:909–914

    Article  PubMed  CAS  Google Scholar 

  • Ehlers MD, Tingley WG, Huganir RL (1995) Regulated subcellular distribution of the NR1 subunit of the NMD A receptor. Nature 269:1734–1737

    CAS  Google Scholar 

  • Ehlers MD, Mammen AL, Lau L, Huganir RL (1996) Synaptic targeting of glutamate receptors. Curr Opin Cell Biol 8:484–489

    Article  PubMed  CAS  Google Scholar 

  • Etemad-Moghadam B, Guo S, Kemphues KJ (1995) Asymmetrically distrubuted PAR-3 protein contributes to cell polarity and pindle alignment in early C. elegans embryos. Cell 83:743–752

    Article  PubMed  CAS  Google Scholar 

  • Fanning AS, Anderson JM (1996) Protein-protein interactions: PDZ domain networks. Curr Biol 6:1385–1388

    Article  PubMed  CAS  Google Scholar 

  • Fanning AS, Lapierre LA, Brecher AR, Van Itallie CM, Anderson JM (1996) Protein interactions in the tight junction: the role of MAGUK proteins in regulating tight junction organization and function. Curr Top Membr 43:211–235

    Article  CAS  Google Scholar 

  • Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb J-F, Dougherty BA, Merrick JM et al (1995) Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269 (5223):496–512

    Article  PubMed  CAS  Google Scholar 

  • Gatehouse JA, Lycett GW, Croy RR, Boulter D (1982) The post-translational proteolysis of the subunits of vicilin from pea (Pisum sativum L.). Biochem J 207:629–632

    PubMed  CAS  Google Scholar 

  • Glazebrook J, Ichige A, Walker GC (1996) Genetic analysis ofRhizobium meliloti bacA-phoA fusion results in identification of degP: two loci required for symbiosis are closely linked to degP. J Bacteriol 178:745–752

    PubMed  CAS  Google Scholar 

  • Gomperts SN (1996) Clustering membrane proteins: it’s all coming together with the PSD-95/SAP90 protein family. Cell 84:659–662

    Article  PubMed  CAS  Google Scholar 

  • Gu M, York JD, Warshawsky I, Majerus PW (1991) Identification, cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein4.1. Proc Natl Acad Sci USA 88:5867–5871

    Article  PubMed  CAS  Google Scholar 

  • Gumbiner BT, Lowenkopf, Apatira D (1991) Identification of 160-kDa polypeptide that binds to the tight junction protein ZO-1. Proc Natl Acad Sci USA 88:3460–3464

    Article  PubMed  CAS  Google Scholar 

  • Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A, Collard JG (1994) Identification of an invasion-inducing gene, Tiam-1 that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell 77:537–549

    Article  PubMed  CAS  Google Scholar 

  • Harrison SC (1996) Peptide-surface association: the case of PDZ and PTB domains. Cell 86:341–343

    Article  PubMed  CAS  Google Scholar 

  • Hata Y, Butz S, Sudhof TC (1996a) CASK: a novel dlg/PDZ95 homolog with an N-terminal calmodulindependent protein kinase domain identified by interaction with neurexins. J Neurosci 16:2488–2494

    PubMed  CAS  Google Scholar 

  • Hata Y, Butz S, Sudhof TC (1996b) CASK: a novel dlg/PSD95 homologue with an N-terminal CaM kinase domain identified by interaction with neurexins. J Neurosci 16:2488–2494

    PubMed  CAS  Google Scholar 

  • Hoskins R, Hajinal A, Harp S, Kim SK (1995) The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins. Development 122:97–111

    Google Scholar 

  • Inagaki N, Yamamoto Y, Mori H, Satoh K (1996) Carboxyl-terminal processing protease for the D1 precursor protein: cloning and sequencing of the spinach cDNA. Plant Mol Biol 30:39–50

    Article  PubMed  CAS  Google Scholar 

  • Jesaitis LA, Goodenough DA (1994) Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J Cell Biol 124:949–961

    Article  PubMed  CAS  Google Scholar 

  • Johnson K, Charles I, Dougan G, Pickard D, O’Gaora P, Costa G, Ali T, Miller I, Hormaeche C (1991) The role of a stress-response protein inSalmonella typhimurium virulence. Mol Microbiol 5:401–407

    Article  PubMed  CAS  Google Scholar 

  • Kiess M, Scharm B, Aguzzi A, Hajnal A, Klemenz R, Schwarte-Waldhoff I, Schafer R (1995) Expression of ril, a novel LIM domain gene, is down-regulated in Hras-transformed cells and restored in phenotypic revertants. Oncogene 10:61–68

    PubMed  CAS  Google Scholar 

  • Kim E, Niethammer M, Rothschild A, Jan YN, Sheng S (1995) Clustering of the Shaker-type K + channels by direct interaction with the PSD-95/SAP90 family of membrane-associated guanylate kinases. Nature 378:85–88

    Article  PubMed  CAS  Google Scholar 

  • Kim E, Cho KO, Rothschild A, Sheng M (1996) Heteromultimerization and NMD A receptor clustering activity of chapsyn-110, a novel member of the PSD-95 family of synaptic proteins. Neuron 17:103–113

    Article  PubMed  CAS  Google Scholar 

  • Kim E, Naisbitt S, Hseuh Y-P, Rao A, Rothschild A, Craig AM, Sheng M (1997) GKA, a novel synaptic protein that interacts with the guanylate Kinase-like domain of the PSD95/SAP90 family of channel clustering molecules. J Cell Biol 136:669–678

    Article  PubMed  CAS  Google Scholar 

  • Kistner U, Wenzel BM, Veh RW, Cases-Langhoff C, Garner AM, Appeltauer U, Voss B, Gundelfinger ED, Garner CC (1993) SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J Biol Chem 268:4580–4583

    PubMed  CAS  Google Scholar 

  • Kistner U, Garner CC, Linial M (1995) Nucleotide binding by the synapse associated protein SAP90. FEBS Let 359:159–163

    Article  CAS  Google Scholar 

  • Kligensmith J, Yang Y, Axelrod JD, Beier DR, Perrimon N, Sussman DJ (1996) Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Mech Dev 58:15–26

    Article  Google Scholar 

  • Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995) Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269:1737–1740

    Article  PubMed  CAS  Google Scholar 

  • Lipinska B, Sharma S, Georgopoulos C (1988) Sequence analysis and regulation of the htrA gene of Escherichia coli: a sigma 32-independent mechanism of heat-inducible transcription. Nucleic Acids Res 16:10053–10067

    Article  PubMed  CAS  Google Scholar 

  • Lipinska B, Fayet O, Baird L, Georgopoulos C (1989) Identification, characterization, and mapping of theEscherichia coli htrA gene, whose product is essential for bacterial growth only at elevated temperatures. J Bacteriol 171:1574–1584

    PubMed  CAS  Google Scholar 

  • Lipinska B, Zylicz M, Georgopoulos C (1990) The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase. J Bacteriol 172:1791–1797

    PubMed  CAS  Google Scholar 

  • Lue RA, Marfatia SM, Branton D, Chishti AH (1994) Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc Natl Acad Sci USA 91:9818–9822

    Article  PubMed  CAS  Google Scholar 

  • Lue RA, Brandin E, Chan EP, Branton D (1996) Two independent domains of hDlg ar§ sufficient for subcellular targeting: the PDZ 1–2 conformational unit and an alternatively spliced domain. J Cell Biol 135:1125–1137

    Article  PubMed  CAS  Google Scholar 

  • Maekawa K, Imagawa N, Nagamatsu M, Harada S (1994) Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats. FEBS Lett 337:200–206

    Article  PubMed  CAS  Google Scholar 

  • Marfatia SM, Morais Cabral JH, Lin L, Hough C, Bryant PJ, Stolz L, Chishti AH (1996) Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domain-binding proteins to ATP and the membrane cytoskeleton. J Cell Biol 135:753–766

    Article  PubMed  CAS  Google Scholar 

  • Matsumine A, Ogai A, Senda T, Okumura N, Satoh K, Baeg GH, Kawahara T, Kobayashi S, Okada M, Toyoshima K et al (1996) Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science 272:1020–1023

    Article  PubMed  CAS  Google Scholar 

  • Mazoyer S, Gayther SA, Nagai MA, Smith SA, Dunning A, vanRensburg EJ, Albertsen H, White R, Ponder BAJ (1995) A gene (DLG2) located at 17ql2-q21 encodes a new homologue of the Drosophila tumor suppressor dlg-A. Genomics 28:25–31

    Article  PubMed  CAS  Google Scholar 

  • Miyamoto H, Nihonmatsu I, Kondo S, Ueda R, Togashi S, Hirata K, Ikegami Y, Yamamoto D (1995) Canoe encodes a novel protein containing a GLGF/DHR motif and functions with Notch and scabrous in common developmental pathways in Drosophila. Genes Dev 9:612–625

    Article  PubMed  CAS  Google Scholar 

  • Mizuno K, Okano I, Ohashi K, Nunoue K, Kuma K, Miyata T, Nakamura T.(1994) Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif. Oncogene 9:1605–1612

    PubMed  CAS  Google Scholar 

  • Morias-Cabral JH, Petosa C, Sutcliffe MJ, Raza S, Byron O, Poy F, Marfatia SM, Chishti AH, Liddington RC (1996) Crystal structure of a PDZ domain from the human homolog of discs-large protein. Nature 384:649–652

    Article  Google Scholar 

  • Müller BM, Kistner U, Veh RW, Cases-Langhoff C, Becker B, Gundelfinger ED, Garner CC (1995) Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. J Neurosci 15:2354–2366

    PubMed  Google Scholar 

  • Müller BM, Bistner U, Kindler S, Chung WK, Kuhlendahl S, Fenster SD, Lau L, Veh RW, Huganir RL, Gundelfinger ED et al. (1996) SAP 102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Neuron 17:255–265

    Article  PubMed  Google Scholar 

  • Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (1995) Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res 2:167–174

    Article  PubMed  CAS  Google Scholar 

  • Nakane M, Schmidt HHHW, Pollock JS, Forstermann U, Murad F (1993) Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett 316:175–180

    Article  PubMed  CAS  Google Scholar 

  • Niethammer M, Kim E, Sheng M (1996) Interaction between the C-terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci 16:2157–2163

    PubMed  CAS  Google Scholar 

  • Pizzuti A, Novelli G, Man A, Ratti A, Colosimo A, Amati F, Penso D, Sangiuolo F, Calabrese G, Palka G et al. (1996) Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome. Am J Hum Genet 58:722–729

    PubMed  CAS  Google Scholar 

  • Prasad R, Gu Y, Alder H, Nakamura T, Canaani O, Saito H, Huebner K, Gale RP, Nowell PC, Kuriyama K et al (1993) Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;ll) chromosome translocation. Cancer Res 53:5624–5628

    PubMed  CAS  Google Scholar 

  • Ruff P, Speicher DW, Husain-Chishti A (1991) Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif. Proc Natl Acad Sci USA 88:6595–6599

    Article  PubMed  CAS  Google Scholar 

  • Saras J, Claesson-Welsh L, Heldin C, Gonez LJ (1994) Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins. J Biol Chem 269:24082–24089

    PubMed  CAS  Google Scholar 

  • Sato T, Irie S, Kitada S, Reed JC (1995) Fap-1: a protein tyrosine phosphatase that associates with Fas. Science 268:411–415

    Article  PubMed  CAS  Google Scholar 

  • Schiaffino MV, Bassi MT, Rugarli EI, Renieri A, Galli L, Ballabio A (1995) Cloning of a human homologue of the Xenopus laevis APX gene from the ocular albinism type 1 critical region. Hum Mol Genet 4:373–382

    Article  PubMed  CAS  Google Scholar 

  • Sheng M (1996) PDZs and receptor/channel clustering: rounding up the latest suspects. Neuron 17:575–578

    Article  PubMed  CAS  Google Scholar 

  • Shestakov SV, Anbudurai PR, Stanbekova GE, Gadzhiev A, Lind LK, Pakrasi HB (1994) Molecular cloning and characterization of the ctpA gene encoding a carboxyl-terminal processing protease. Analysis of a spontaneous photosystem II-deficient mutant strain of the Cyanobacterium Synechocystis sp. PCC 6803. J Biol Chem 269:19354–19359

    PubMed  CAS  Google Scholar 

  • Shieh B, Niemeyer B (1995) A novel protein encoded by the InaD gene regulates recovery of visual transduction inDrosophila. Neuron 14:201–210

    Article  PubMed  CAS  Google Scholar 

  • Shieh BH, Zhu MY (1996) Regulation of the TRP channel by INAD in Drosophila photoreceptors. Neuron 16:991–998

    Article  PubMed  CAS  Google Scholar 

  • Simske JS, Kaech SM, Harp SA, Kim SK (1996) LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. Cell 85:195–204

    Article  PubMed  CAS  Google Scholar 

  • Smith SA, Holik P, Stevens J, Mazoyer S, Melis R, Williams B, White R, Albertsen H (1996) Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17ql2-q21. Genomics 31:145–150

    Article  PubMed  CAS  Google Scholar 

  • Sone M, Hoshino M, Suzuki E, Kuroda S, Kaibuchi K, Nakagoshi H, Saigo K, Nabeshima Y, Hama C (1997) Still life, a protein in synaptic terminals of drosophila homologous to GDP-GTP exchangers. Science 275:543–547

    Article  PubMed  CAS  Google Scholar 

  • Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, Chishti AH, Crompton A, Chan AC, Anderson JM, Cantley LC (1997) Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275:73–77

    Article  PubMed  CAS  Google Scholar 

  • Staudinger J, Zhou J, Burgess R, Elledge SJ, Olson EN (1995) Pickl: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol 128:263–271

    Article  PubMed  CAS  Google Scholar 

  • Sussman DJ, Klingensmith J, Salinas P, Adams PS, Nusse R, Perrimon N (1994) Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. Dev Biol 166:73–86

    Article  PubMed  CAS  Google Scholar 

  • Taguchi F, Yamamoto Y, Satoh K (1995) Recognition of the structure around the site of cleavage by the carboxyl-terminal processing protease for D1 precursor protein of the photosystem II reaction center. J Biol Chem 270:10711–10716

    Article  PubMed  CAS  Google Scholar 

  • Takahisa M, Togashi S, Suzuki T, Kobayashi M, Murayama A, Kondo K, Miyake T, Ueda R (1996) The Drosophila tamou gene, a component of the activating pathway of extramacrochaetae expression, encodes a protein homologous to mammalian cell-cell junction-associated protein ZO-1. Genes Dev 10:1783–1795

    Article  PubMed  CAS  Google Scholar 

  • Tatum FM, Cheville NF, Morfitt D (1994) Cloning, characterization and construction of htrA and htrA-like mutants of Brucella abortus and their survival in BALB/c mice. Microb Pathog 17:23–36

    Article  PubMed  CAS  Google Scholar 

  • Taylor DE, Hiratsuka K (1990) Use of non-radioactive DNA probes for detection of Campylobacter jejuni andCampylobacter coli in stool specimens. Mol Cell Probes 4:261–271

    Article  PubMed  CAS  Google Scholar 

  • Tejedor FJ, Bokari A, Rogero O, Gorczyca M, Zhang J, Kim E, Sheng M, Budnik V (1997) Essential role for dig in synaptic clustering of Shaker K+ channels in vivo. J Neurosci 17:152–159

    PubMed  CAS  Google Scholar 

  • Theisen H, Purcell J, Bennett M, Kansagara D, Syed A, Marsh JL (1994) Dishevelled is required during wingless signaling to establish both cell polarity and cell identity. Development 120:347–360

    PubMed  CAS  Google Scholar 

  • Trofatter JA, MacCollin MM, Rutter JL, Murrell JR, Duyao MP, Parry DM, Eldredge R, Kley N, Menon AG, Pulaski K (1993) A novel moesin, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 72:791–800

    Article  PubMed  CAS  Google Scholar 

  • Walden PD, Cowan NJ (1993) A novel 205-kilodalton testis-speeific serine/threonine protein kinase associated with microtubules of the spermatid manchette. Mol Cell Biol 13:7625–7635

    PubMed  CAS  Google Scholar 

  • Wang H, Harrison-Shostak DC, Lemasters JJ, Herman B (1995) Cloning of a rat cDNA encoding a novel LIM domain protein with high homology to rat RIL. Gene 165:267–271

    Article  PubMed  CAS  Google Scholar 

  • Watanabe G, Saito Y, Madaule P, Ishizaki T, Fujisawa K, Morii N, Mukai H, Ono Y, Kakizuka A, Narumiya S (1996) Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science 271:645–648

    Article  PubMed  CAS  Google Scholar 

  • Weinman EJ, Steplock D, Wang Y, Shenolikar S (1995) Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. J Clin Invest 95:2143–2149

    Article  PubMed  CAS  Google Scholar 

  • Willott E, Balda MS, Fanning AS, Jameson B, Van Itallie C, Anderson JM (1993) The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions. Proc Natl Acad Sci USA 90:7834–7838

    Article  PubMed  CAS  Google Scholar 

  • Woods DF, Bryant PJ (1989) Molecular cloning of the Lethal(l) Discs Large-1 oncogene of Drosophila. Dev Biol 134:222–235

    Article  PubMed  CAS  Google Scholar 

  • Woods DF, Bryant PJ (1991) Thediscs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 66:451–464

    Article  PubMed  CAS  Google Scholar 

  • Wu RY, Gill GN (1994) LIM domain recognition of a tyrosine-containing tight turn. J Biol Chem 269:25085–25090

    PubMed  CAS  Google Scholar 

  • Yang Q, Lijam N, Sussman DJ, Tsang M (1996) Genomic organization of mouse Dishevelled genes. Gene 180:121–123

    Article  PubMed  CAS  Google Scholar 

  • Yang Q, Tonks NK (1991) Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin. Proc Natl Acad Sci USA 88:5949–5953

    Article  PubMed  CAS  Google Scholar 

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  1. Departments of Internal Medicine and Cell Biology, Yale University School of Medicine, PO Box 208019, New Haven, CT, 06520-8019, USA

    A. S. Fanning & J. M. Anderson

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  1. A. S. Fanning
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  1. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada

    Anthony J. Pawson FRS

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Fanning, A.S., Anderson, J.M. (1998). PDZ Domains and the Formation of Protein Networks at the Plasma Membrane. In: Pawson, A.J. (eds) Protein Modules in Signal Transduction. Current Topics in Microbiology and Immunology, vol 228. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80481-6_9

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