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Mechanism and Function of Signaling by the TGFβ Superfamily

  • Chapter
Protein Modules in Signal Transduction

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 228))

Abstract

Transforming growth factor β (TGFβ) was initially identified based on its ability to induce the anchorage-independent growth of normal rat kidney fibroblasts (Roberts et al. 1981). It is now apparent that TGFβ is the founding member of a superfamily of growth and differentiation factors that includes almost 40 members from animals as diverse as C. elegans, Drosophila and humans. The superfamily is generally subdivided into three groups, the prototypic TGFβs, the activins and the bone morphogenetic proteins (BMPs). However, with new members constantly being identified these divisions are becoming increasingly difficult to define. Nevertheless, the study of the biology of this large family has provided us with some interesting and surprising insights into how these factors can regulate a staggering array of diverse developmental and physiological processes. In addition, major advances have been made in elucidating the mechanism of signaling by TGFβ-like factors. In this review we will focus on recent developments in our understanding of TGFβ signaling and on the multiple roles these factors play in controlling inductive interactions and patterning during development.

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Authors and Affiliations

  1. Program in Developmental Biology and Division of Gastroenterology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada

    P. A. Hoodless & J. L. Wrana

  2. Department of Medical Genetics and Microbiology, University of Toronto, Toronto, ON, Canada

    J. L. Wrana

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  1. P. A. Hoodless
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  1. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada

    Anthony J. Pawson FRS

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Hoodless, P.A., Wrana, J.L. (1998). Mechanism and Function of Signaling by the TGFβ Superfamily. In: Pawson, A.J. (eds) Protein Modules in Signal Transduction. Current Topics in Microbiology and Immunology, vol 228. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80481-6_10

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