Advertisement

Functions of SH2 and SH3 Domains

  • B. J. Mayer
  • R. Gupta
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 228)

Abstract

Cells have a remarkable ability to extract information from the extracellular environment and to respond by altering their transcriptional and replication programs, metabolism, shape, and many other aspects of their behavior. The transduction of extracellular signals is particularly crucial in multicellular organisms, where development and adult life requires that each cell precisely adjust its activities to conform to the needs of the whole organism. From an engineering standpoint the mechanisms used to transduce signals must be combinatorial in nature, because the limited number of total gene products implies that the transducers for each specific signal in each specific cell type cannot be unique. Our current understanding suggests that many types of extracellular signals are transduced by a relatively small number of enzymes including tyrosine kinases, GTP-binding proteins, and serine/threonine kinases, and that specificity of signaling arises through the assembly of multiprotein complexes involving such signaling proteins.

Keywords

Pleckstrin Homology Domain Phagocyte NADPH Oxidase Activate Growth Factor Receptor Mitogenic Growth Factor Grb2 Adaptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abo A, Pick E, Hall A, Totty N, Teahan CG, Segal AW (1991) Activation of the NADPH oxidase involves the small GTP-binding protein p21racl. Nature 353:668–670PubMedCrossRefGoogle Scholar
  2. Anderson D, Koch CA, Grey L, Ellis C, Moran MF, Pawson T (1990) Binding of SH2 domains of phospholipase Cγl, GAP, and src to activated growth factor receptors. Science 250:979–982PubMedCrossRefGoogle Scholar
  3. Andoniou CE, Thien CBF, Langdon WY (1994) Tumor induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J 13:4515–4523PubMedGoogle Scholar
  4. Bauer F, Urdaci M, Aigle M, Crouzet M (1993) Alteration of a yeast SH3 protein leads to conditional viability with defects in cytoskeletal and budding patterns. Mol Cell Biol 13:5070–5084PubMedGoogle Scholar
  5. Bender L, Lo HS, Lee H, Kokojan V, Peterson V, Bender A (1996) Associations among PH and SH3 domain-containing proteins and Rho-type GTPases in yeast. J Cell Biol 133:879–894PubMedCrossRefGoogle Scholar
  6. Blake TJ, Shapiro M, Morse HC, Langdon WY (1991) The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene 6:653–657PubMedGoogle Scholar
  7. Bonfini L, Karlovich CA, Dasgupta C, Bannerjee U (1992) The Son of sevenless gene product: a putative activator of Ras. Science 255:603–606PubMedCrossRefGoogle Scholar
  8. Bowtell DDL, Langdon WY (1995) The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation. Oncogene 11:1561–1567PubMedGoogle Scholar
  9. Bromberg Y, Pick E (1985) Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate. J Biol Chem 260:13539–13545PubMedGoogle Scholar
  10. Buday L, Downward J (1993) Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73:611–620PubMedCrossRefGoogle Scholar
  11. Buday L, Khwaja A, Sipeki S, Farago A, Downward J (1996) Interactions of Cbl with two adaptor proteins, Grb2 and Crk, upon T cell activation. J Biol Chem 271:6159–6163PubMedCrossRefGoogle Scholar
  12. Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D (1993) Human Sosl: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260:1338–1343PubMedCrossRefGoogle Scholar
  13. Chenevert J, Corrado K, Bender A, Pringle J, Herskowitz I (1992) A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains. Nature 356:77–79PubMedCrossRefGoogle Scholar
  14. Chou MM, Fajardo JE, Hanafusa H (1992) The SH2- and SH3-containing Nek protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels. Mol Cell Biol 12:5834–5842PubMedGoogle Scholar
  15. Cicchetti P, Mayer BJ, Thiel G, Baltimore D (1992) Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. Science 257:803–806PubMedCrossRefGoogle Scholar
  16. Clark SG, Stern MJ, Horvitz HR (1992) C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature 356:340–344PubMedCrossRefGoogle Scholar
  17. Cohen GB, Baltimore D (1995) Modular binding domains in signal transduction proteins. Cell 80:237–248PubMedCrossRefGoogle Scholar
  18. de Jong R, ten Hoeve J, Heisterkamp N, Groffen J (1995) Crkl is complexed with tyrosine-phosphory-lated Cbl in Ph-positive leukemia. J Biol Chem 270:21468–21471PubMedCrossRefGoogle Scholar
  19. De Leo FR, Ulman KV, Davis AR, Jutila KL, Quinn MT (1996) Assembly of the human neutrophil NADPH oxidase involves binding of p67phox and flovocytochrome b to a common functional domain in p47phox. J Biol Chem 271:17013–17020PubMedCrossRefGoogle Scholar
  20. de Mendez I, Adams AG, Sokolic RA, Malech HL, Leto TL (1996) Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells. EMBO J 15:1211–1220PubMedGoogle Scholar
  21. Eck MJ, Dhe-Paganon S, Trub T, Nolte RT, Shoelson SE (1996) Structure of the IRS-1 PTP domain bound to the juxtamembrane region of the insulin receptor. Cell 85:695–705PubMedCrossRefGoogle Scholar
  22. Feller SM, Knudsen B, Hanafusa H (1994) c-Abl kinase regulates the protein binding activity of c-Crk. EMBO J 13:2341–2351PubMedGoogle Scholar
  23. Feng S, Chen JK, Yu H, Simon J A, Schreiber SL (1994) Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions. Science 266:1241–1247PubMedCrossRefGoogle Scholar
  24. Feng S, Kasahara C, Rickles RJ, Schreiber SL (1995) Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands. Proc Natl Acad Sci USA 92:12408–12415PubMedCrossRefGoogle Scholar
  25. Ferguson KM, Lemmon MA, Sigler PB, Schlessinger J (1995) Scratching the surface with the PH domain. Nature Struct Biol 2:715–718PubMedCrossRefGoogle Scholar
  26. Freeman JL, Lambeth JD (1996) NADPH oxidase assembly is independent of p47phox in vitro. J Biol Chem 271:22578–22582PubMedCrossRefGoogle Scholar
  27. Fuchs A, Dagher M-C, Vignais PV (1995) Mapping the domains of interaction of p40phox with both p47phox and p67phox of the neutrophil oxidase complex using the two-hybrid system. J Biol Chem 270:5695–5697PubMedCrossRefGoogle Scholar
  28. Fuchs A, Dagher M-C, Faure J, Vignais PV (1996) Topological organization of the cytosolic activating complex of the superoxide-generating NADPH oxidase. Pinpointing the sites of interaction between p47phox, p67phox and p40phox using the two-hybrid system. Biochim Biophys Acta 1312:39–47PubMedCrossRefGoogle Scholar
  29. Goodson HV, Anderson BL, Warrick HM, Pon LA, Spudich J A (1996) Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton. J Cell Biol 133:1277–1291PubMedCrossRefGoogle Scholar
  30. Gorina S, Pavletich NP (1996) Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science 274:1001–1005PubMedCrossRefGoogle Scholar
  31. Gotoh T, Hattori S, Nakamura S, Kitayama H, Noda M, Takai Y, Kaibuchi K, Matsui H, Hatase O, Takahashi H, Kurata T, Matsuda M (1995) Identification of Rapl as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol Cell Biol 15: 6746–6753PubMedGoogle Scholar
  32. Harlan JE, Hajduk PJ, Yoon HS, Fesik SW (1994) Pleckstrin homology domains bind to phosphati-dylinositol 4,5-bisphosphate. Nature 371:168–170PubMedCrossRefGoogle Scholar
  33. Harrison SC (1996) Peptide-surface association: the case of PDZ and PTB domains. Cell 86:341–343PubMedCrossRefGoogle Scholar
  34. Holtzman DA, Yang S, Drubin DG (1993) Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskelton assembly in Saccharomyces cerivisiae. J Cell Biol 122:635–644PubMedCrossRefGoogle Scholar
  35. Ito T, Nakamura R, Sumimoto H, Takeshige K, Sakaki Y (1996) An SH3 domain-mediated interaction between the phagocyte NADPH oxidase factors p40phox and p47phox. FEBS Lett 385:229–232PubMedCrossRefGoogle Scholar
  36. Iwabuchi K, Bartel PL, Li B, Marraccino R, Fields S (1994) Two cellular proteins that bind to wild-type but not mutant p53. Proc Natl Acad Sci USA 91:6098–6102PubMedCrossRefGoogle Scholar
  37. Johnson DI, Pringle JR (1990) Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J Cell Biol 111:143–152PubMedCrossRefGoogle Scholar
  38. Karlovich CA, Bonfini L, McCollam L, Rogge RD, Daga A, Czech MP, Bannerjee U (1995) In vivo functional analysis of the Ras exchange factor Son of Sevenless. Science 268:576–579PubMedCrossRefGoogle Scholar
  39. Khwaja A, Hallberg B, Warne PH, Downward J (1996) Networks of interaction of p120-cbl and p130cas with Crk and Grb2 adaptor proteins. Oncogene 12:2491–2498PubMedGoogle Scholar
  40. Kitayama H, Sugimoto Y, Matsuzaki T, Ikawa Y, Noda M (1989) A ras-related gene with transformation suppressor activity. Cell 56:77–84PubMedCrossRefGoogle Scholar
  41. Knaus UG, Heyworth PG, Evans T, Curnutte JT, Bokoch GM (1991) Regulation of phgocyte oxygen radical production by the GTP-binding protein Rac2. Science 254:1512–1515PubMedCrossRefGoogle Scholar
  42. Ladbury JE, Lemmon MA, Zhou M, Green J, Botfield MC, Schlessinger J (1995) Measurement of binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal. Proc Natl Acad Sci USA 92:3199–3202PubMedCrossRefGoogle Scholar
  43. Langdon WY, Hartley JW, Klinken SP, Ruscetti SK, Morse HC (1989) v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc Natl Acad Sci USA 86:1168–1172PubMedCrossRefGoogle Scholar
  44. Lee C-H, Leung B, Lemmon MA, Sheng J, Cowburn D, Kuriyan J, Saksela K (1995) A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV Nef protein. EMBO J 14:5006–5015PubMedGoogle Scholar
  45. Lee C-H, Saksela K, Mirza UA, Chait BT, Kuriyan J (1996) Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell 85.931–942PubMedCrossRefGoogle Scholar
  46. Lemmon MA, Ferguson KM, Sigler PB, Schlessinger J (1995) Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proc Natl Acad Sci USA 92:10472–10476PubMedCrossRefGoogle Scholar
  47. Leto TL, Adams AG, de Mendez I (1994) Assembly of the phagocyte NADPH oxidase: binding of Src homoloy 3 domains to proline-rich targets. Proc Natl Acad Sci USA 91:10650–10654PubMedCrossRefGoogle Scholar
  48. Li W, Hu E, Skolnik EY, Ullrich A, Schlessinger J (1992) The SH2 and SH3 domain-containing Nek protein is oncogenic and a common target for phosphorylation by different surface receptors. Mol Cell Biol 12:5824–5833PubMedGoogle Scholar
  49. Lowenstein EJ, Daly RJ, Betzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnick EY, Bar-Sagi D, Schlessinger J (1992) The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70:431–442PubMedCrossRefGoogle Scholar
  50. Malek SN, Desiderio S (1994) A cyclin-dependent kinase homologue, pl30PITSLRE, is a phosphotyrosine-independent SH2 ligand. J Biol Chem 269:33009–33020PubMedGoogle Scholar
  51. Malek SN, Yang CH, Earnshaw WC, Kozak CA, Desiderio S (1996) pl50TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains. J Biol Chem 271.6952–6962PubMedCrossRefGoogle Scholar
  52. Margolis B, Li N, Koch A, Mohammadi M, Hurwitz DR, Zilberstein A, Ullrich A, Pawson T, Schlessinger J (1990) The tyrosine-phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-y. EMBO J 9:4375–4380PubMedGoogle Scholar
  53. Matsuda M, Mayer BJ, Fukui Y, Hanafusa H (1990) Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. Science 248:1537–1539PubMedCrossRefGoogle Scholar
  54. Matsuda M, Mayer BJ, Hanafusa H (1991) Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins. Mol Cell Biol 11:1607–1613PubMedGoogle Scholar
  55. Matsui Y, Matsui R, Akada R, Tohe A (1996) Yeast src homology 3 domain-binding proteins involved in bud formation. J Cell Biol 133:865–878PubMedCrossRefGoogle Scholar
  56. Mayer BJ, Eck MJ (1995) Minding your p’s and q’s. Curr Biol 5:364–367PubMedCrossRefGoogle Scholar
  57. Mayer BJ, Hanafusa H (1990) Association of the v-crk oncogene product with phosphotyrosine-con-taining proteins and protein kinase activity. Proc Natl Acad Sci USA 87:2638–2642PubMedCrossRefGoogle Scholar
  58. Mayer BJ, Hamaguchi M, Hanafusa H (1988) Characterization of p47gag-crk, a novel oncogene product with sequence similarity to a putative modulatory domain of protein-tyrosine kinases and phospholipase C. Cold Spring Harbor Symp Quant Biol 53:907–914PubMedGoogle Scholar
  59. Mayer BJ, Jackson PK, Baltimore D (1991) The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity. Proc Natl Acad Sci USA 88:627–631PubMedCrossRefGoogle Scholar
  60. Mayer BJ, Hirai H, Sakai R (1995) Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases. Curr Biol 5:296–305PubMedCrossRefGoogle Scholar
  61. Meisner H, Czech MP (1995) Coupling of the proto-oncogene product c-Cbl to the epidermal growth factor receptor. J Biol Chem 270 (43):25332–25335PubMedCrossRefGoogle Scholar
  62. Moran MF, Koch CA, Anderson D, Ellis C, England L, Martin GS, Pawson T (1990) Src homology region 2 domains direct protein-protein interactions in signal transduction. Proc Natl Acad Sci USA 87.8622–8626PubMedCrossRefGoogle Scholar
  63. Muller AJ, Pendergast AM, Havlik MH, Puil L, Pawson T, Witte ON (1992) A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction Mol Cell Biol 12:5087–5093PubMedGoogle Scholar
  64. Musacchio A, Gibson T, Rice P, Thompson J, Saraste M (1993) The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem Sci 18:343–348PubMedCrossRefGoogle Scholar
  65. Nauseef WM, Volpp BD, Clark RA (1990) Immunochemical and electrophoretic analyses of phosphorylated native and recombinant neutrophil oxidase component of p47-phox. Blood 76:2622–2629PubMedGoogle Scholar
  66. Nauseef WM, Volpp BD, McCormick S, Leidal KG, Clark RA (1991) Assembly of the neutrophil respiratory burst oxidase: protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components. J Biol Chem 266:5911–5917PubMedGoogle Scholar
  67. Odai H, Sasaki K, Iwamatsu A, Hanazono Y, Tanaka T, Mitani K, Yazaki Y, Hirai H (1995) The protooncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells. J Biol Chem 270:10800–10805PubMedCrossRefGoogle Scholar
  68. Olivier JP, Raabe T, Henkemeyer M, Dickson B, Mbamalu G, Margolis B, Schlessinger J, Hafen E, Pawson T (1993) A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 73:179–191CrossRefGoogle Scholar
  69. Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H (1996) pl20cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and She adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem 271:3187–3194PubMedCrossRefGoogle Scholar
  70. Park JW, Benna JE, Scott KE, Christensen BL, Chanock SJ, Babior BM (1994) Isolation of a complex of respiratory burst oxidase components from resting neutrophil cytosol. Biochemistry 33:2907–2911PubMedCrossRefGoogle Scholar
  71. Pawson T (1995) Protein modules and signalling networks. Nature 373:573–579PubMedCrossRefGoogle Scholar
  72. Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON (1991) BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell 66:161–171PubMedCrossRefGoogle Scholar
  73. Rameh LE, Chen C-S, Cantley LC (1995) Phosphatidylinositol (3, 4, 5) P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell 83:821–830PubMedCrossRefGoogle Scholar
  74. Ravichandran KS, Lorenz U, Shoelson SE, Burakoff SJ (1995) Interaction of She with Grb2 regulates association of Grb2 with mSos. Mol Cell Biol 15:593–600PubMedGoogle Scholar
  75. Reedquist KA, Fukazawa T, Panchamoorthy G, Langdon WY, Shoelson SE, Druker BJ, Band H (1996) Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J Biol Chem 271:8435–8442PubMedCrossRefGoogle Scholar
  76. Ren R, Mayer BJ, Cicchetti P, Baltimore D (1993) Identification of a 10-amino acid proline-rich SH3 binding site. Science 259:1157–1161PubMedCrossRefGoogle Scholar
  77. Ren R, Ye Z-S, Baltimore D (1994) Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Genes Dev 8:783–795PubMedCrossRefGoogle Scholar
  78. Rickles RJ, Botfield MC, Zhou X-M, Henry PA, Brugge JS, Zoller MJ (1995) Phage display selection of ligand residues important for Src homology 3 domain binding specificity. Proc Natl Acad Sci USA 92:10909–10913PubMedCrossRefGoogle Scholar
  79. Rivero-Lezcano OM, Sameshima JH, Marcilla A, Robbins KC (1994) Physical association between Src Homology 3 element and the protein product of the c-cbl proto-oncogene. J Biol Chem 269:17363–17366PubMedGoogle Scholar
  80. Sadowski I, Stone JC, Pawson T (1986) A noncatalytic domain conserved among cytoplasmic proteintyrosine kinases modifies the kinase function and transforming activity of fujinami sarcoma virus P130gag-fps. Mol Cell Biol 6:4396–4408PubMedGoogle Scholar
  81. Saksela K, Cheng G, Baltimore D (1995) Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for downregulation of CD4. EMBO J 14:484–491PubMedGoogle Scholar
  82. Sattler M, Salgia R, Okuda K, Uemura N, Durstin MA, Pisick E, Xu G, Li J-L, Prasad KV, Griffin JD (1996) The proto-oncogene product pl20CBL and the adaptor proteins CRKL and c-CRK link c-ABL, pl90BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3’ kinase pathway. Oncogene 12:839–846PubMedGoogle Scholar
  83. Simon MA, Dodson GS, Rubin GM (1993) An SH3-SH2-SH3 protein is required for p21Rasl activation and binds to sevenless and Sos proteins in vitro. Cell 73:169–177PubMedCrossRefGoogle Scholar
  84. Smit L, van der Horst G, Borst J (1996a) Formation of Shc/Grb2- and Crk adaptor complexes containing tyrosine phosphorylated Cbl upon stimulation of the B-cell antigen receptor. Oncogene 13:381–389PubMedGoogle Scholar
  85. Smit L, van der Horst G, Borst J (1996b) Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors. J Biol Chem 271 (15):8564–8569PubMedCrossRefGoogle Scholar
  86. Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, Neel BG, Birge RB, Fajardo JE, Chou MM, Hanafusa H, Shaffliausen B, Cantley LC (1993) SH2 domains recognize specific phosphopeptide sequences. Cell 72:767–778PubMedCrossRefGoogle Scholar
  87. Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, Ren R, Baltimore D, Ratnovsky S, Feldman RA, Cantley LC (1994) Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol 14:2777–2785PubMedGoogle Scholar
  88. Sparks AB, Rider JE, Hoffman NG, Fowlkes DM, Quilliam LA, Kay BK (1996) Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, p53 bp, PLC-y, Crk, and Grb2. Proc Natl Acad Sci USA 93.1540–1544PubMedCrossRefGoogle Scholar
  89. Sumimoto H, Kage Y, Nunoi H, Sasaki H, Nose T, Fukumaki Y, Ohno M, Minakami S, Takeshige K (1994) Role of src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase. Proc Natl Acad Sci USA 91:5345–5349PubMedCrossRefGoogle Scholar
  90. Tanaka S, Morishita T, Hashimoto Y, Hattori S, Nakamura S, Shibuya M, Matuoka K, Takenawa T, Kurata T, Nagashima K, Matsuda M (1994) C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. Proc Natl Acad Sci USA 91:3443–3447PubMedCrossRefGoogle Scholar
  91. Tang HY, Cai M (1996) The EH-domain-containing protein Panl is required for normal organization of the actin cytoskeleton in Saccharomyces cervisiae. Mol Cell Biol 16:4897–4914PubMedGoogle Scholar
  92. Teahan CG, Totty N, Casimir CM, Segal AW (1990) Purification of the 47 kDa phosphoprotein associated with the NADPH oxidase of human neutrophils. Biochem J 267:485–489PubMedGoogle Scholar
  93. Waksman G, Kominos D, Robertson SC, Pant N, Baltimore D, Birge RB, Cowburn D, Hanafusa H, Mayer BJ, Overduin M, Resh MD, Rios CB, Silverman L, Kuriyan J (1992) Crystal structure of the phosphotyrosine recognition domain (SH2) of the v-src tyrosine kinase complexed with tyrosine phosphorylated peptides. Nature 358:646–653PubMedCrossRefGoogle Scholar
  94. Wang JYJ (1993) Abl tyrosine kinase in signal transduction and cell-cycle regulation. Curr Opin Genet Dev 3:35–43PubMedCrossRefGoogle Scholar
  95. Wientjes FB, Panayotou G, Reeves E, Segal AW (1996) Interactions between cytosolic components of the NADPH oxidase: p40phox interacts with both p67phox and p47phox. Biochem J 317:919–924PubMedGoogle Scholar
  96. Yoon CH, Lee J, Jongeward GD, Sternberg PW (1995) Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl. Science 269:1102–1105PubMedCrossRefGoogle Scholar
  97. Yu H, Chen JK, Feng S, Dalgarno DC, Brauer AW, Schreiber SL (1994) Structural basis for the binding of proline-rich peptides to SH3 domains. Cell 76:933–945PubMedCrossRefGoogle Scholar
  98. Zhou M-M, Ravichandran KS, Olejniczak ET, Petros AM, Meadows RP, Harlan JE, Wade WS, Burakoff SJ, Fesik SW (1995) Structure and ligand recognition of the phosphotyrosine binding domain of She. Nature 92:7784–7788Google Scholar
  99. Zhou M-M, Huang B, Olejniczak ET, Meadows RP, Shuker SB, Miyazaki M, Trub T, Shoelson SE, Fesik SW (1996) Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain. Nature Struct Biol 3:388–393PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • B. J. Mayer
    • 1
  • R. Gupta
    • 1
  1. 1.Howard Hughes Medical Institute, Children’s Hospital and Department of Microbiology and Molecular GeneticsHarvard Medical SchoolBostonUSA

Personalised recommendations