Functions of SH2 and SH3 Domains
Cells have a remarkable ability to extract information from the extracellular environment and to respond by altering their transcriptional and replication programs, metabolism, shape, and many other aspects of their behavior. The transduction of extracellular signals is particularly crucial in multicellular organisms, where development and adult life requires that each cell precisely adjust its activities to conform to the needs of the whole organism. From an engineering standpoint the mechanisms used to transduce signals must be combinatorial in nature, because the limited number of total gene products implies that the transducers for each specific signal in each specific cell type cannot be unique. Our current understanding suggests that many types of extracellular signals are transduced by a relatively small number of enzymes including tyrosine kinases, GTP-binding proteins, and serine/threonine kinases, and that specificity of signaling arises through the assembly of multiprotein complexes involving such signaling proteins.
KeywordsPleckstrin Homology Domain Phagocyte NADPH Oxidase Activate Growth Factor Receptor Mitogenic Growth Factor Grb2 Adaptor
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