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DNA Vaccination/Genetic Vaccination pp 21–35Cite as

Vaccination Against Pathogenic Cells by DNA Inoculation

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 226))

Abstract

The goal of vaccination is to induce immunity to protect the host from disease. Vaccines should generate long-term protective immune responses which perform immune surveillance against specific antigens. Currently, a wide spectrum of vaccines are under development against not only infectious diseases, but also against cancers as well as allergic and autoimmune diseases. The mechanisms by which vaccines elicit protective immune responses against tumor growth have not been completely understood. Costimulatory molecule activation and strong cytolytic T cells (CTLs) have been implicated in the control of tumor cell growth or metastasis. Specific monoclonal antibodies have been also shown to control tumor cell growth to some degree. To achieve protective immune responses against tumor cells, we need to understand the context of the different cellular, humoral and molecular functions of the immune system.

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Authors and Affiliations

  1. Sinogen Institute, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100080, Peoples Republic of China

    B. Wang

  2. Department of Medicine, Rheumatology Division, University of Pennsylvania School of Medicine, 912 Stellar-Chance Laboratories, 422 Curie Blvd, Philadelphia, PA, 19104, USA

    A. P. Godillot, M. P. Madaio & W. V. Williams

  3. The Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 505 Stellar-Chance Laboratories, 422 Curie Blvd, Philadelphia, PA, 19104, USA

    D. B. Weiner

  4. Department of Biotechnology, Institute for Biotechnology and Advanced Molecular Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    A. P. Godillot, D. B. Weiner & W. V. Williams

  5. Childrens’ Hospital of Philadelphia, Philadelphia, PA, 19104, USA

    W. V. Williams

Authors
  1. B. Wang
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  2. A. P. Godillot
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  3. M. P. Madaio
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  4. D. B. Weiner
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  5. W. V. Williams
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Editor information

Editors and Affiliations

  1. Department of Microbiology and Immunology Center for Neurobiology, Thomas Jefferson University, Rm. M-85, Jefferson Alumni Hall 1020 Locust Street, Philadelphia, PA, 19197-6799, USA

    Hilary Koprowski M.D. (Professor) (Professor)

  2. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine Hospital of the University of Pennsylvania, 500 Stellar-Chance Bldg. 422 Curie Boulevard, Philadelphia, PA, 19104-6100, USA

    David B. Weiner Ph.D. (Associate Professor) (Associate Professor)

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© 1998 Springer-Verlag Berlin Heidelberg

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Wang, B., Godillot, A.P., Madaio, M.P., Weiner, D.B., Williams, W.V. (1998). Vaccination Against Pathogenic Cells by DNA Inoculation. In: Koprowski, H., Weiner, D.B. (eds) DNA Vaccination/Genetic Vaccination. Current Topics in Microbiology and Immunology, vol 226. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80475-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-80475-5_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80477-9

  • Online ISBN: 978-3-642-80475-5

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