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DNA Plasmid Based Vaccination Against the Oncogenic Human T Cell Leukemia Virus Type 1

  • M. G. Agadjanyan
  • B. Wang
  • S. B. Nyland
  • D. B. Weiner
  • K. E. Ugen
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 226)

Abstract

The human T cell leukemia virus type 1 (HTLV-1) holds its place in history as the first human retrovirus established to be associated with disease. Since its discovery, it has been demonstrated to be the causal agent of adult T cell leukemia (ATL) and HTLV-1 associated myelopathy (HAM). In addition, more recently this retrovirus has been suggested to have a role in the etiology and/or pathogenesis of a myriad of autoimmune disorders including rheumatoid arthritis and uveitis (Ugen et al. 1996b). Also, the role of infection with HTLV in accelerating progression to acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-1 infected individuals has also been suggested (Kramer et al. 1989). The worldwide seropositivity of HTLV-1 and the related HTLV-2 is estimated to be at least 10 million. Coupled with its association to fatal and debilitating disorders as well as its potential role in the pathogenesis of other serious illnesses an effective vaccine is warranted. In this review we will summarize current information on HTLV-1 including immune responses to this virus, correlates of protection as well as potential vaccination strategies including DNA plasmid inoculation.

Keywords

Leukemia Virus Acquire Immune Deficiency Syndrome Bovine Leukemia Virus Cell Leukemia Virus Type Inhibit Syncytium Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • M. G. Agadjanyan
    • 1
    • 2
  • B. Wang
    • 3
  • S. B. Nyland
    • 4
  • D. B. Weiner
    • 1
  • K. E. Ugen
    • 4
  1. 1.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Institute of Viral PreparationsRussian Academy of Medical ScienceMoscowRussia
  3. 3.Sinogen Institute, Institute of ZoologyChinese Academy of SciencesBeijingChina
  4. 4.Department of Medical Microbiology and ImmunologyUniversity of South Florida College of MedicineTampaUSA

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