Developing DNA Vaccines Against Immunodeficiency Viruses
More than a decade after the identification of human immunodeficiency virus-1 (HIV-1) as the causative pathogen of AIDS, the prospects for an HIV-1 vaccine in the foreseeable future are still low. Attempts using conventional vaccine approaches have not met with much success (for recent reviews see Haynes 1993; Bolognesi 1993, 1995). The live attenuated vaccine approach appeared promising when its effectiveness was demonstrated in a simian immunodeficiency virus (SIV) model in macaques (Daniel et al. 1994, 1992). However, additional studies in neonatal macaques raised safety concerns regarding this approach (Baba et al. 1995). The search for novel vaccine strategies that target the unique biological features of HIV-1 remains a challenging yet important task.
KeywordsHepatitis Attenuation Influenza Germinal Malaria
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