Developing DNA Vaccines Against Immunodeficiency Viruses

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 226)


More than a decade after the identification of human immunodeficiency virus-1 (HIV-1) as the causative pathogen of AIDS, the prospects for an HIV-1 vaccine in the foreseeable future are still low. Attempts using conventional vaccine approaches have not met with much success (for recent reviews see Haynes 1993; Bolognesi 1993, 1995). The live attenuated vaccine approach appeared promising when its effectiveness was demonstrated in a simian immunodeficiency virus (SIV) model in macaques (Daniel et al. 1994, 1992). However, additional studies in neonatal macaques raised safety concerns regarding this approach (Baba et al. 1995). The search for novel vaccine strategies that target the unique biological features of HIV-1 remains a challenging yet important task.


Human Immunodeficiency Virus Type Simian Immunodeficiency Virus Simian Immunodeficiency Virus Infection Human Immunodeficiency Virus Vaccine Control Macaque 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • S. Lu
    • 1
  1. 1.Department of MedicineUniversity of Massachusetts Medical CenterWorcesterUSA

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