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Developing DNA Vaccines Against Immunodeficiency Viruses

  • Chapter
DNA Vaccination/Genetic Vaccination

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 226))

Abstract

More than a decade after the identification of human immunodeficiency virus-1 (HIV-1) as the causative pathogen of AIDS, the prospects for an HIV-1 vaccine in the foreseeable future are still low. Attempts using conventional vaccine approaches have not met with much success (for recent reviews see Haynes 1993; Bolognesi 1993, 1995). The live attenuated vaccine approach appeared promising when its effectiveness was demonstrated in a simian immunodeficiency virus (SIV) model in macaques (Daniel et al. 1994, 1992). However, additional studies in neonatal macaques raised safety concerns regarding this approach (Baba et al. 1995). The search for novel vaccine strategies that target the unique biological features of HIV-1 remains a challenging yet important task.

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Authors and Affiliations

  1. Department of Medicine, University of Massachusetts Medical Center, Worcester, MA, 01655, USA

    S. Lu

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  1. S. Lu
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Editors and Affiliations

  1. Department of Microbiology and Immunology Center for Neurobiology, Thomas Jefferson University, Rm. M-85, Jefferson Alumni Hall 1020 Locust Street, Philadelphia, PA, 19197-6799, USA

    Hilary Koprowski M.D. (Professor) (Professor)

  2. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine Hospital of the University of Pennsylvania, 500 Stellar-Chance Bldg. 422 Curie Boulevard, Philadelphia, PA, 19104-6100, USA

    David B. Weiner Ph.D. (Associate Professor) (Associate Professor)

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© 1998 Springer-Verlag Berlin Heidelberg

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Lu, S. (1998). Developing DNA Vaccines Against Immunodeficiency Viruses. In: Koprowski, H., Weiner, D.B. (eds) DNA Vaccination/Genetic Vaccination. Current Topics in Microbiology and Immunology, vol 226. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80475-5_10

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  • DOI: https://doi.org/10.1007/978-3-642-80475-5_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80477-9

  • Online ISBN: 978-3-642-80475-5

  • eBook Packages: Springer Book Archive

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