Skip to main content
SpringerLink
Log in

Strategies for Preventive and Therapeutic Vaccination Against Helicobacter pylori Infection

  • Conference paper
Symposium in Immunology VII

  • 48 Accesses

Abstract

Infection of the gastroduodenal mucosa by the gram-negative organism Helicobacter pylori is associated with the occurrence of chronic active gastritis and peptic ulcer, and also increases the risk of gastric cancer (Parsonnet et al. 1991, 1994; Blaser and Parsonnet 1994). The risk of infection is high in childhood and is directly correlated to low hygienic conditions and overcrowded environments (Webb et al. 1994). Once established, a successful colonization may be lifelong. Due to significant improvement in hygienic conditions the risk of exposure to infection is now decreasing in the developed countries, where the prevalence of infection approximately increases 1% per year of age and is about 40%–50% in the over-50-year-old population. However, in developing countries as much as 80% of the young population can be infected before adolescence, and nearly all elderly individuals are infected (Megraud 1994).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Blaser MJ, Parsonnet J (1994) Parasitism by the ‘slow’ bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest 94:4–8

    Article  PubMed  CAS  Google Scholar 

  • Blaser MJ, Chyou PH, Nomura A (1995) Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. Cancer Res 55:562–565

    PubMed  CAS  Google Scholar 

  • Cellini L, Allocati N, Angelucci D, Iezzi T, DiCampli E, Marzio L, Dainelli B (1994) Coccoid Helicobacter pylori not culturable in vitro reverts in mice. Microbiol Immunol 38:843–850

    PubMed  CAS  Google Scholar 

  • Censini S, Lange N, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, Rappuoli R, Covacci A (1996) cag, a pathogenicity island of Helicobacter pylori, encodes type I- specific and disease associated virulence factors. Proc Natl Acad Sei USA 93:14648–14653

    Article  CAS  Google Scholar 

  • Chen M, Lee A, Hazell S (1992) Immunisation against gastricHelicobacter infection in a mous el Helicobacter felis model. Lancet 339:1120–1121

    Article  PubMed  CAS  Google Scholar 

  • Corthesy-Theulaz I, Porta N, Glauser M, Saraga E, Vaney AC, Haas R, Kraehenbuhl JP, Blum AL, Michetti P (1995) Oral immunization with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice. Gastroenterology 109:115–121

    Article  PubMed  CAS  Google Scholar 

  • Covacci A, Censini S, Bugnoli M, Petracca R, Burroni D, Macchia G, Massone A, Papini E, Xiang Z, Figura N, Rappuoli R (1993) Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sei USA 90:5791–5795

    Article  CAS  Google Scholar 

  • Crabtree JE, Shallcross TM, Wyatt JI, Taylor JD, Heatley RV, Rathbone BJ, Losowsky MS (1991a) Mucosal humoral immune response to Helicobacter pylori in patients with duodenitis. Dig Dis Sei 36:1266–1273

    Article  CAS  Google Scholar 

  • Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI (1991b) Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 32:1473–1477

    Article  PubMed  CAS  Google Scholar 

  • Crabtree JE, Peichl P, Wyatt JI, Stachl U, Lindley IJ (1993) Gastric interleukin-8 and IgA IL-8 autoantibodies in Helicobacter pylori infection. Scand J Immunol 37:65–70

    Article  PubMed  CAS  Google Scholar 

  • Crabtree JE, Covacci A, Farmery SM, Xiang Z, Tompkins DS, Perry S, Lindley IJD, Rappuoli R (1995) Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype. J Clin Pathol 48:41–45

    Article  PubMed  CAS  Google Scholar 

  • D’Elios M, Manghetti M, De Carli M, Costa F, Baldari CT, Burroni D, Telford JL, Romagnani S, Del Prete G (1997) Thi effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer. J Immunol 158 962–967

    PubMed  Google Scholar 

  • Di Tommaso A, Xiang Z, Bugnoli M, Pileri P, Figura N, Bayeli PF, Rappuoli R, Abrignani S, De Magistris MT (1995) Helicobacter pylori-specific CD4+ T-cell clones from peripheral blood and gastric biopsies. Infect Immun 63:1102–1106

    PubMed  Google Scholar 

  • Di Tommaso A, Saletti G, Pizza M, Rappuoli R, Dougan G, Abrignani S, Douce G, De Magistris MT (1996) Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant. Infect Immun 64:974–979

    PubMed  Google Scholar 

  • Doidge C, Gust I, Lee A, Buck F, Hazell S, Manne U (1994) Therapeutic immunization against Helicobacter infection. Lancet 343:914–915

    Article  PubMed  CAS  Google Scholar 

  • Douce G, Trucotte C, Cropley I, Roberts M, Pizza M, Domenighini M, Rappuoli R, Dougan G (1995) Mutants ofEscherichia coli heat-labile toxin lacking ADP-ribo-syltransferase activity act as nontoxic, mucosal adjuvants. Proc Natl Acad Sei USA 92:1644–1648

    Article  CAS  Google Scholar 

  • Hansson LE, Nyren O, Hsing AW, Bergstrom R, Josefsson S, Chow WH, Fraumeni JF, Adami HO (1996) The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med 335:242–249

    Article  PubMed  CAS  Google Scholar 

  • Karita M, Kouchiyama T, Okita K, Nakazawa T (1991) New small animal model for human gastricHelicobacter pylori infection: success in both nude and euthymic mice. Am J Gastroenterol 86:1596–1603

    PubMed  CAS  Google Scholar 

  • Kreiss C, Buclin T, Cosma M, Corthesy-Theulaz I, Michetti P (1996) Safety of oral immunisation with recombinant urease in patients with Helicobacter pylori infection. Lancet 347:1630–1631

    Article  PubMed  CAS  Google Scholar 

  • Lee CK, Weltzin R, Thomas WD, Kleanthous H, Ermak TH, Soman G, Hill JE, Ackerman SK, Monath TP (1995) Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis. J Infect Dis 172:161–172

    Article  PubMed  CAS  Google Scholar 

  • Lycke N, Tsuji T, Holmgren J (1992) The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity. Eur J Immunol 22:2277–2281

    Article  PubMed  CAS  Google Scholar 

  • Malfertheiner P (1993) Compliance, adverse events and antibiotic resistance in Helicobacter pylori treatment. Scand J Gastroenterol Suppl 196:34–37

    Article  PubMed  CAS  Google Scholar 

  • Manetti R, Massari P, Burroni D, DeBernard M, Marchini A, Olivieri R, Papini E, Montecucco C, Rappuoli R, Telford IL (1995)Helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies. Infect Immun 63:4476–4480

    PubMed  CAS  Google Scholar 

  • Marchetti M, Arico B, Burroni D, Figura N, Rappuoli R, Ghiara P (1995) Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science 267:1655–165

    Article  PubMed  CAS  Google Scholar 

  • Marshall BJ (1988) TheCampylobacter pylori story. Scand J Gastroenterol Suppl 146:58–66

    Article  PubMed  CAS  Google Scholar 

  • Megraud F (1994) Epidemiology of Helicobacter pylori infection: where are we in 1995? Eur J Gastroenterol Hepatol 7:292–295

    Google Scholar 

  • Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK (1991)Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 325:1127–1231

    Article  PubMed  CAS  Google Scholar 

  • Parsonnet J, Hansen S, Rodriguez L, Gelb AB, Warnke RA, Jellum E, Orentreich N, Vogelman HJ, Friedman GD (1994) Helicobacter pylori infection and gastric lymphoma. N Engl J Med 330:1267–1271

    Article  PubMed  CAS  Google Scholar 

  • Pizza M, Fontana MR, Giuliani MM, Domenighini M, Magagnoli C, Giannelli V, Nucci D, Hoi W, Manetti R, Rappuoli R (1994) A genetically detoxified derivative of heat-labileEscherichia coli enterotoxin induces neutralizing antibodies against the A subunit. J Exp Med 80:2147–2153

    Article  Google Scholar 

  • Rautelin H, Tee W, Seppala K, Kosunen TU (1994) Ribotyping patterns and emergence of metronidazole resistance in paired clinical samples of Helicobacter pylori. J Clin Microbiol 32:1079–1082

    CAS  Google Scholar 

  • Sharma SA, Miller GG, Perez-Perez GI, Gupta RS, Blaser MJ (1994) Humoral and cellular immune recognition of Helicobacter pylori proteins are not concordant. Clin Exp Immunol 97:126–132

    Article  PubMed  CAS  Google Scholar 

  • Shea JE, Hensel M, Gleeson C, Holden DW (1996) Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium. Proc Natl Acad Sci USA 95:2593–2597

    Article  Google Scholar 

  • Telford JL, Covacci A, Ghiara P, Montecucco C, Rappuoli R (1994) Unravelling the pathogenic role of Helicobacter pylori in peptic ulcer: potential for new therapies and vaccines. Trends Biotechnol 12:420–426

    Article  PubMed  CAS  Google Scholar 

  • Tytgat GNJ (1994) Treatments that impact favourably upon the eradication of Helicobacter pylori and ulcer recurrence. Aliment Pharmacol Ther 8:359–368

    Article  PubMed  CAS  Google Scholar 

  • Webb PM, Knight T, Greaves S, Wilson A, Newell DG, Elder J, Forman D (1994) Relation between infection with Helicobacter pylori and living conditions in childhood — evidence for person to person transmission in early life. Br Med J 308:750—753

    Google Scholar 

  • Xiang Z, Bugnoli M, Ponzetto A, Morgando A, Figura N, Covacci A, Petracca R, Pennatini C, Censini S, Armellini D, Rappuoli R (1993) Detection in an enzyme immunoassay of an immune response to a recombinant fragment of the 128 kilodalton protein (CagA) of Helicobacter pylori. Eur J Clin Microbiol Infect Dis 12:739–745

    Article  PubMed  CAS  Google Scholar 

  • Xiang ZY, Censini S, Bayeli PF, Telford JL, Figura N, Rappuoli R, Covacci A (1995) Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin. Infect Immun 63:9498

    Google Scholar 

Download references

Authors
  1. P. Ghiara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Marchetti
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Immunologie der Universität Wien, Borschkegasse 8 a, 1090, Wien, Austria

    Martha M. Eibl

  2. Abteilung Hämatologie, Johannes Gutenberg Universität, Langenbeckstr. 1, 55101, Mainz, Germany

    Christoph Huber

  3. Abteilung für Rheumatologie und Klinische Immunologie, Medizinische Universitätsklinik, Hugstetter Str. 55, 79106, Freiburg, Germany

    Hans H. Peter

  4. Pädiatrische Pneumologie und Immunologie, Universitäts-Klinikum Rudolf-Virchow Standort Charlottenburg, Heubnerweg 6, 14059, Berlin, Germany

    Ulrich Wahn

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Ghiara, P., Marchetti, M. (1998). Strategies for Preventive and Therapeutic Vaccination Against Helicobacter pylori Infection. In: Eibl, M.M., Huber, C., Peter, H.H., Wahn, U. (eds) Symposium in Immunology VII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80466-3_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80466-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-63360-0

  • Online ISBN: 978-3-642-80466-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation