Small effects as a main problem in epidemiology
The current development of modern epidemiology has been strongly influenced by the changing patterns of diseases in the western world, namely away from infectious diseases and towards chronic diseases caused by civilization. The famous epidemiological studies, having shown the overwhelming effects of smoking on lung cancer or alcohol consumption in respect to cirrhosis of the liver, as well as having illustrated the concept of cardiovascular risk factors, created the following myth of the sixties and seventies:
Assuming a proper study design and good epidemiological practice, it was hypothesised that there would be a possibility to detect the main causes and prerequisites for every chronic disease.
KeywordsCholesterol Chole Dioxin Marin
Unable to display preview. Download preview PDF.
- 5.Salvaggior A, Periti M, Miano L, Onaglia G, Narzorati D (1991) Coffee and cholesterol, an Italian study. Am J Epidemiol 134: 149–156Google Scholar
- 6.Pietinen P, Geboers J, Kesteloot H (1988) Coffee consumption and serum cholesterol. An epidemiolgical study in Belgium. Int J Epidemiol 17: 98–104Google Scholar
- 8.Nicols AB, Ravenscroft C, Lamphierer DE, Ostrander (1976) Independence of serum lipid levels and dietary habits. The Tromsek study. J Am Med Assoc 236: 1948–1953Google Scholar
- 13.Savitz DA, Greenland S, Stolley PD, Kelsey JL (1990) Scientific standards of criticism: a reaction to “Scientific standards in epidemiologic studies of the menace of daily life” by A.R. Feinstein. Epidemiology 1: 78–83Google Scholar
- 14.Anonymous (1995) Sizing up the cancer risks. Science 269: 165Google Scholar