Zusammenfassung
Neben der allgemeinen, akut oder subchronisch auftretenden Toxizität auf gesundes, rasch proliferierendes Gewebe treten im Rahmen konventionell- und hochdosierter Chemotherapien — abhängig vom eingesetzten Zytostatikum — auch eine Reihe organspezifischer Toxizitäten auf. Diese lassen sich weniger durch die antiproliferative Aktivität, sondern vielmehr durch andere Eigenschaften des Zytostatikums wie der Entstehung bestimmter toxischer Metabolite oder durch relativ hohe Anreicherungen in einzelnen Organen erklären.
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Weiss, B., Lipp, HP., Hartmann, J.T., Bokemeyer, C., Sökler, M. (1998). Prophylaxe und Behandlung spezieller Nebenwirkungen von Zytostatika. In: Bokemeyer, C., Lipp, HP. (eds) Praktische Aspekte der supportiven Therapie in Hämatologie und Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80459-5_8
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DOI: https://doi.org/10.1007/978-3-642-80459-5_8
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