Molecular Pathogenesis of Urinary Tract Infections

  • S. E. F. D’Orazio
  • C. M. Collins
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 225)


Urinary tract infection (UTI) is the most common bacterial infection of the human body. It has been estimated that there are as many as 8 million visits a year to physicians’ offices for treatment of the symptoms of UTI and more than 100 000 hospital admissions for serious infections (US Department of Health and Human Services 1990). In addition, the urinary tract is usually the most common source of bacteremia in hospitals and nursing homes. The presence of bacteria in urine (bacteriuria) alone is not necessarily indicative of a UTI; significant bacterial counts (> 105 cfu/ml) and pyuria are the classic signs of UTI. Infections can range from mild, asymptomatic episodes of bladder infection (cystitis) to more severe, life-threatening complications of the kidney, such as acute pyelonephritis.


Urinary Tract Infection Proteus Mirabilis Acute Pyelonephritis Uroepithelial Cell Wildtype Strain 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • S. E. F. D’Orazio
    • 1
  • C. M. Collins
    • 2
  1. 1.Department of Microbiology and Molecular GeneticsHarvard Medical SchoolBostonUSA
  2. 2.Department of Microbiology and ImmunologyUniversity of Miami School of MedicineMiamiUSA

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