Mechanisms of Pathogenesis of Staphylococcal and Streptococcal Superantigens
In order to infect a host successfully, to access nutrients, and to promote the progression of disease, many pathogenic bacteria, such as the staphylococci and streptococci, produce exoproteins which enhance microbial virulence. Among these proteins is the family of toxins known today as the superantigens (SAg). This family includes the pyrogenic toxin SAg (PTSAg), such as the staphylococcal enterotoxins (SE, serotypes A-E, G, H), group A streptococcal pyrogenic exotoxins (SPE, serotypes A-C and possibly F), streptococcal SAg (SSA), and staphylococcal toxic shock syndrome toxin (TSST)-1. The following is a review of the biochemistry, structure, and mechanisms of pathogenicity of the PTSAg and the shared and unique properties of each. The properties of other relevant superantigenic proteins such as the staphylococcal exfoliative toxins (ETA, ETB) will also be discussed.
KeywordsArthritis Histidine Peritonitis Pier Staphylococcus
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- Bergdoll MS, Schlievert P (1984) Toxic-shock syndrome toxin. Lancet ii:691Google Scholar
- Fast DJ, Schlievert PM, Nelson RD (1989) Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production. Infect Immun 57:292–294Google Scholar
- Hauser AR, Vath GM, Ohlendorf DH, Schlievert PM (1995) In: Thibodeau J, Sekaly R (eds) Bacterial superantigens: structure, function and therapeutic potential. Structural studies of streptococcal pyrogenic exotoxin superantigens. Landes, Austin, pp 39–48Google Scholar
- Herman A, Kappler J, Marrack P, Pullen A (1991) Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu Rev Microbiol 9:745–772Google Scholar
- Shands K, Schmid GP, Dan BB, Blum D, Guidotti RJ, Hargrett NT, Anderson RL, Hill DL, Broome CV, Band JD, Fraser DW (1980) Toxic shock syndrome in menstruating women: its association with tampon use and Staphylococcus aureus and the clinical features in 52 cases. N Engl J Med 303:1436–1442PubMedCrossRefGoogle Scholar
- Spero L, Metzger JF, Warren JR, Griffin BA (1975) Biological activity and complementation of two peptides of staphylococcal enterotoxin B formed by limited tryptic hydrolysis. J Biol Chem 250:5026Google Scholar
- Wagner JG, Schlievert PM, Assimacoupoulos AP, Stoehr JA, Carlson PJ, Komadina K (1997) Acute group G streptococcal myositis with toxic shock like syndrome. Clin Infect Dis (in press)Google Scholar