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The Pysiology of Bone Turnover

  • R. Pacifici

Abstract

Bone is remodeled by a sequence of cellular events which occur in discrete locations known as bone remodeling units. This process begins with the activation of mature osteoclasts adhering to the bone surfaces usually covered by lining osteoblasts and with an expansion of the osteoclastic pool. Through the interaction of preexisting and newly formed osteoclasts with osteoblasts, resorption is initiated in discrete areas. This phase, which lasts 2–4 weeks, leads to the formation of focal areas of bone resorption which reach a depth of about 30 μm [1]. Toward the end of the resorption phase mononuclear cells, an important source of cytokines, are typically found at the bottom of the resorption cavity [1]. The transition from resorption to formation is called reversal. This phase is characterized by the accumulation of osteoblast precursors and of a thin layer of inorganic matrix, known as cement line, at the bottom of the resorption pit. The cement line is rich in osteopontin, a RGD-rich protein which may be involved in signaling the cessation of osteoclastic activity. This is followed by the replacement of the removed bone by osteoblasts which accumulate at the base of the resorption lacunae and subsequently fill in the resorption cavity with newly formed bone.

Keywords

Bone Loss Bone Resorption Stromal Cell Bone Turnover Osteoclast Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • R. Pacifici

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