Cellular Models for In Vitro Toxicity Testing

  • Flavia Zucco
  • Isabella De Angelis
  • Annalaura Stammati
Part of the Springer Lab Manual book series (SLM)


Compared to other biomedical disciplines, cell culture systems have only recently been systematically adopted for use in toxicology (Paganuzzi Stammati et al. 1981), due, in particular, to the difficulty in extrapolating in vitro data to the in vivo situation for regulatory purposes. However, in the last decade, technological advancements using cell culture systems, together with the important results obtained in biomedical research, have impressively promoted its use in toxicology investigations. Growth factors and substrates able to stimulate cell proliferation and/or expression of specific highly specialized functions, and sophisticated analytical techniques for mechanistic studies, together with automated procedures, have played a pivotal role.


Cellular Model Continuous Cell Line Gentian Violet Respiration Buffer Vitro Toxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Flavia Zucco
    • 1
  • Isabella De Angelis
    • 2
  • Annalaura Stammati
    • 2
  1. 1.Istituto Tecnologie BiomedicheC.N.RRomeItaly
  2. 2.Laboratorio di Tossicologia Comparata ed EcotossicologiaIstituto Superiore di SanitàRomeItaly

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