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Das koronare Gefäßendothel

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Herzerkrankungen und Interventions-möglichkeiten

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Zusammenfassung

Die Koronarzirkulation wird von verschiedenen Systemen beeinflußt, deren Gleichgewicht unter pathophysiologischen Bedingungen gestört sein kann. Hierzu gehören das sympathische Nervensystem, zirkulierende Hormone und lokale, am Gefäß agierende Faktoren. Die entscheidende Bedeutung der lokalen Regulationsmechanismen von Gefäßendothel und glatten Gefäßmuskelzellen wurde erst in den letzten Jahren erkannt. Durch seine strategisch wichtige Lage zwischen Blut(produkten) und der glatten Gefäßmuskelzellschicht spielt das Gefäßendothel eine zentrale Rolle bei der Modulierung von Gefäßtonus und -wachstum sowie bei der Abwehr potentiell schädlicher Einflüsse. Damit ist das Gefäßendothel aber auch besonders stark diesen Einflüssen, wie z.B. Lipoproteinen und mechanischen Stimuli („Stretch“) ausgesetzt. Eine wichtige Rolle spielt das Endothel bei der Modulation des Gefäßtonus, der Thrombozytenaggregation, der Gerinnung und der Monozytenadhäsion.

Die in diesem Beitrag beschriebenen Originaluntersuchungen der Autoren wurden vom Schweizerischen Nationalfonds (32-32541.91, 32-32655.91), SCORE (32-35591.92) und durch ein Stipendium der Deutschen Forschungsgemeinschaft (René R. Wenzel, We 1772/1-1) unter-stützt. Die Autoren danken Amanda de Sola Pinto für die ausgezeichnete Mithilfe bei der Erstellung des Manuskripts.

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  1. R. R. Wenzel
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  1. Müllner Hauptstraße 48, A-5020, Salzburg, Österreich

    Felix Unger FESC, FACC (Vorstand der Herzchirurgie Salzburg, Direktor) (Vorstand der Herzchirurgie Salzburg, Direktor)

  2. European Heart Institute, Europäischen Akademie der Wissenschaften und Künste, Waagplatz 3, A-5020, Salzburg, Österreich

    Felix Unger FESC, FACC (Vorstand der Herzchirurgie Salzburg, Direktor) (Vorstand der Herzchirurgie Salzburg, Direktor)

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Wenzel, R.R., Noll, G., Lüscher, T.F. (1998). Das koronare Gefäßendothel. In: Unger, F. (eds) Herzerkrankungen und Interventions-möglichkeiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80404-5_7

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