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The Role of Apolipoprotein (a) in Childhood Thromboembolism

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27. Hämophilie-Symposion Hamburg 1996

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Abstract

Elevated lipoprotein (a) concentrations are independent risk factors of coronary heart disease or stroke in young adults. To claify its role in childhood thrombosis, Lp (a) was measured in a population with arterial or venous thrombosis. Increased Lp (a) was diagnosed in eight of 36 children with arterial and five out of 36 children with venous thrombosis. Data of this study indicate that increased Lp (a) concentrations play an important role in childhood thrombosis.

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References

  1. Armstrong VW, Walli AK, Seidel D (1985) Isolation, characterization and uptake in human fibroblasts of an apo (a)-free lipoprotein obtained on reduction of lipoprotein (a). J Lipid Res 26: 1314–1323

    PubMed  CAS  Google Scholar 

  2. Seman LJ, Breckenridge WC (1986) Isolation an partial characterisation of apolipoprotein (a) from human lipoprotein (a). Biochem Cell Biol 64: 999–1009

    Article  PubMed  CAS  Google Scholar 

  3. Zenker G, Költringer P, Bone G, Niederkorn K, Pfeiffer K, Jürgens G (1986) Lipoprotein (a) as a strong indicator for cerebrovascular disease. Stroke 17: 942–945

    Article  PubMed  CAS  Google Scholar 

  4. Albers JJ, Hazzard WR (1974) Immunochemical quantification of human plasma Lp (a) lipoprotein. Lipids 9: 15–26

    Article  PubMed  CAS  Google Scholar 

  5. Berg K, Dahlen G, Frick MH (1974) Lp (a) lipoprotein and pre-beta 1 lipoprotein in patients with coronary heart disease. Clin Genet 6: 230–235

    Article  PubMed  CAS  Google Scholar 

  6. Seed M, Hoppichler F, Reaveley D, McCarthy S, Thomson GR, Boerwinkle E, Uterman G (1990) Relation of serum lipoprotein (a) concentration and apolipoprotein (a) phenotype to coronary heart disease in patients with familial hypercholesterolemia. N Engl J Med 322: 1494–1499

    Article  PubMed  CAS  Google Scholar 

  7. Sandkamp M, Funke H, Schulte H, Köhler E, Assmann G (1990) Lipoprotein (a) is an independent risk factor for myocardial infarction at a young age. Clin Chem 36: 20–23

    PubMed  CAS  Google Scholar 

  8. Murai A, Miyahara T, Fujimoto N, Matsuda M, Kameyama M (1986) Lp (a) lipoprotein as a risk factor for coronary heart disease and cerebral infarction.Atherosclerosis 59: 199–204

    CAS  Google Scholar 

  9. Nagayama M, Shinohara Y, Nagayama T (1994) Lipoprotein (a) and ischemic cerebrovascular disease in young adults. Stroke 25: 74–78

    Article  PubMed  CAS  Google Scholar 

  10. Jürgens G, Költringer P (1994) Cerebrovascular disease and Lp (a): its role in atherosclerotic plaque formation and vessel wall elasticity of the carotid arteries. Chem Phys Lipids 68: 429–434

    Article  Google Scholar 

  11. Woo J, Lau E, Lamm CWK et al (1991) Hypertension, lipoprotein (a), and apolipoprotein A-I as risk factors for stroke in the Chinese. Stroke 22: 203–208

    Article  PubMed  CAS  Google Scholar 

  12. Margaglione M, Di Minno G, Grandone E et al (1996) Plasma lipoprotein (a) levels in subjects attending a metabolic ward. Arterioscier Thromb Vasc Biol 16: 120–128

    Article  CAS  Google Scholar 

  13. Hoff HF, Beck GJ, Skibinski CI, Jürgens G, O’Neil J, Kramer J, Lytle B (1988) Serum Lp (a) levels as a predictor of vein graft stenosis after coronary artery bypass surgery in patients. Circulation 77: 1238–1244

    Article  PubMed  CAS  Google Scholar 

  14. Rath M, Niendorf A, Reblin T, Dietel M, Krebber HJ, Beisiegel U (1989) Detection and quantification of lipoprotein (a) in the arterial: wall of 107 coronary by-pass patients. Arteriosclerosis 9: 579–592

    Article  PubMed  CAS  Google Scholar 

  15. Andrew M, Paes B, Milner R, Johnston M (1990)Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol 12: 95–104

    Google Scholar 

  16. Andrew M, Vegh P, Johnston M, Bowker J, Ofosu F, Mitchell L (1992) Maturation of the hemostatic system during childhood. Blood 80: 1998–2005

    PubMed  CAS  Google Scholar 

  17. Nowak-Göttl U, Funk M, Mosch G, Wegerich B, Kornhuber B, Breddin HK (1994) Univariatetolerance regions for fibrinogen, antithrombin III, protein C, protein S, plasmi- nogen and a2-antiplasmin in children using the new automated coagulation laboratory (ACL) method. Klin Pädiatr 206: 437–439

    Google Scholar 

  18. Nowak-Göttl U, Koch HG, Aschka I et al (1996) Resistance to activated protein C ( APCR) in children with venous or arterial thromboembolism. Br J Haematol 92: 992–998

    Google Scholar 

  19. Berg K (1963) A new serum type system in man–the Lp system. Acta Pathol Microbiol Scand 59: 369–383

    Article  PubMed  CAS  Google Scholar 

  20. McLean JW, Tomlinson JE, Kuang WJ (1987) cDNA sequence of human apolipoprotein (a) is homologous to plasminogen. Nature 300: 132–137

    Google Scholar 

  21. Miles LA, Fless GM, Levin EG, Scanu AM, Plow EF (1989) A potential basis for the thrombotic risk associated with lipoprotein (a). Nature 339: 301–303

    Article  PubMed  CAS  Google Scholar 

  22. Utermann G (1989) The mysteries of lipoprotein (a). Science 246: 904–910

    Article  PubMed  CAS  Google Scholar 

  23. Cambillau M, Simon A, Amar J et al (1992) Serum Lp (a) as a discriminant marker of early atherosclerotic plaques at three extracoronary sites in hypercholestrolemic men. Arterioscl Throm 12: 1346–1352

    Article  CAS  Google Scholar 

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Authors
  1. M. Findeisen
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  2. H. Vielhaber
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  3. O. Debus
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  4. G. Kurlemann
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  5. U. Nowak-Göttl
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Editor information

Editors and Affiliations

  1. Zentr. d. Inn. Med., Med. Klinik I, Universitätsklinikum, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Deutschland

    Inge Scharrer

  2. Hämostaseologische Abteilung, Med. Univ.-Klinik Innenstadt, Ziemssenstraße 1a, D-80336, München, Deutschland

    Wolfgang Schramm

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© 1998 Springer-Verlag Berlin Heidelberg

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Findeisen, M., Vielhaber, H., Debus, O., Kurlemann, G., Nowak-Göttl, U. (1998). The Role of Apolipoprotein (a) in Childhood Thromboembolism. In: Scharrer, I., Schramm, W. (eds) 27. Hämophilie-Symposion Hamburg 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80403-8_74

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  • DOI: https://doi.org/10.1007/978-3-642-80403-8_74

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-62915-3

  • Online ISBN: 978-3-642-80403-8

  • eBook Packages: Springer Book Archive

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