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T-PA, u-PA and PAI 1 Concentrations before, during and 24 Hours after Percutaneous Cardiac Catheterisation

  • E. Hagemeyer
  • H. Vielhaber
  • D. Kececioglu
  • H. G. Kehl
  • U. Nowak-Göttl
Conference paper

Abstract

To find out to what extent diagnostic cardiac percutaneous catheterisation irritates vascular endothelium in 140 children before, immediately at the end of, and 24 hours after catheterisation, t-PA, u-PA and PAI 1 were investigated. Compared to starting values, t-PA, u-PA and PAI 1 concentrations showed a significant increase at the end of catheterisation. u-PA and PAI 1 returned to pretreatment values 24 h later, t-PA remained elevated. Four out of seven children with thrombosis showed increased t-PA antigen and/or PAI 1 antigen activities before cardiac catheterisation was performed. Data of this study indicate that increased t-PA, u-PA and PAI 1 antigen levels are signs of endothelial damage. Whether increased values of t-PA or PAI 1 may predict future vascular occlusion in infants undergoing cardiac catheterisation requires a more extensive study.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • E. Hagemeyer
  • H. Vielhaber
  • D. Kececioglu
  • H. G. Kehl
  • U. Nowak-Göttl

There are no affiliations available

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