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Erworbene v.-Willebrand-Krankheit: Behandlung bei Blutungen und bei operativen Eingriffen

  • E. Lechler
Conference paper

Zusammenfassung

Eine erworbene v.-Willebrand-Krankheit kann spontan oder im Zusammenhang mit benignen monoklonalen Gammopathien [4, 6, 8, 10, 11, 15, 17], lymphoproliferativen Erkrankungen [10, 11, 15], Plasmozytom [2, 7, 12], soliden Tumoren [9] oder autoimmunologischen Erkrankungen wie Lupus erythematodes etc. [11, 16], Medikamenten [5,13] wie auch bei myeloproliferativen Erkrankungen [3], hypothyreoten und hyperfibrinolytischen [8] Zuständen auftreten.

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Literatur

  1. 1.
    Ball J, Malia RG, Preston FE (1987) Demonstration of abnormal factor VIII multimers in acquired von Willebrand’s disease associated with a circulating inhibitor. Br J Haematol 65: 95–100PubMedCrossRefGoogle Scholar
  2. 2.
    Bovill EG, Ershler, WB, Golden EA, Tindle BH, Edson JR (1986) A human myeloma-produced monoclonal protein directed against the active subpopulation of von Willebrand factor. Am J Clin Pathol 85: 115–123PubMedGoogle Scholar
  3. 3.
    Budde U, Dent JA, Berkowitz SC, Ruggeri ZM, Zimmermann TS (1986) Subunit composition of plasma von Willebrand factor in patients with the myeloproliferative syndrome. Blood 68: 1213–1217PubMedGoogle Scholar
  4. 4.
    Castaman G, Tosetto A, Rodeghiero F (1992) Effektiveness of high-dose intravenous immunglobulin in a case of acquired von Willebrand syndrome with chronic melena not responsive to desmopressin and factor VIII concentrate. Am J Hematol 41: 132–136PubMedCrossRefGoogle Scholar
  5. 5.
    Conrad ME, Latour LF (1992) Acquired von Willebrand’s disease, IgE polyclonal gammopathy and griseofulvin therapy. Am J Hematol 41: 143Google Scholar
  6. 6.
    Delannoy A, Saillez AC (1988) High-dose intravenous gammglobulin for acquired von Willebrand’s disease. Br J Haematol 70: 387PubMedCrossRefGoogle Scholar
  7. 7.
    Drouin J, Lillicrap DP, Izaguirre CA, Sutherland M, Windsor S, Benford K, Hoggendorn H, Giles AR (1989) Absence of bleeding tendency in severe acquired von Willebrand’s disease. Am J Clin Pathol 92: 471–478PubMedGoogle Scholar
  8. 8.
    Eikenboom JCJ, van der Meer FJM, Briet E (1992) Acquired von Willebrand’s disease due to excessive fibrinolysis. Br J Haematol 81: 618–620PubMedCrossRefGoogle Scholar
  9. 9.
    Facon T, Caron C, Courtin P, Wurtz A, Deghaye M, Bauters F, Mazurier C, Goudemand J (1992) Acquired type II von Willebrand’s disease associated with adrenal cortical carcinoma. Br J Haematol 80: 488–494PubMedCrossRefGoogle Scholar
  10. 10.
    van Genderen PJJ, Michiels JJ, Bakker JJ, van ‘t Veer MB (1994) Effectiveness of high-dose gamma globulin therapy in acquired von Willebrand’s disease. Vox Sang 67: 14–17PubMedCrossRefGoogle Scholar
  11. 11.
    Goudemand J, Samor B, Caron C, Jude B, Gosset D, Mazurier C (1988) Acquired type II von Willebrand’s disease: demonstration of a complexed inhibitor of the von Willebrand factor-platelet interaction and response to treatment. Br J Haematol 68: 227–233PubMedCrossRefGoogle Scholar
  12. 12.
    Gross S et al (1992) Efficacy of high-dose intravenous gammaglobulin in the management of acquired von Willebrand’s disease during orthopaedic surgery. Br J Haematol 82: 170–171PubMedCrossRefGoogle Scholar
  13. 13.
    Kreuz W et al (1990) Induction of von Willebrand disease type I by valproic acid. The Lancet 335: 1350–1351CrossRefGoogle Scholar
  14. 14.
    Lazarchick J, Pappas AA, Kizer J, Hall SA (1986) Acquired von Willebrand syndrome due to an inhibitor specific for von Willebrand factor antigens. Am J Hematol 21: 305–314PubMedCrossRefGoogle Scholar
  15. 15.
    Macik BG, Gabriel DA, White GC, High K, Roberts H (1988) The use of high-dose intravenous gammaglobulin in acquiered von Willebrand syndrome. Arch Pathol Lab Med 112: 143–146PubMedGoogle Scholar
  16. 16.
    Soft LE, Green D (1993) Autoantibody to von Willebrand factor in systemic lupus erythematosus. J Lab Clin Med 121: 424–430Google Scholar
  17. 17.
    White LA, Chisholm M (1993) Gastro-intestinal bleeding in acquired von Willebrand’s disease. Br J Haematol 84: 332–334PubMedCrossRefGoogle Scholar
  18. 18.
    Verstraete M (1994) Haemostatic drugs. In: Bloom AL, Forbes CD, Thomas DP, Tuddenham EGD (eds) Haemostasis and Thrombosis, third edition. Churchill Livingstone, Edinburgh London Madrid Melbourne New York Tokyo, p 1057Google Scholar

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© Springer-Verlag Berlin Heidelberg 1998

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  • E. Lechler

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