Prevalence of APC-Resistance in the East Bohemian Region

  • P. Dulíček
  • L. Chrobák
  • V. Řehaček
  • V. Šafářová
Conference paper


Venous thrombosis is a common cause of morbidity and mortality in Europeans. Recently Dahlbäck et al. [1] identified a new mechanism causing inherited thrombophilia, characterized by a poor anticoagulant response to activated protein C (APC resistance). The molecular defect underlying this phenomenon was identified as a single base change, G→A, at nucleotide 1691 of the factor V gene, causing the arginine at 506 to be replaced by glutamine [2]. The Glu506 form, called factor V Leiden is inactivated 10 to 20 times more slowly, leading to a life-long prothrombotic tendency. The increased risk is five-to tenfold for heterozygotes and 8o-fold for homozygotes [4].


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Dahlbäck B, Carlsson M, Svensson PJ (1993) Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C; prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 90: 1004–1008PubMedCrossRefGoogle Scholar
  2. 2.
    Bertina RM, Koeleman BPC, Koster T et al (1994) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369: 64–67PubMedCrossRefGoogle Scholar
  3. 3.
    Dahlbäck B (1995) Resistance to activated protein C, the Arg506 to Gln mutation in the factor V gene, and venous thrombosis. Thromb Haemost 73: 739–742PubMedGoogle Scholar
  4. 4.
    Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH (1995) High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 85: 1504–1508PubMedGoogle Scholar
  5. 5.
    Rees DC, Cox M, Clegg JB (1995) World distribution of factor V Leiden. Lancet 346: 1133–1134PubMedCrossRefGoogle Scholar
  6. 6.
    Mannucci PM, Duca F, Peyvandi F, Taghabue L, Merati G, Martinelli I, Cattaneo M (1996) Frequency of factor V Arg 506 Gln in Italians. Thromb Haemost 75: 694Google Scholar
  7. 7.
    Chaida C, Gialeraki A, Tsoukala C, Mandalaki T (1996) Prevalence of the V Q506 mutation in Hellenic population. Thromb Haemost 76: 127PubMedGoogle Scholar
  8. 8.
    Arruda VR, von Zuben PH, Soares MCP, Menezes R, Annichino-Bizzachi JH, Costa FF (1995) Very low incidence of Arg506-Gin mutation in the factor V gene among the Amazonian indians and the Brazilian black population. Thromb Haemost 73: 739–742Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • P. Dulíček
  • L. Chrobák
  • V. Řehaček
  • V. Šafářová

There are no affiliations available

Personalised recommendations