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Prevalence of APC-Resistance in the East Bohemian Region

  • P. Dulíček
  • L. Chrobák
  • V. Řehaček
  • V. Šafářová
Conference paper

Abstract

Venous thrombosis is a common cause of morbidity and mortality in Europeans. Recently Dahlbäck et al. [1] identified a new mechanism causing inherited thrombophilia, characterized by a poor anticoagulant response to activated protein C (APC resistance). The molecular defect underlying this phenomenon was identified as a single base change, G→A, at nucleotide 1691 of the factor V gene, causing the arginine at 506 to be replaced by glutamine [2]. The Glu506 form, called factor V Leiden is inactivated 10 to 20 times more slowly, leading to a life-long prothrombotic tendency. The increased risk is five-to tenfold for heterozygotes and 8o-fold for homozygotes [4].

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • P. Dulíček
  • L. Chrobák
  • V. Řehaček
  • V. Šafářová

There are no affiliations available

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