Prevalence of APC-Resistance in the East Bohemian Region
Venous thrombosis is a common cause of morbidity and mortality in Europeans. Recently Dahlbäck et al.  identified a new mechanism causing inherited thrombophilia, characterized by a poor anticoagulant response to activated protein C (APC resistance). The molecular defect underlying this phenomenon was identified as a single base change, G→A, at nucleotide 1691 of the factor V gene, causing the arginine at 506 to be replaced by glutamine . The Glu506 form, called factor V Leiden is inactivated 10 to 20 times more slowly, leading to a life-long prothrombotic tendency. The increased risk is five-to tenfold for heterozygotes and 8o-fold for homozygotes .
Unable to display preview. Download preview PDF.
- 6.Mannucci PM, Duca F, Peyvandi F, Taghabue L, Merati G, Martinelli I, Cattaneo M (1996) Frequency of factor V Arg 506 Gln in Italians. Thromb Haemost 75: 694Google Scholar
- 8.Arruda VR, von Zuben PH, Soares MCP, Menezes R, Annichino-Bizzachi JH, Costa FF (1995) Very low incidence of Arg506-Gin mutation in the factor V gene among the Amazonian indians and the Brazilian black population. Thromb Haemost 73: 739–742Google Scholar