Organization of a Randomized Clinical Trial for the Prevention of Recurrent Thrombosis in the Antiphospholipid Syndrome: the WAPS Project (Warfarin in Antiphospholipid Syndrome)

  • G. Finazzi
  • R. Marchioli
  • T. Barbui
Conference paper

Abstract

Antiphospholipid (aPL) antibodies are a heterogeneous family of immunoglobulins directed against different protein-phospholipid complexes [1, 2]. They include lupus anticoagulants (LA) and anticardiolipin antibodies (aCL). The former recognize the (human) prothrombin-phospholipid complex, thereby inhibiting the phospholipid-dependent coagulation reactions [3], whereas the latter is directed towards β2-glycoprotein I (β2-GPI) bound to an anionic lipid surface [4, 5]. aCL can be divided into two groups [6, 7]: aCL type A, which inhibit coagulation reactions by enhancing the binding of β2-GPI to the procoagulant phospholipid surface; and aCL type B, which are devoid of anticoagulant properties. In recent years, the presence of aPL which recognize lipid-bound Protein S and lipid-bound activated Protein C (aPC) has been reported [8–10]. A consistent finding of many studies is the inhibition by aPL of the inactivation of factor Va by aPC in the presence of Protein S. In this way, aPL can interfere with the physiological function of these natural anticoagulants, suggesting a possible, albeit still unproven, mechanism for their association with thrombotic events [11, 12].

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • G. Finazzi
  • R. Marchioli
  • T. Barbui

There are no affiliations available

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