Abstract
When a single radioactive bolus is placed on the carina or the main bronchus of the normal dog through a vinyl tube under bronchoscopic guidance, the radioactive bolus is transported upward toward the vocal cord with the mucous blanket or the mucus layer along the main bronchus passing the carina or along the trachea at a nearly constant steady velocity. The transport can be well appreciated by sequential or follow-up imaging as shown in Fig. 10.1. The transport velocity is calculated by dividing the migrating distance of the radioactive bolus by time required for the transport. The transport velocity of the particular dog in Fig. 10.1 was 12 mm/min.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Isawa T, Hirano T, Teshima T, Konno K (1980) Effect of non-filtered and filtered cigarette smoke on mucociliary clearance mechanism. Tohoku J Exp Med 130:189–197
Hirano T (1988) Mucociliary clearance mechanisms. II. Acute effect of cigarette smoke with and without filter and recovery from its damaging effect on tracheal mucous velocity. Kohkenshi 40:115–127
Isawa T, Teshima T, Hirano T, Ebina A, Konno K (1981) Radioaerosol inhalation lung cine-scintigraphy: a preliminary report. Tohoku J Exp Med 134:245–255
Isawa T, Teshima T, Hirano T, Ebina A, Konno K (1984) Mucociliary clearance mechanisms in smoking and nonsmoking normal subjects. J Nucl Med 25:352–359
Isawa T, Teshima T, Hirano T, Ebina A, Motomiya M, Konno K (1984) Lung clearance mechanisms in obstructive airways disease. J Nucl Med 25:447–454
Teshima T, Isawa T, Hirano T, Anazawa Y, Miki M, Motomiya M (1989) Image processing for mucociliary transport system. Respiration 8:828–835
Isawa T, Teshima T, Hirano T, Anazawa Y, Miki M, Konno K, Motomiya M (1989) Normal values for quantitative parameters for evaluation of mucociliary clearance in lungs. Tohoku J Exp Med 158:119–131
Miki M, Isawa T, Teshima T, Anazawa Y, Motomiya M (1992) Difference in inhaled aerosol deposition patterns in the lungs due to three different sized aerosols. Nucl Med Commun 13:553–562
Isawa T, Teshima T, Hirano T, Anazawa Y, Miki M, Konno, K, Motomiya M (1990) Mucociliary clearance and transport in bronchiectasis: global and regional assessment. J Nucl Med 31:543–548
Isawa T, Teshima T, Hirano T, Ebina A, Konno K (1986) Mucociliary clearance mechanisms in lung cancer. Kohkenshi 38:147–157
Isawa T, Teshima T, Hirano T, Ebina A, Konno K (1986) Mucociliary clearance mechanism in interstitial lung disease. Tohoku J Exp Med 148:169–178
Isawa T, Teshima T, Hirano T, Ebina A, Anazawa Y, Konno K (1988) Mucociliary clearance in pulmonary vascular disease. Ann Nucl Med 2:41–47
Sackner MA (1978) Effects of respiratory drugs on mucociliary clearance. Chest 73 [Suppl].-958–964
Matthys H, Koehler D (1980) Effect of theophylline on mucociliary clearance in man. Eur J Respir Dis [Suppl] 109:98–102
Wanner A (1981) Alteration of tracheal mucociliary transport in airway disease. Effect of pharmacologic agents. Chest 80 [Suppl]:967–870
Pavia D, Sutton PP, Lopez-Vidriero, MT, Agnew JE, Clarke SW (1983) Drug effects on mucociliary function. Eur J Respir Dis 64 [Suppl 1281:304–317
Isawa T, Teshima T, Hirano T, Ebina A, Konno K (1984) Evaluation of mucociliary clearance mechanisms by radioaerosol inhalation lung scintigraphy - effect of oral bromhexine. J Jpn Soc Chest Dis 22:899–909
Van As (1974) The role of selective beta 2-adrenoreceptor stimulants in the control of ciliary activity. Respiration 31:146–151
Isawa T, Teshima T, Hirano T, Ebina A, Konno K (1986) Effect of oral salbutamol on mucociliary clearance mechanisms in the lungs. Tohoku J Exp Med 150:51–61
Isawa T, Teshima T, Hirano T, Anazawa Y, Miki M, Konno K, Motomiya M (1990) Does a beta 2-stimulator really facilitate mucociliary transport in the human lungs in vivo? Am Rev Respir Dis 141:715–720
Isawa T, Teshima T, Hirano T, Ebina A, Anazawa Y, Konno K (1987) Effect of bronchodilation on the deposition and clearance of radioaerosol in bronchial asthma in remission. J Nucl Med 28:1901–1906
Rights and permissions
Copyright information
© 1998 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Isawa, T. (1998). Mucociliary Clearance. In: Nuclear Imaging of the Chest. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80387-1_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-80387-1_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80389-5
Online ISBN: 978-3-642-80387-1
eBook Packages: Springer Book Archive