Significance of Ion Channels and Membrane Potential Changes in Cells

  • Sandor Damjanovich
Part of the Springer Lab Manual book series (SLM)


Ion channels are integral membrane proteins spanning membranes. These proteins have virtual holes inside (which actually serve as tunnels) allowing ions to pass through, thereby circumventing the hydrophobic barrier of the lipid bilayer that separates cell interior from extracellular space. The cations and anions pass through their specialized channels in a strictly regulated way, in which the diameter and fixed charges in the actual ion tunnel are important, but not exclusive, restricting structural characteristics. Ion channels of cells from the nervous system and muscles are well studied and display enormous diversity (Lewis and Cahalan 1988; Pieri et al. 1989; Jan and Jan 1990).


Cystic Fibrosis Hydrate Shell Electrochemical Potential Diffusion Potential Ehrlich Ascites Tumor Cell 
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  1. Bashford CL, Pasternak CA (1986) Plasma membrane potential of some animal cells is generated by ion pumping, not by ion gradients. Trends Biochem Sci 11: 113–116CrossRefGoogle Scholar
  2. Damjanovich S, Edidin M, Szöllösi J, Trón L (1994) Mobility and proximity in biological membranes. Chapter 6. Ion channels and membrane potential changes in lymphocytes. CRC, Pearl River, NY, pp 225–326Google Scholar
  3. Grissmer S, Hanson DC, Natoli EJ, Cahalan MD, Chandy KG (1990a) CD4–CD8- T cells from mice with collagen arthritis display aberrant expression of type 1 K+ channels. J Immunol 145: 2105–2109PubMedGoogle Scholar
  4. Grissmer S, Dethlef B, Wasmoth JJ, Godlin AL, Gutman GA, Cahalan MD, Chandy KG (1990b) Expression and chromosomal localization of a lymphocyte K+ channel gene. Proc Natl Acad Sci USA 87: 9411–9415PubMedCrossRefGoogle Scholar
  5. Jan LY, Jan YN (1990) How might the diversity of potassium channels be generated? Trends Neurosci 13: 415–419PubMedCrossRefGoogle Scholar
  6. Lewis RJ, Cahalan MD (1988) Plasticity of ion channels: parallels between the nerv-ous and the immune systems. Trends Neurosci. 11: 214–218PubMedCrossRefGoogle Scholar
  7. Pieri C, Recchioni R, Moroni F, Balkay L, Marian T, Tron L, Damjanovich S. (1989) Ligand and voltage gated sodium channels may regulate electrogenic pump activity in human, mouse and rat lymphocytes. Biochem Biophys Res Comm 160: 999–1002PubMedCrossRefGoogle Scholar
  8. Rich DP, Anderson MP, Gregory RJ, Cheng SH, Paul S, Jefferson DM, McCann JD, Klinger KW, Smith AE, Welch MJ (1990) Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells. Nature 347: 358–363PubMedCrossRefGoogle Scholar
  9. Van DuijnB, Vogelzang SA (1989) The membrane potential of the cellular slime mold Dictyostelium discoideum is mainly generated by an electrogenic proton pump. Biochim Biophys Acta 983: 186–192PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1998

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  • Sandor Damjanovich

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