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Inhalationsanästhesie heute — Ein Update

  • J. Scholz
Conference paper
Part of the Refresher Course Aktuelles Wissen für Anästhesisten book series (REFRESHER COUR, volume 23)

Zusammenfassung

Am 16. Oktober 1846, also vor 150 Jahren, wurde von WTG Morton die erste Äther- Narkose durchgeführt (Abb. 1). Dieses Inhalationsanästhetikum steht uns wegen seiner Feuergefährlichkeit für die klinische Praxis heutzutage nicht mehr zur Verfügung. Auch das ein Jahr später eingeführte Chloroform wurde wegen seiner Toxizität verlassen. 1951 wurde Halothan synthetisiert und 1956 in die klinische Praxis eingeführt. Von 1959 bis 1966 haben RC Terrell und Mitarbeiter 700 Methylethyläther synthetisiert und von diesen war die 347. Substanz Enfluran, die 469. Substanz Isofluran und die 653. Substanz Desfluran. 1970 haben RF Wallin und Mitarbeiter verschiedene Isopropyläther synthetisiert, einer von ihnen war das Se- vofluran. Das heißt, die jetzt in die klinische Praxis neu eingeführten Substanzen Desfluran und Sevofluran sind eigentlich alte Inhalationsanästhetika [1, 2]. Trotz alledem wurde Sevofluran erst 1990 in Japan erstmals zugelassen und Desfluran 1992 in den USA. Seit 1995 sind Desfluran und Sevofluran auch in Deutschland zugelassen. Man fragt sich also, warum diese „alten“Substanzen erst heute in die klinische Praxis eingeführt werden.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

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  • J. Scholz

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