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Pharmacodynamics of Fluoroquinolones in Experimental Animals

  • Chapter
Quinolone Antibacterials

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 127))

Abstract

The efficacy of antimicrobials in experimental infections in animals is dependent on both the pharmacokinetics and pharmacodynamics of the drug. The pharmacokinetics of fluoroquinolones in experimental animals is reviewed in Chap. 5. This chapter reviews the pharmacodynamics of these agents in animal infection models with infections induced by extracellular and intracellular pathogens. The discussion focuses not only on the efficacy of fluoroquinolones, but also on the emergence of resistance to these drugs during therapy.

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Authors
  1. W. Craig
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  2. A. Dalhoff
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Editors and Affiliations

  1. Bayer AG Geschäftsbereich Pharma Pharma-Forschungszentrum, Institut für Klinische Pharmakologie, Geb. 429, D-42096, Wuppertal, Germany

    J. Kuhlmann

  2. Institut für Medizinische Mikrobiologie und Virologie, Christian-Albrechts-Universität, D-24105, Brunswiker Str. 4, Kiel, Germany

    A. Dalhoff

  3. Bayer AG Geschäftsbereich Pharma Pharma-Forschungszentrum, Institut für Chemotherapie, Geb. 405, D-42096, Wuppertal, Germany

    H.-J. Zeiler

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Craig, W., Dalhoff, A. (1998). Pharmacodynamics of Fluoroquinolones in Experimental Animals. In: Kuhlmann, J., Dalhoff, A., Zeiler, HJ. (eds) Quinolone Antibacterials. Handbook of Experimental Pharmacology, vol 127. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80364-2_7

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  • DOI: https://doi.org/10.1007/978-3-642-80364-2_7

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